Dr Ciaren Graham

How I’ll teach you

Haematology

Cancer Biology

Proteomics

Academic and professional qualifications

Doctor of Philosophy (PhD)

Postgraduate Certificate in Education (PGCE)

Research expertise

My research involves the use state of the art mass spectrometry to elucidate the underlying signal transduction mechanisms that lead to the development of leukaemia and myeloproliferative disorders. Myeloproliferative neoplasms (MPN) are clonal stem cell disorders that can progress to acute leukaemia. Approximately, 3,300 people are diagnosed with MPN, in the UK, every year. These neoplasms provide an attractive model for cancer development and progression as the majority of patients with MPN present at a relative early stage in the disease. There is a need for new and improved therapies in the treatment of MPNs. However, in order to design next generation drugs, it is essential that we gain a fuller understanding of the complex networks involved in MPN cell biology and disease progression. With proteomic-profiling strategies, such as SWATH-MS SILAC, pulse-SILAC and iTRAQ we will further our understanding of the regulation of MPN cell biology, which will improve our ability to design better clinical therapies to treat these diseases.

Publications

• Featured Works

  MR. Russell, C. Graham, A. D'Amato, A. Gentry-Maharaj, A. Ryan, et al. JK. Kalsi, C. Ainley, AD. Whetton, U. Menon, I. Jacobs, RLJ. Graham. (2017). A combined biomarker panel shows improved sensitivity for the early detection of ovarian cancer allowing the identification of the most aggressive type II tumours. British Journal of Cancer. 117(5), pp.666-674.

  MR. Russell, A. D’Amato, C. Graham, EJ. Crosbie, A. Gentry-Maharaj, et al. A. Ryan, JK. Kalsi, E-O. Fourkala, C. Dive, M. Walker, AD. Whetton, U. Menon, I. Jacobs, RLJ. Graham. (2017). Novel risk models for early detection and screening of ovarian cancer. Oncotarget. 8(1), pp.785-797.

  C. Graham, H. Matta, Y. Yang, H. Yi, Y. Suo, et al. B. Tolani, PM. Chaudhary. (2013). Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-κB activation. Journal of virology. 87(4), pp.2242-2252.

• Journal articles

  MR. Russell, C. Graham, A. D'Amato, A. Gentry-Maharaj, A. Ryan, et al. JK. Kalsi, C. Ainley, AD. Whetton, U. Menon, I. Jacobs, RLJ. Graham. (2017). A combined biomarker panel shows improved sensitivity for the early detection of ovarian cancer allowing the identification of the most aggressive type II tumours. British Journal of Cancer. 117(5), pp.666-674.

  MR. Russell, A. D’Amato, C. Graham, EJ. Crosbie, A. Gentry-Maharaj, et al. A. Ryan, JK. Kalsi, E-O. Fourkala, C. Dive, M. Walker, AD. Whetton, U. Menon, I. Jacobs, RLJ. Graham. (2017). Novel risk models for early detection and screening of ovarian cancer. Oncotarget. 8(1), pp.785-797.

  C. Graham, L. Brown, C. Rinadli, Y. Martyn (2014). GATA1 Is Overexpressed in Patients with Essential Thrombocythemia and It Is Normalized By Anagrelide Treatment. Blood.

  C. Graham, H. Matta, Y. Yang, H. Yi, Y. Suo, et al. B. Tolani, PM. Chaudhary. (2013). Kaposi's sarcoma-associated herpesvirus oncoprotein K13 protects against B cell receptor-induced growth arrest and apoptosis through NF-κB activation. Journal of virology. 87(4), pp.2242-2252.

  S. Jain, C. Graham, RLJ. Graham, G. McMullan, NG. Ternan (2011). Quantitative proteomic analysis of the heat stress response in Clostridium difficile strain 630. J Proteome Res. 10(9), pp.3880-3890.

  C. Graham, G. McMullan, RLJ. Graham (2011). Proteomics in the microbial sciences. Bioeng Bugs. 2(1), pp.17-30.

  C. Graham, G. McMullan, RLJ. Graham (2011). Proteomics in the microbial sciences. Bioengineered bugs. 2(1), pp.17-30.

  E. Dobbin, C. Graham, RW. Freeburn, RD. Unwin, JR. Griffiths, et al. A. Pierce, AD. Whetton, H. Wheadon. (2010). Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Res. 5(3), pp.226-243.

  E. Dobbin, C. Graham, PM. Corrigan, KG. Thomas, RW. Freeburn, et al. H. Wheadon. (2009). Tel/PDGFRbeta induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Exp Hematol. 37(1), pp.111-121.

  L. Hoey, H. McNulty, EME. McCann, KJ. McCracken, JM. Scott, et al. BB. Marc, AM. Molloy, C. Graham, K. Pentieva. (2009). Laying hens can convert high doses of folic acid added to the feed into natural folates in eggs providing a novel source of food folate. Br J Nutr. 101(2), pp.206-212.

  RLJ. Graham, C. Graham, D. Theakston, G. McMullan, C. Shaw (2008). Elucidation of trends within venom components from the snake families Elapidae and Viperidae using gel filtration chromatography. Toxicon. 51(1), pp.121-129.

  I. Hininger-Favier, M. Andriollo-Sanchez, J. Arnaud, N. Meunier, S. Bord, et al. C. Graham, A. Polito, G. Maiani, JM. O'Connor, C. Coudray, A-M. Roussel. (2007). Age- and sex-dependent effects of long-term zinc supplementation on essential trace element status and lipid metabolism in European subjects: the Zenith Study. Br J Nutr. 97(3), pp.569-578.

  C. Graham, SC. Richter, S. McClean, E. O'Kane, PR. Flatt, et al. C. Shaw. (2006). Histamine-releasing and antimicrobial peptides from the skin secretions of the dusky gopher frog, Rana sevosa. Peptides. 27(6), pp.1313-1319.

  RLJ. Graham, C. Graham, S. McClean, T. Chen, M. O'Rourke, et al. D. Hirst, D. Theakston, C. Shaw. (2005). Identification and functional analysis of a novel bradykinin inhibitory peptide in the venoms of New World Crotalinae pit vipers. Biochem Biophys Res Commun. 338(3), pp.1587-1592.

  H. Zheng, PC. Ojha, S. McClean, C. Graham, ND. Black, et al. JG. Hughes, C. Shaw. (2005). A computational approach for peptidomic analysis in taxonomic study of amphibian species. IEEE Trans Nanobioscience. 4(3), pp.241-247.

  C. Graham, AE. Irvine, S. McClean, SC. Richter, PR. Flatt, et al. C. Shaw. (2005). Peptide Tyrosine Arginine, a potent immunomodulatory peptide isolated and structurally characterized from the skin secretions of the dusky gopher frog, Rana sevosa. Peptides. 26(5), pp.737-743.

Visiting and honorary positions

Research Fellow University of Manchester

Membership of professional associations

Fellow of the Higher Education Academy (FHEA)

Fellow of the Institute of Biomedical Sciences (FIBMS)

Member of the British Society of Haematology