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University of Manchester (2011-2013)- Postdoctoral Research Associate with Dr Paul Brownbill and Prof Colin Sibley (BHF Funded)
University of Leicester (2008-2011)- Postdoctoral Research Associate with Prof Martyn Mahaut-Smith and Prof Richard Evans
Imperial College London (2007-2008) - Postdoctoral Research Associate with Dr Michael Emerson (NC3Rs funded)
Unit leader:
Teaching:
Unit Leader:
Teaching:
External PhD examiner
Dr Sarah Jones has over 15 years experience researching platelet biology and the activatory and inhibitory signalling mechanisms involved in the fine tuning of platelet responses in thrombosis and haemostasis. Recent work in Dr Jones' lab has focussed on the cross-talk between platelets and endothelial cells and how the 'health' of the endothelium dictates thrombotic responses, as well as influencing the efficacy of standard antithrombotic treatments. Current studies include developing endothelialized in vitro models of thrombosis with exposed extracellular matrices and endothelial cell phenotype relevant to cardiovascular disease, or pathogen induced thromboinflammation, to facilitate the discovery of novel therapeutic interventions.
Dr Jones also has an interest in endothelial 'health' in the placental circulation and how this impacts on fetal growth and development. Previous work has demonstrated endothelial dysfunction in placenetal vessels in pregnancies complicated by fetal growth restriction (FGR), with aboloished flow mediated vasodilatation. Current work is focussued on investigating whether vascular changes in FGR promote a pro-thrombotic environment potentially leading to placental thromboses and a poor outcome.
Manchester Metropolitan University
University of Manchester
Central Manchester Foundation Trust
University of Cambridge
Maastrict University
JR. Wright, S. Jones, S. Parvathy, LK. Kaczmarek, I. Forsythe, et al. RW. Farndale, JM. Gibbins, MP. Mahaut-Smith. (2022). The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen. Platelets. 33(3), pp.451-461.
A. Brook, A. Hoaksey, R. Gurung, EEC. Yoong, R. Sneyd, et al. GC. Baynes, H. Bischof, S. Jones, LE. Higgins, C. Jones, SL. Greenwood, RL. Jones, M. Gram, I. Lang, G. Desoye, J. Myers, H. Schneider, SR. Hansson, IP. Crocker, P. Brownbill. (2019). Correction. FASEB J. 33(5), pp.6682-6682.
S. Jones, H. Bischof, I. Lang, G. Desoye, SL. Greenwood, et al. ED. Johnstone, M. Wareing, CP. Sibley, P. Brownbill. (2015). Dysregulated flow-mediated vasodilatation in the human placenta in fetal growth restriction. The Journal of Physiology. 593(14), pp.3077-3092.
S. Jones, RJ. Evans, MP. Mahaut-Smith (2014). Ca2+ influx through P2X1 receptors amplifies P2Y1 receptor-evoked Ca2+ signaling and ADP-evoked platelet aggregation. Mol Pharmacol. 86(3), pp.243-251.
K. Lattey, H. Bischof, C. Haywood, P. Brownbill, S. Jones (2014). 167 TRPV4; a Potential New Target to Increase Placental Blood Flow in Fetal Growth Restricted Pregnancies?. Heart. 100 Suppl 3(Suppl 3), pp.A95-A96.
K. Lattey, H. Bischof, C. Hayward, P. Brownbill, S. Jones (2014). The Potential Role of Calcium Channels P2X4 and TRPV4 as Shear Stress Sensors in the Fetoplacental Endothelium. REPRODUCTIVE SCIENCES. 21(3), pp.91A-91A.
MH. Abumaree, P. Brownbill, G. Burton, C. Castillo, L. Chamley, et al. BA. Croy, S. Drewlo, C. Dunk, S. Girard, S. Hansson, S. Jones, A. Jurisicova, R. Lewis, M. Letarte, M. Parast, C. Pehrson, D. Rappolee, H. Schneider, D. Tannetta, S. Varmuza, C. Wadsack, AE. Wallace, C. Zenerino, GE. Lash. (2014). IFPA Meeting 2013 Workshop Report III: Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta. Placenta. 35(SUPPL),
MH. Abumaree, P. Brownbill, G. Burton, C. Castillo, L. Chamley, et al. BA. Croy, S. Drewlo, C. Dunk, S. Girard, S. Hansson, S. Jones, A. Jurisicova, R. Lewis, M. Letarte, M. Parast, C. Pehrson, D. Rapolee, H. Schneider, D. Tannetta, S. Varmuza, C. Wadsack, AE. Wallace, C. Zeniro, GE. Lash. (2013). IFPA Meeting 2013 Workshop Report III: Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta. Placenta.
U. Lalo, S. Jones, JA. Roberts, MP. Mahaut-Smith, RJ. Evans (2012). Heat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness. Journal of Biological Chemistry. 287(39), pp.32747-32754.
S. Vaiyapuri, CI. Jones, P. Sasikumar, LA. Moraes, SJ. Munger, et al. JR. Wright, MS. Ali, T. Sage, WJ. Kaiser, KL. Tucker, CJ. Stain, AP. Bye, S. Jones, E. Oviedo-Orta, AM. Simon, MP. Mahaut-Smith, JM. Gibbins. (2012). Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation. 125(20), pp.2479-2491.
CYE. Fung, S. Jones, A. Ntrakwah, KM. Naseem, RW. Farndale, et al. MP. Mahaut-Smith. (2012). Platelet Ca(2+) responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: roles for secondary activation of P2X1 receptors and release from intracellular Ca(2+) stores. Blood. 119(15), pp.3613-3621.
S. Jones, C. Moore, M. Emerson, C. Leon, C. Gachet, et al. R. Evans, M. Mahaut-Smith. (2011). Crosstalk between P2X1 and P2Y1 receptors stimulates synergistic calcium responses and promotes adp-mediated platelet aggregation. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 9, pp.317-318.
S. Jones, A. Solomon, D. Sanz-Rosa, C. Moore, L. Holbrook, et al. EJ. Cartwright, L. Neyses, M. Emerson. (2010). The plasma membrane calcium ATPase modulates calcium homeostasis, intracellular signaling events and function in platelets. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 8(12), pp.2766-2774.
A. Solomon, S. Jones, D. Sanz-Rosa, L-M. Holbrook, C. Moore, et al. L. Neyses, M. Emerson. (2010). The Plasma Membrane Calcium ATPase Regulates Calcium Homeostasis, Function and Negative Signalling Events in Platelets. CIRCULATION. 122(21),
S. Jones, RJ. Evans, MP. Mahaut-Smith (2010). Enhancement of ADP-evoked platelet aggregation at low extracellular Ca2+ concentrations results from reduced ectonucleotidase activity. PURINERGIC SIGNALLING. 6(1), pp.131-132.
C. Tymvios, C. Moore, S. Jones, A. Solomon, D. Sanz-Rosa, et al. M. Emerson. (2009). Platelet aggregation responses are critically regulated in vivo by endogenous nitric oxide but not by endothelial nitric oxide synthase. Br J Pharmacol. 158(7), pp.1735-1742.
KL. Tucker, T. Sage, JM. Stevens, PA. Jordan, S. Jones, et al. NE. Barrett, R. St-Arnaud, J. Frampton, S. Dedhar, JM. Gibbins. (2008). A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion. Blood. 112(12), pp.4523-4531.
NE. Barrett, L. Holbrook, S. Jones, WJ. Kaiser, LA. Moraes, et al. R. Rana, T. Sage, RG. Stanley, KL. Tucker, B. Wright, JM. Gibbins. (2008). Future innovations in anti-platelet therapies. Br J Pharmacol. 154(5), pp.918-939.
S. Jones, JM. Gibbins (2008). The neurokinin 1 receptor: a potential new target for anti-platelet therapy?. Curr Opin Pharmacol. 8(2), pp.114-119.
C. Tymvios, S. Jones, C. Moore, SC. Pitchford, CP. Page, et al. M. Emerson. (2008). Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse. Thromb Haemost. 99(2), pp.435-440.
S. Jones, KL. Tucker, T. Sage, WJ. Kaiser, NE. Barrett, et al. PJ. Lowry, A. Zimmer, SP. Hunt, M. Emerson, JM. Gibbins. (2008). Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation. Blood. 111(2), pp.605-612.
S. Jones (2015). Measurement of Intracellular Ca2+ in Human Endothelial Cells. In: Handbook of Vascular Biology Techniques. Springer Netherlands, pp.95-106.
E. Stratta, V. Palin, C. Sibley, P. Brownbill, H. Bischof, et al. S. Jones, R. Jones. (2014). Glucocorticoids inhibit angiogenesis and dysregulate angiogenic factors in the human placenta. In: Placenta. Paris, FRANCE, 9/9/2014. pp.A16-A16.
S. Jones, H. Bischof, E. Johnstone, I. Lang, G. Desoye, et al. S. Greenwood, M. Wareing, C. Sibley, P. Brownbill. (2013). ELEVATED SHEAR STRESS IN FETAL GROWTH RESTRICTION RESULTS IN A SUSTAINED INCREASE IN ENDOTHELIAL EXPRESSION AND ACTIVATION OF ENOS AND INOS IN THE FETOPLACENTAL VASCULATURE. In: PLACENTA. Whistler, CANADA, 11/9/2013. pp.A64-A64.
S. Jones, H. Bischof, E. Johnstone, S. Greenwood, M. Wareing, et al. C. Sibley, P. Brownbill. (2013). FETAL INFLOW HYDROSTATIC PRESSURE MEASUREMENTS IN THE EX-VIVO PERFUSED PLACENTA CORRELATE WITH UMBILICAL ARTERY DOPPLER RI AND PI VALUES. In: PLACENTA. Whistler, CANADA, 11/9/2013. pp.A64-A64.
S. Jones, H. Bischof, E. Johnstone, S. Greenwood, M. Wareing, et al. C. Sibley, P. Brownbill. (2013). ENDOTHELIAL DYSFUNCTION OF THE FETOPLACENTAL CIRCULATION CONTRIBUTES TO THE INCREASED VASCULAR RESISTANCE OBSERVED IN FETAL GROWTH RESTRICTION. In: PLACENTA. Whistler, CANADA, 11/9/2013. pp.A22-A22.
S. Jones, WJ. Kaiser, KL. Tucker, T. Sage, NE. Barrett, et al. PJ. Lowry, A. Zimmer, SP. Hunt, M. Emerson, JM. Gibbins. (2008). A Role for Peripheral Tachykinins and the Neurokinin 1 Receptor in the Regulation of Platelet Thrombus Formation. In: PROCEEDINGS OF THE 25TH CONFERENCE OF THE EUROPEAN SOCIETY FOR MICROCIRCULATION. Budapest, HUNGARY, 26/8/2008. pp.43-46.
KL. Tucker, JM. Stevens, PA. Jordan, T. Sage, S. Jones, et al. NE. Barrett, R. St-Arnaud, J. Frampton, S. Dedhar, JM. Gibbins. (2007). Integrin Linked Kinase Is Important in Platelet Signalling and Function. In: Blood. Atlanta, GA, 8/12/2007. pp.420-420.
S. Jones, G. Graham, JM. Gibbins (2005). The role of peripheral tachykinins in platelet function. In: HEART. Univ Leicester, Leicester, ENGLAND, 21/4/2005.
Review manuscripts for Journal of Thrombosis and Haemostasis, Hypertension, Platelets, Scientific Reports, British Journal of Pharmacology, Placenta
Review Grants for BHF, MRC and BBSRC
British Heart Foundation (BHF); SIRT1: A novel antithrombotic target in cardiovascular disease? PI S.Jones, Co-I A. Unsworth. £116,967; 2021-2024
NC3Rs/BHF joint PhD Studentship; Development and characterization of a novel endothelialized in vitro model of human atherothrombosis. PI S Jones, Co-I S White. £90,000; 2019-2022