PhD Physiology, University of Manchester 2008
BSc(hons) Biomedical Sciences, University of Manchester, 2004
MT. Collins, G. Marcucci, H-J. Anders, G. Beltrami, JA. Cauley, et al. PR. Ebeling, R. Kumar, A. Linglart, L. Sangiorgi, DA. Towler, R. Weston, MP. Whyte, ML. Brandi, B. Clarke, RV. Thakker. (2023). Author Correction: Skeletal and extraskeletal disorders of biomineralization. Nat Rev Endocrinol. 19(1), pp.62-62.
MT. Collins, G. Marcucci, H-J. Anders, G. Beltrami, JA. Cauley, et al. PR. Ebeling, R. Kumar, A. Linglart, L. Sangiorgi, DA. Towler, R. Weston, MP. Whyte, ML. Brandi, B. Clarke, RV. Thakker. (2022). Skeletal and extraskeletal disorders of biomineralization. Nat Rev Endocrinol. 18(8), pp.473-489.
F. Bartoli-Leonard, FL. Wilkinson, A. Schiro, FS. Inglott, MY. Alexander, et al. R. Weston. (2019). Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling. Scientific Reports. 9(1),
D. Liu, Y. Zeinolabediny, F. Caccuri, G. Ferris, WH. Fang, et al. R. Weston, J. Krupinski, L. Colombo, M. Salmona, R. Corpas, S. Sarroca, C. Sanfeliu, A. Caruso, B. Guo, X. Zeng, M. Slevin. (2019). p17 from HIV induces brain endothelial cell angiogenesis through EGFR-1-mediated cell signalling activation. Laboratory Investigation. 99(2), pp.180-190.
F. Bartoli-Leonard, FL. Wilkinson, AWW. Langford-Smith, MY. Alexander, R. Weston (2018). The Interplay of SIRT1 and Wnt Signaling in Vascular Calcification. Frontiers in Cardiovascular Medicine. 5,
Y. Zeinolabediny, F. Caccuri, L. Colombo, F. Morelli, M. Romeo, et al. A. Rossi, S. Schiarea, C. Ciaramelli, C. Airoldi, R. Weston, L. Donghui, J. Krupinski, R. Corpas, E. García-Lara, S. Sarroca, C. Sanfeliu, M. Slevin, A. Caruso, M. Salmona, L. Diomede. (2017). HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders. Scientific Reports. 7(1),
AM. Buga, O. Ciobanu, GM. Badescu, C. Bogdan, R. Weston, et al. M. Slevin, M. Di Napoli, A. Popa-Wagner. (2016). Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients. Oncotarget. 7(14), pp.17415-17430.
A. Schiro, FL. Wilkinson, R. Weston, JV. Smyth, F. Serracino-Inglott, et al. MY. Alexander. (2015). Elevated levels of endothelial-derived microparticles, and serum CXCL9 and SCGF-β are associated with unstable asymptomatic carotid plaques. Scientific Reports. 5,
H. Khambalia, Y. Alexander, M. Nirmalan, R. Weston, P. Pemberton, et al. Z. Moinuddin, D. Van Dellen, T. Augustine. (2015). THE CLINICAL UTILITY OF INFLAMMATORY AND DIABETES MARKERS POST- SIMULTANEOUS PANCREAS AND KIDNEY TRANSPLANTATION. TRANSPLANT INTERNATIONAL. 28, pp.622-622.
R. Weston, GP. Sidgwick, N. Ahmed, N. Nazhad, A. Schiro, et al. FL. Wilkinson, MY. Alexander. (2015). Glycation and vascular calcification: developing an anti-calcification strategy. Heart. 101, pp.A14-A14.
M. Slevin, S. Matou, Y. Zeinolabediny, R. Corpas, R. Weston, et al. D. Liu, E. Boras, M. Di Napoli, E. Petcu, S. Sarroca, A. Popa-Wagner, S. Love, MA. Font, LA. Potempa, R. Al-Baradie, C. Sanfeliu, S. Revilla, L. Badimon, J. Krupinski. (2015). Monomeric C-reactive protein - A key molecule driving development of Alzheimer's disease associated with brain ischaemia?. Scientific Reports. 5,
A. Schiro, F. Wilkinson, R. Weston, J. Smyth, AJ. Boulton, et al. F. Serracino-Inglott, YM. Alexander. (2014). 179 The Role Of Microparticles in Carotid Disease. Heart. 100(Suppl 3), pp.A101.1-A101.
R. Sharifi, R. Morra, C. Denise Appel, M. Tallis, B. Chioza, et al. G. Jankevicius, MA. Simpson, I. Matic, E. Ozkan, B. Golia, MJ. Schellenberg, R. Weston, JG. Williams, MN. Rossi, H. Galehdari, J. Krahn, A. Wan, RC. Trembath, AH. Crosby, D. Ahel, R. Hay, AG. Ladurner, G. Timinszky, R. Scott Williams, I. Ahel. (2013). Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. EMBO Journal. 32(9), pp.1225-1237.
R. Weston, H. Peeters, D. Ahel (2012). ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response. Genes Dev. 26(14), pp.1558-1572.
D. Slade, MS. Dunstan, E. Barkauskaite, R. Weston, P. Lafite, et al. N. Dixon, M. Ahel, D. Leys, I. Ahel. (2011). The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase. Nature. 477(7366), pp.616-620.
PV. Mehrotra, D. Ahel, DP. Ryan, R. Weston, N. Wiechens, et al. R. Kraehenbuehl, T. Owen-Hughes, I. Ahel. (2011). DNA repair factor APLF is a histone chaperone. Mol Cell. 41(1), pp.46-55.
F. Bartoli-Leonard, Y. Alexander, R. Weston (2019). BS59 Loss of SIRT1 in diabetes enhances dna damage and reduces MRN complex activation resulting in increased vascular calcification. In: Basic Science. Manchester, ENGLAND, 3/6/2019. pp.A177-A178.
F. Bartoli-Leonard, FL. Wilkinson, Y. Alexander, R. Weston (2019). SIRT1 Deacetylation of p53 Inhibits Hyperglycaemic Induced Senescence in Vascular Smooth Muscle Cells. In: JOURNAL OF VASCULAR RESEARCH. Maastricht, NETHERLANDS, 15/4/2019. pp.11-11.
N. Edwards, AWW. Langford-Smith, M. Floren, A. Hasan, R. Weston, et al. ST. Rashid, A. Boulton, F. Bowling, W. Tan, FL. Wilkinson, MY. Alexander. (2019). Mitochondrial Hyperactivity, Impaired Matrix Adhesion and Functional Activity in Endothelial Colony Forming Cells Isolated from Patients with Diabetic Foot Ulcers. In: CARDIOVASCULAR DRUGS AND THERAPY. pp.273-273.
AWW. Langford-Smith, M. Floren, A. Hasan, R. Weston, N. Edwards, et al. ST. Rashid, A. Boulton, F. Bowling, W. Tan, FL. Wilkinson, MY. Alexander. (2018). Altered matrix adhesion, impaired function and mitochondrial hyperactivity in endothelial colony-forming cells isolated from patients with diabetic foot ulcers. In: INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. Manchester, ENGLAND, 21/7/2018. pp.A7-A8.
AWW. Langford-Smith, M. Floren, T. Wei, A. Hasan, R. Weston, et al. N. Edwards, FL. Wilkinson, Y. Alexander, ST. Rashid, F. Bowling, A. Boulton. (2018). 108 Altered matrix adhesion, impaired function and mitochondrial hyperactivity in endothelial colony forming cells isolated from patients with diabetic foot ulcers. In: Basic Science. Manchester, ENGLAND, 4/6/2018. pp.A85-A85.
F. Bartoli-Leonard, Y. Alexander, R. Weston (2018). 121 SIRT1 attenuates hyperglycaemic induced calcification and associated senescence in vascular smooth muscle cells. In: Basic Science. Manchester, ENGLAND, 4/6/2018. pp.A92-A92.
F. Bartoli-Leonard, Y. Alexander, R. Weston (2018). P354Novel small molecule SIRT1 activators attenuate vacsular calcification in an in vitro diabetic model. In: Cardiovascular Research. Vienna, AUSTRIA, 20/4/2018. pp.S91-S91.
G. P Sidgwick, R. Weston, A. M Jones, F. L Wilkinson, Y. Alexander (2017). 183 Novel glycomimetics inhibit gly-ldl induced smooth muscle cell calcification via creb. In: Heart. Manchester, ENGLAND, 5/6/2017. pp.A126.1-A126.
G. Sidgwick, R. Weston, AM. Jones, FL. Wilkinson, Y. Alexander (2017). Glycomimetics Reduce Vascular Calcification In Vitro via Regulation of CREB Phosphorylation. In: JOURNAL OF VASCULAR RESEARCH. Geneva, SWITZERLAND, 29/5/2017. pp.24-24.
N. Payton, A. Langford-Smith, R. Weston, A. Hasan, A. Jones, et al. A. Boulton, F. Bowling, ST. Rashid, F. Wilkinson, MY. Alexander. (2017). The Therapeutic Effects of a Novel Glycomimetic on the Function of Endothelial Colony Forming Progenitor Cells Isolated From Patients With Diabetic Foot Ulcers. In: JOURNAL OF VASCULAR RESEARCH. Geneva, SWITZERLAND, 29/5/2017. pp.52-52.
R. Weston, AL. Smith, A. Hasan, A. Jones, F. Wilkinson, et al. A. Boulton, F. Bowling, T. Rashid, Y. Alexander. (2017). Targeting outgrowth endothelial progenitor cell defective function using glycomimetics for improved diabetic wound healing. In: DIABETIC MEDICINE. pp.39-39.
FL. Wilkinson, GP. Sidgwick, P. Walling, A. Shabbir, R. Weston, et al. AM. Jones, MY. Alexander. (2016). GLYCOMIMETICS: A NOVEL APPROACH TO PREVENT VASCULAR CALCIFICATION. In: HEART. Univ Leeds, Leeds, ENGLAND, 5/9/2016. pp.A11-A11.
R. Weston, A. Hasan, F. Wilkinson, A. Boulton, T. Rashid, et al. F. Bowling, MY. Alexander. (2016). INVESTIGATING THE WOUND HEALING CAPACITY OF OUTGROWTH ENDOTHELIAL CELLS FROM DIABETIC NEUROPATHY AND NEUROISCHAEMIA PATIENTS. In: HEART. Univ Leeds, Leeds, ENGLAND, 5/9/2016. pp.A5-A5.
A. Hasan, R. Weston, FL. Wilkinson, A. Boulton, T. Rashid, et al. F. Bowling, MYV. Alexander. (2016). 195 Functional Defects Identified in Outgrowth Endothelial Cells from Diabetic Patients Compared to Healthy Controls. In: Heart. Manchester, ENGLAND, 6/6/2016. pp.A132.1-A132.
GP. Sidgwick, R. Weston, N. Ahmad, N. Nazhad, A. Schiro, et al. F. Serracino Inglott, FL. Wilkinson, MY. Alexander. (2016). The plant extract momordica charantia reduces expression of vascular calcification markers in a smooth muscle cell culture model. In: Atherosclerosis. pp.e11-e11.
H. Khambalia, Y. Alexander, M. Nirmalan, R. Weston, P. Pemberton, et al. Z. Moinuddin, D. van Dellen, T. Augustine. (2015). The clinical utility of inflammatory and diabetes markers post simultaneous pancreas and kidney transplantation. In: XENOTRANSPLANTATION. Melbourne, AUSTRALIA, 15/11/2015. pp.S126-S126.
H. Khambalia, Y. Alexander, M. Nirmalan, R. Weston, P. Pemberton, et al. Z. Moinuddin, D. van Dellen, T. Augustine. (2015). THE CLINICAL UTILITY OF INFLAMMATORY AND DIABETES MARKERS POST SIMULTANEOUS PANCREAS AND KIDNEY TRANSPLANTATION. In: TRANSPLANTATION. Melbourne, AUSTRALIA, 15/11/2015. pp.S210-S210.
F. Wilkinson, R. Weston, G. Sidgwick, N. Nazhad, A. Schiro (2016). Developing an approach to prevent vascular calcification. In: BRITISH JOURNAL OF SURGERY. Bournemouth, ENGLAND, 11/11/2015. pp.23-23.
A. Schiro, F. Wilkinson, R. Weston, Y. Alexander, F. Serracino-Inglott (2016). EMPs are elevated in patients with unstable asymptomatic carotid plaques. In: BRITISH JOURNAL OF SURGERY. Bournemouth, ENGLAND, 11/11/2015. pp.8-8.
R. Weston, GP. Sidgwick, N. Ahmed, N. Nazhad, A. Schiro, et al. F. Serracino Inglott, FL. Wilkinson, MY. Alexander. (2015). 42 Glycation and vascular calcification: developing an anti-calcification strategy. In: Heart. Univ Glasgow, Glasgow, SCOTLAND, 7/9/2015. pp.A14.1-A14.
R. Weston, F. Wilkinson, Y. Liu, J. Schofield, T. Siahmansur, et al. H. Soran, Y. Alexander. (2015). 214 Glycated LDL (glyc-LDL) Promotes Osteogenic Differentiation of Vascular Smooth Muscle Cells. In: Heart. Manchester, ENGLAND, 8/6/2015. pp.A117.1-A117.
F. Wilkinson, A. Schiro, R. Weston, V. Smyth, SI. Ferdinand, et al. Y. Alexander. (2015). ENDOTHELIAL MICROPARTICLES; A NOVEL BIOMARKER OF CAROTID DISEASE?. In: JOURNAL OF VASCULAR RESEARCH. Pisa, ITALY, 3/6/2015. pp.65-66.
H. Khambalia, MY. Alexander, M. Nirmalan, R. Weston, P. Pemberton, et al. Z. Moinuddin, A. Summers, D. van Dellen, T. Augustine. (2015). The temporal evolution of inflammatory and diabetes biomarkers following simultaneous pancreas and kidney transplantation (NCT01619904). In: BRITISH JOURNAL OF SURGERY. Durham Univ, Durham, ENGLAND, 7/1/2015. pp.13-14.
FL. Wilkinson, A. Schiro, R. Weston, JV. Smyth, F. Serracino-Inglott, et al. MY. Alexander. (2014). ELEVATED ENDOTHELIAL MICROPARTICLES IN ASYMPTOMATIC PATIENTS: MARKERS OF UNSTABLE PLAQUES?. In: Heart. Univ Reading, Reading, ENGLAND, 8/9/2014. pp.A3.1-A3.