Wife, mother of two sons and 1 daughter; all three happily married.
Nana to 4 young grandsons and 2 little grandaughters.
Used to be good at golf and skiing before academia and grandchildren took over.
Enjoy nights out at the theatre.
To inspire people to see their strengths and reach their potential.
Do to others as you would have them do to you.
Every cloud has a silver lining
Stem Cells in Vascular Disease
Atherosclerosis and Vascular Calcification
Signalling Networks in Cardiovascular Disease
Endothelial Dysfunction and Repair
Several Years’ Experience in Postgraduate and Undergraduate Research Supervision and Examination
BSc Hons
PhD
2000 – 2013 Lecturer/Senior Lecturer
University of Manchester
1997 2000 Lecturer (Molecular Medicine), University of
Glasgow
1991 -1999 Research
Fellow, Dept of Genetics, University of Glasgow
Head of Cardiovascular Group
Chair of Interview Panels for PhD studentships/ Selection Panel for Clinical Training Fellowships.
Appointments Committee for Academic Positions
Medical Student Application Interview Panels
Personal tutor and mentor for many students and post-docs
Conference Young Investigator and Poster Prize Judge
Chair of Lab Users Committee
English
Rusty French
Heart disease is one of the biggest killers in the UK. Understanding how our heart and blood vessels remain healthy will help in ensuring we have a good quality of life and help us enjoy life for longer.
Health Physiology
Vascular Calcification
Endothelial Dysfunction
Smooth Muscle Cell Biology
Microparticles in Disease
External Examiner for 8 PhD thesis at King’s College London;Imperial College London; University College Cork; University of Glasgow; University of Bristol and INSERM, Paris.
Reviewer of grant applications for 11 funding bodies
Reviewer of manuscripts for 21 International high ranking Journals Invited Reviewer of abstracts submitted for International and National Societies
Judge for Young Investigator Awards at International meetings.Numerous Invited National & International Lectures
2012 - British Cardiovascular Society Press Expert
2012 - Member International Scientific Programme Organising Committee for The European Vascular Biology Organisation
2013 Conference held as a symposium within the International Union of Physiologists ASC
2011 - International Advisory Board member (on behalf of EVBO) for the Joint Meeting of the 27th European Microcirculation Society and 7th European Vascular Biology Organisation during the International Union of Physiological Societies meeting 2013
2011 - Editor 'Frontiers in Clinical and Translational Physiology' 2011 - Guest reviewer of World Journal of Cardiovascular Surgery
2011 - Member International Scientific Programme Organising Committee for The Frontiers in Cardiac and Vascular Biology 2012 Conference
2007 - Member Scientific Programme Organising Committee European Vascular Biology Organisation 2007 to present
Cellular reprogramming in vascular calcification within the context of diabetes and renal disease;
Endothelial progenitor cell differentiation and impaired vascular function with age;
Endothelial dysfunction and repair in Lupus and rheumatoid arthritis patients
Identifying biomarkers in carotid disease to prevent risk of stroke
Vascular Remodelling Plaque Stability & Atherosclerosis
University of Manchester
Professor Ian Bruce - Vascular dysfunction in Rheumatoid Arthritis and Lupus
Professor Tony Heagerty - Vascular Function in Obesity and Diabetes
Professor Andrew Boulton - Diabetic Wound Healing
University of Aukland
Professor Margaret Brimble
MY. Alexander, B. Bussolati, A. Banfi (2019). Pioneering updates in vascular biology. Vascul Pharmacol. 112, pp.1-1.
HA. Khambalia, MY. Alexander, M. Nirmalan, R. Weston, P. Pemberton, et al. Z. Moinuddin, A. Summers, D. van Dellen, T. Augustine. (2018). Links between a biomarker profile, cold ischaemic time and clinical outcome following simultaneous pancreas and kidney transplantation. Cytokine. 105, pp.8-16.
EM. McCarthy, D. Moreno-Martinez, FL. Wilkinson, NJ. McHugh, IN. Bruce, et al. JD. Pauling, Y. Alexander, B. Parker. (2017). Microparticle subpopulations are potential markers of disease progression and vascular dysfunction across a spectrum of connective tissue disease. BBA Clinical. 7, pp.16-22.
S. Skeoch, PLH. Cristinacce, H. Williams, P. Pemberton, D. Xu, et al. J. Sun, J. James, C. Yuan, T. Hatsukami, PD. Hockings, MY. Alexander, JC. Waterton, IN. Bruce. (2017). Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation. Scientific reports. 7,
J. Dulak, MY. Alexander, AM. Randi (2016). Vascular biology: New mechanisms and pathways. Vascular Pharmacology. 86, pp.1-2.
AM. Mahmoud, F. Wilkinson, JA. Wilkinson, M. Romero, J. Duarte, et al. Y. Alexander, AM. Jones. (2016). A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: involvement of Akt/eNOS and Nrf2/ARE signaling. Biochimica et Biophysica Acta (BBA) - General Subjects. 1861(1), pp.3311-3322.
S. Skeoch, H. Williams, P. Cristinacce, P. Hockings, J. James, et al. Y. Alexander, J. Waterton, I. Bruce. (2015). Evaluation of carotid plaque inflammation in patients with active rheumatoid arthritis using (18)F-fluorodeoxyglucose PET-CT and MRI: a pilot study. Lancet. 385 Suppl 1, pp.S91-S91.
J. Reynolds, D. Ray, MY. Alexander, I. Bruce (2015). Role of vitamin D in endothelial function and endothelial repair in clinically stable systemic lupus erythematosus. Lancet. 385 Suppl 1, pp.S83-S83.
B. Parker, A. Al-Husain, P. Pemberton, AP. Yates, P. Ho, et al. R. Gorodkin, LS. Teh, MY. Alexander, IN. Bruce. (2014). Suppression of inflammation reduces endothelial microparticles in active systemic lupus erythematosus. ANNALS OF THE RHEUMATIC DISEASES. 73(6), pp.1144-1150.
A. Schiro, F. Wilkinson, R. Weston, J. Smyth, AJ. Boulton, et al. F. Serracino-Inglott, YM. Alexander. (2014). 179 The Role Of Microparticles in Carotid Disease. Heart. 100(Suppl 3), pp.A101.1-A101.
JA. Reynolds, AC. Robertson, IN. Bruce, MY. Alexander (2014). Improving cardiovascular outcomes in rheumatic diseases: therapeutic potential of circulating endothelial progenitor cells. Pharmacol Ther. 142(2), pp.231-243.
JA. Reynolds, DW. Ray, LAH. Zeef, T. O'Neill, IN. Bruce, et al. MY. Alexander. (2014). The effect of type 1 IFN on human aortic endothelial cell function in vitro: relevance to systemic lupus erythematosus. J Interferon Cytokine Res. 34(5), pp.404-412.
M. Slevin, M. Baldellou, E. Hill, Y. Alexander, G. McDowell, et al. C. Murgatroyd, M. Carroll, H. Degens, J. Krupinski, N. Rovira, M. Chowdhury, F. Serracino-Inglott, L. Badimon. (2014). Novel methods for accurate identification, isolation, and genomic analysis of symptomatic microenvironments in atherosclerotic arteries. Methods Mol Biol. 1135, pp.289-305.
SK. Heathfield, B. Parker, LAH. Zeef, IN. Bruce, MY. Alexander (2013). Certolizumab pegol attenuates the pro-inflammatory state in endothelial cells in a manner that is atheroprotective. Clinical and Experimental Rheumatology. 31(2), pp.0225-0233.
B. Parker, A. Al-Husain, MY. Alexander, I. Bruce (2013). SUPPRESSION OF INFLAMMATION REDUCES ENDOTHELIAL MICROPARTICLES IN ACTIVE SYSTEMIC LUPUS ERYTHEMATOSUS. RHEUMATOLOGY. 52, pp.126-126.
KA. Williamson, A. Hamilton, JA. Reynolds, P. Sipos, I. Crocker, et al. SE. Stringer, YM. Alexander. (2013). Age-related impairment of endothelial progenitor cell migration correlates with structural alterations of heparan sulfate proteoglycans. Aging Cell. 12(1), pp.139-147.
PL. Tomson, PJ. Lumley, MY. Alexander, AJ. Smith, PR. Cooper (2013). Hepatocyte growth factor is sequestered in dentine matrix and promotes regeneration-associated events in dental pulp cells. Cytokine. 61(2), pp.622-629.
SK. Heathfield, B. Parker, LAH. Zeef, IN. Bruce, MY. Alexander (2013). Certolizumab pegol attenuates the pro-inflammatory state in endothelial cells in a manner that is atheroprotective. Clin Exp Rheumatol. 31(2), pp.225-233.
B. Parker, A. Al-Husain, P. Pemberton, AP. Yates, P. Ho, et al. R. Gorodkin, LS. Teh, MY. Alexander, IN. Bruce. (2013). Suppression of inflammation reduces endothelial microparticles in active systemic lupus erythematosus. Annals of the Rheumatic Diseases.
Y. Liu, T. Wang, J. Yan, N. Jiagbogu, DAM. Heideman, et al. AE. Canfield, MY. Alexander. (2011). HGF/c-Met signalling promotes Notch3 activation and human vascular smooth muscle cell osteogenic differentiation in vitro. Atherosclerosis. 219(2), pp.440-447.
K. Williamson, SE. Stringer, P. Sipos, I. Crocker, MY. Alexander (2011). 40 Age-related modification of heparan sulphate proteoglycans on human endothelial progenitor cells. Heart. 97(20), pp.e7-e7.
SK. Heathfield, I. Bruce, MY. Alexander (2011). 10 Certolizumab pegol inhibits tumour necrosis factor-induced endothelial cell activation. Heart. 97(20), pp.e7-e7.
B. Parker, A. Zaki, S. Haque, IN. Bruce, MY. Alexander (2011). 31 Endothelial microparticles and endothelial function in active systemic lupus erythematosus (SLE): biomarkers of vascular injury?. Heart. 97(20), pp.e7-e7.
JA. Reynolds, K. Williamson, T. O'Neill, DW. Ray, IN. Bruce, et al. MY. Alexander. (2011). 36 Type 1 interferon and endothelial progenitor cell function: development of an in vitro endothelial model of systemic lupus erythematosus. Heart. 97(20), pp.e7-e7.
J. Yan, SE. Stringer, A. Hamilton, V. Charlton-Menys, C. Götting, et al. B. Müller, D. Aeschlimann, MY. Alexander. (2011). Decorin GAG synthesis and TGF-β signaling mediate Ox-LDL-induced mineralization of human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 31(3), pp.608-615.
PL. Tomson, PJ. Lumley, J. Yan, MY. Alexander, AJ. Smith, et al. PR. Cooper. (2011). Pulp capping agents release hepatocyte growth factor from dentine which may contribute to mineralised tissue repair in the dentine-pulp complex. European Cells and Materials. 22(SUPPL.2),
M. Chowdhury, J. Ghosh, M. Slevin, JV. Smyth, MY. Alexander, et al. F. Serracino-Inglott. (2010). A comparative study of carotid atherosclerotic plaque microvessel density and angiogenic growth factor expression in symptomatic versus asymptomatic patients. Eur J Vasc Endovasc Surg. 39(4), pp.388-395.
MY. Alexander (2009). RANKL links arterial calcification with osteolysis. Circ Res. 104(9), pp.1032-1034.
MY. Alexander (2009). Editorial: RANKL links arterial calcification with osteolysis. Circulation Research. 104(9), pp.1032-1034.
M-U. Alam, JP. Kirton, FL. Wilkinson, E. Towers, S. Sinha, et al. M. Rouhi, TN. Vizard, AP. Sage, D. Martin, DT. Ward, MY. Alexander, D. Riccardi, AE. Canfield. (2009). Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells. Cardiovasc Res. 81(2), pp.260-268.
B. Guinn, G. Casey, S. Collins, T. O'Brien, MY. Alexander, et al. M. Tangney. (2008). Tripartite meeting in gene and cell therapy, 2008: Irish Society for Gene and Cell Therapy, British Society for Gene Therapy, and International Society for Cell and Gene Therapy of Cancer. Hum Gene Ther. 19(10), pp.967-978.
Y. Liu, FL. Wilkinson, JP. Kirton, M. Jeziorska, H. Iizasa, et al. Y. Sai, E. Nakashima, AM. Heagerty, AE. Canfield, MY. Alexander. (2007). Hepatocyte growth factor and c-Met expression in pericytes: implications for atherosclerotic plaque development. J Pathol. 212(1), pp.12-19.
GDM. Collett, AP. Sage, JP. Kirton, MY. Alexander, AP. Gilmore, et al. AE. Canfield. (2007). Axl/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells. Circ Res. 100(4), pp.502-509.
FL. Wilkinson, Y. Liu, AK. Rucka, M. Jeziorska, JA. Hoyland, et al. AM. Heagerty, AE. Canfield, MY. Alexander. (2007). Contribution of VCAF-positive cells to neovascularization and calcification in atherosclerotic plaque development. J Pathol. 211(3), pp.362-369.
T. Daniel, M. Alexander, WJ. Hubbard, IH. Chaudry, MA. Choudhry, et al. MG. Schwacha. (2006). Nitric oxide contributes to the development of a post-injury Th2 T-cell phenotype and immune dysfunction. J Cell Physiol. 208(2), pp.418-427.
JP. Kirton, FL. Wilkinson, AE. Canfield, MY. Alexander (2006). Dexamethasone downregulates calcification-inhibitor molecules and accelerates osteogenic differentiation of vascular pericytes: implications for vascular calcification. Circ Res. 98(10), pp.1264-1272.
M. Alexander, T. Daniel, IH. Chaudry, MG. Schwacha (2005). Opiate analgesics contribute to the development of post-injury immunosuppression. J Surg Res. 129(1), pp.161-168.
MY. Alexander, FL. Wilkinson, JP. Kirton, CF. Rock, GDM. Collett, et al. M. Jeziorska, JV. Smyth, AM. Heagerty, AE. Canfield. (2005). Identification and characterization of vascular calcification-associated factor, a novel gene upregulated during vascular calcification in vitro and in vivo. Arterioscler Thromb Vasc Biol. 25(9), pp.1851-1857.
M. Alexander, T. Daniel, IH. Chaudry, MG. Schwacha (2004). MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injury. J Cell Physiol. 201(1), pp.35-44.
B. Toth, M. Alexander, T. Daniel, IH. Chaudry, WJ. Hubbard, et al. MG. Schwacha. (2004). The role of gammadelta T cells in the regulation of neutrophil-mediated tissue damage after thermal injury. J Leukoc Biol. 76(3), pp.545-552.
LP. Singh, K. Green, M. Alexander, S. Bassly, ED. Crook (2004). Hexosamines and TGF-beta1 use similar signaling pathways to mediate matrix protein synthesis in mesangial cells. Am J Physiol Renal Physiol. 286(2), pp.F409-F416.
MG. Schwacha, IH. Chaudry, M. Alexander (2003). Regulation of macrophage IL-10 production postinjury via beta2 integrin signaling and the P38 MAP kinase pathway. Shock. 20(6), pp.529-535.
G. Collett, A. Wood, MY. Alexander, BC. Varnum, RP. Boot-Handford, et al. V. Ohanian, J. Ohanian, Y-W. Fridell, AE. Canfield. (2003). Receptor tyrosine kinase Axl modulates the osteogenic differentiation of pericytes. Circ Res. 92(10), pp.1123-1129.
LP. Singh, M. Alexander, K. Greene, ED. Crook (2003). Overexpression of the complementary DNA for human glutamine:fructose-6-phosphate amidotransferase in mesangial cells enhances glucose-induced fibronectin synthesis and transcription factor cyclic adenosine monophosphate-responsive element binding phosphorylation. J Investig Med. 51(1), pp.32-41.
M. Alexander, IH. Chaudry, MG. Schwacha (2002). Relationships between burn size, immunosuppression, and macrophage hyperactivity in a murine model of thermal injury. Cell Immunol. 220(1), pp.63-69.
JP. Fennell, MJ. Brosnan, AJ. Frater, CA. Hamilton, MY. Alexander, et al. SA. Nicklin, DD. Heistad, AH. Baker, AF. Dominiczak. (2002). Adenovirus-mediated overexpression of extracellular superoxide dismutase improves endothelial dysfunction in a rat model of hypertension. Gene Ther. 9(2), pp.110-117.
LP. Singh, J. Andy, V. Anyamale, K. Greene, M. Alexander, et al. ED. Crook. (2001). Hexosamine-induced fibronectin protein synthesis in mesangial cells is associated with increases in cAMP responsive element binding (CREB) phosphorylation and nuclear CREB: the involvement of protein kinases A and C. Diabetes. 50(10), pp.2355-2362.
MY. Alexander, C. Farrington, EP. Smith, MJ. Doherty, AM. Heagerty, et al. AE. Canfield. (2001). A novel gene involved in calcification, identified using subtractive hybridisation. HYPERTENSION. 38(4), pp.968-968.
MY. Alexander (2000). Chloride ions and the endothelium: their role in adrenoceptor-mediated vasoconstriction. Cardiovasc Res. 48(3), pp.365-366.
MY. Alexander, MJ. Brosnan, CA. Hamilton, JP. Fennell, EC. Beattie, et al. E. Jardine, DD. Heistad, AF. Dominiczak. (2000). Gene transfer of endothelial nitric oxide synthase but not Cu/Zn superoxide dismutase restores nitric oxide availability in the SHRSP. Cardiovasc Res. 47(3), pp.609-617.
C. Berry, MY. Alexander, MJ. Brosnan, CA. Hamilton, JJV. McMurray, et al. AF. Dominiczak. (2000). ANGIOTENSIN II STIMULATES INCREASED EXPRESSION OF P. Journal of Hypertension. 18, pp.S189-S190.
C. Berry, CA. Hamilton, MY. Alexander, MJ. Brosnan, AF. Dominiczak, et al. JJV. McMurray. (2000). Angiotensin II stimulated superoxide production in human arteries. EUROPEAN HEART JOURNAL. 21, pp.43-43.
AF. Dominiczak, DC. Negrin, JS. Clark, MJ. Brosnan, MW. McBride, et al. MY. Alexander. (2000). Genes and hypertension: from gene mapping in experimental models to vascular gene transfer strategies. Hypertension. 35(1 Pt 2), pp.164-172.
C. Berry, MY. Alexander, MJ. Brosnan, JJV. McMurray, AF. Dominiczak (2000). Increased expression of p22phox, the active subunit of NADH oxidase, in human aortic endothelial cells stimulated with angiotensin II. EUROPEAN HEART JOURNAL. 21, pp.45-45.
JP. Fennell, MY. Alexander, MJ. Brosnan, CA. Hamilton, AF. Dominiczak (1999). Adenoviral gene transfer in human veins and a model of essential hypertension. HYPERTENSION. 34(4), pp.700-700.
MY. Alexander, KA. Webster, PH. McDonald, HM. Prentice (1999). Gene transfer and models of gene therapy for the myocardium. Clin Exp Pharmacol Physiol. 26(9), pp.661-668.
MY. Alexander, MJ. Brosnan, CA. Hamilton, P. Downie, AM. Devlin, et al. F. Dowell, W. Martin, HM. Prentice, T. O'Brien, AF. Dominiczak. (1999). Gene transfer of endothelial nitric oxide synthase improves nitric oxide-dependent endothelial function in a hypertensive rat model. Cardiovasc Res. 43(3), pp.798-807.
MY. Alexander, MJ. Brosnan, CA. Hamilton, JP. Fennell, HM. Prentice, et al. T. O'Brien, AF. Dominiczak. (1999). Restoration of nitric oxide bioavailability in the SHRSP model using adenoviral-mediated gene transfer of endothelial nitric oxide synthase into an intact endothelium. HYPERTENSION. 34(2), pp.352-352.
MY. Alexander, MJ. Brosnan, P. Downie, F. Dowell, HM. Prentice, et al. B. Martin, AF. Dominiczak. (1998). Adenoviral-mediated gene transfer of endothelial nitric oxide synthase into the intact endothelium alters vascular tone. HYPERTENSION. 32(4), pp.791-791.
AJ. Smith, M. Alexander, D. Mackenzie, A. Lennon, MP. Riggio, et al. TW. MacFarlane. (1998). Microbial factors and gingival crevicular fluid aspartate aminotransferase levels. A cross-sectional study. J Clin Periodontol. 25(4), pp.334-339.
AH. Trainer, MY. Alexander (1997). Gene delivery to the epidermis. Hum Mol Genet. 6(10), pp.1761-1767.
MY. Alexander, SI. Bidichandani, FM. Cousins, CJM. Robinson, E. Duffie, et al. RJ. Akhurst. (1996). Corrigendum: Circulating human factor IX produced in keratin-promotor transgenic mice: A feasibility study for gene therapy of haemophilia B (Journal of Human Molecular Genetics (1995) 4 (993-999)). Human Molecular Genetics. 5(8),
MY. Alexander, RJ. Akhurst (1995). Liposome-medicated gene transfer and expression via the skin. Hum Mol Genet. 4(12), pp.2279-2285.
MY. Alexander, SI. Bidichandani, FM. Cousins, CJ. Robinson, E. Duffie, et al. RJ. Akhurst. (1995). Circulating human factor IX produced in keratin-promoter transgenic mice: a feasibility study for gene therapy of haemophilia B. Hum Mol Genet. 4(6), pp.993-999.
SI. BIDICHANDANI, MY. ALEXANDER, RA. AKHURST (1995). KERATINOCYTE-SPECIFIC EXPRESSION OF FACTOR-IX FOR GENE-THERAPY FOR HEMOPHILIA-B. JOURNAL OF CELLULAR BIOCHEMISTRY. pp.374-374.
MY. ALEXANDER, SI. BIDICHANDANI, CJM. ROBINSON, RJ. AKHURST (1994). TREATMENT OF HEMOPHILIA-B BY SOMATIC-CELL GENE-THERAPY USING KERATINOCYTES AS A GENE DELIVERY SYSTEM. JOURNAL OF CELLULAR BIOCHEMISTRY. pp.241-241.
MY. Alexander, S. Bidichandani, C. Robinson, AH. Trainer, RJ. Akhurst (1994). Physical methods of gene delivery using keratinocytes as a target for somatic cell gene therapy. Gene Ther. 1 Suppl 1,
MY. ALEXANDER, CJM. ROBINSON, AH. TRAINER, RJ. AKHURST (1993). THE USE OF KERATINOCYTES FOR THE PHENOTYPIC CORRECTION OF METABOLIC DEFECTS BY SYSTEMIC DELIVERY OF THE DEFECTIVE PROTEIN. JOURNAL OF CELLULAR BIOCHEMISTRY. pp.224-224.
GP. Sidgwick, R. Weston, N. Ahmad, N. Nazhad, A. Schiro, et al. F. Serracino Inglott, FL. Wilkinson, MY. Alexander. (2016). The plant extract momordica charantia reduces expression of vascular calcification markers in a smooth muscle cell culture model. In: Atherosclerosis. pp.e11-e11.
F. Wilkinson, R. Weston, G. Sidgwick, N. Nazhad, A. Schiro (2016). Developing an approach to prevent vascular calcification. In: BRITISH JOURNAL OF SURGERY. Bournemouth, ENGLAND, 11/11/2015. pp.23-23.
A. Schiro, F. Wilkinson, R. Weston, Y. Alexander, F. Serracino-Inglott (2016). EMPs are elevated in patients with unstable asymptomatic carotid plaques. In: BRITISH JOURNAL OF SURGERY. Bournemouth, ENGLAND, 11/11/2015. pp.8-8.
J. Feng, T. Rajeswaran, S. He, FL. Wilkinson, F. Serracino-Inglott, et al. M. Azzawi, V. Parikh, M. Miraftab, MY. Alexander. (2015). Investigation of the composition of arterial plaques based on arterial waveforms and material properties. In: Annu Int Conf IEEE Eng Med Biol Soc. United States, 25/8/2015. pp.993-996.
AM. Mahmoud, FL. Wilkinson, D. Moreno-Martinez, R. Jiménez, J. Duarte, et al. MY. Alexander. (2015). 180 Endothelial microparticles prevent lipid-induced endothelial dysfunction through activation of AKT/ENOS signalling pathway and attenuation of oxidative stress. In: Heart. Manchester, ENGLAND, 8/6/2015. pp.A102.1-A102.
S. Skeoch, H. Williams, P. Cristinacce, P. Hockings, J. James, et al. J. Waterton, I. Bruce, Y. Alexander. (2015). Evaluation of carotid plaque inflammation in patients with active rheumatoid arthritis using (18)F-fluorodeoxyglucose PET-CT and MRI: a pilot study. In: Lancet.. pp.S91.-S91..
H. Khambalia, A. Summers, Z. Moinuddin, M. Nirmalan, Y. Alexander, et al. D. van Dellen, T. Augustine. (2014). Profiling the Systemic Inflammatory Response Following Pancreas and Kidney Transplantation. In: Transplantation. San Francisco, CA, 26/7/2014. pp.375-376.
HA. Khambalia, Z. Moinuddin, D. van Dellen, M. Nirmalan, Y. Alexander, et al. T. Augustine. (2014). The effect of cold ischaemic time on cytokine and diabetes markers in pancreas transplantation. In: BRITISH JOURNAL OF SURGERY. Univ Cambridge, Robinson Coll, Cambridge, ENGLAND, 8/1/2014. pp.15-15.
A. Schiro, D. Murray, JV. Smyth, A. Boulton, YM. Alexander, et al. FS. Inglott. (2014). Could microparticles act as potential biomarkers of plaque instability in patients with carotid disease?. In: BRITISH JOURNAL OF SURGERY. Manchester, ENGLAND, 27/11/2013. pp.10-10.
JA. Reynolds, DW. Ray, T. O'Neill, MY. Alexander, IN. Bruce (2013). Vitamin D Increases The Number and Function Of Myeloid Angiogenic Cells In Systemic Lupus Erythematosus. In: ARTHRITIS AND RHEUMATISM. San Diego, CA, 25/10/2013. pp.S275-S275.
S. Skeoch, P. Hubbard, H. Williams, D. Xu, S. Jie, et al. N. Balu, W. Zhang, J. James, T. Hatsukami, C. Yuan, MY. Alexander, P. Hockings, J. Waterton, IN. Bruce. (2013). Imaging Atherosclerotic Plaque Inflammation In RA: Methodology and Initial Findings In a Single Centre Cohort. In: ARTHRITIS AND RHEUMATISM. San Diego, CA, 25/10/2013. pp.S827-S827.
H. Khambalia, Z. Moinuddin, D. van Dellen, M. Nirmalan, Y. Alexander, et al. T. Augustine. (2013). Short Cold Ischaemic Times Improve Cytokine, Diabetic and Clinical Markers in Pancreas Transplantation. In: TRANSPLANTATION. Monterey, CA, 24/9/2013. pp.S34-S34.
B. Parker, A. Al-Husain, MY. Alexander, I. Bruce (2013). SUPPRESSION OF INFLAMMATION REDUCES ENDOTHELIAL MICROPARTICLES IN ACTIVE SYSTEMIC LUPUS ERYTHEMATOSUS. In: RHEUMATOLOGY. Birmingham, ENGLAND, 23/4/2013. pp.126-126.
JA. Reynolds, DW. Ray, T. O'Neill, Y. Alexander, I. Bruce (2013). INTERFERON-ALPHA MAY IMPAIR ENDOTHELIAL REPAIR MECHANISMS IN SYSTEMIC LUPUS ERYTHEMATOSUS. In: RHEUMATOLOGY. Birmingham, ENGLAND, 23/4/2013. pp.129-130.
JA. Reynolds, DW. Ray, T. O'Neill, MY. Alexander, IN. Bruce (2013). Interferon alpha impairs survival and function of circulating angiogenic cells in vitro: a model of failed endothelial repair in systemic lupus erythematosus. In: LANCET. London, ENGLAND, 27/2/2013. pp.91-91.
B. Parker, A. Zaki, MY. Alexander, IN. Bruce (2012). Endothelial Microparticles As a Biomarker for Endothelial Dysfunction in Active Systemic Lupus Erythematosus. In: ARTHRITIS AND RHEUMATISM. Washington, DC, 9/11/2012. pp.S270-S270.
JA. Reynolds, DW. Ray, T. O'Neill, MY. Alexander, IN. Bruce (2012). Interferon-Alpha Impairs the Survival and Function of Circulating Angiogenic Cells in Vitro: A Model of Failed Endothelial Repair in SLE. In: ARTHRITIS AND RHEUMATISM. Washington, DC, 9/11/2012. pp.S287-S287.
S. Heathfield, B. Parker, L. Zeef, I. Bruce, Y. Alexander (2012). CERTOLIZUMAB PEGOL PREVENTS PRO-INFLAMMATORY ALTERATIONS IN ENDOTHELIAL CELL FUNCTION. In: RHEUMATOLOGY. Glasgow, SCOTLAND, 1/5/2012. pp.140-140.
JA. Reynolds, DW. Ray, T. O'Neill, Y. Alexander, I. Bruce (2012). INTERFERON-MEDIATED VASCULAR DAMAGE IN SYSTEMIC LUPUS ERYTHEMATOSUS: FAILURE OF ENDOTHELIAL REPAIR RATHER THAN DIRECT ENDOTHELIAL TOXICITY?. In: RHEUMATOLOGY. Glasgow, SCOTLAND, 1/5/2012. pp.181-181.
B. Parker, A. Zaki, Y. Alexander, I. Bruce (2012). A COMPARISON OF PULSE AMPLITUDE TONOMETRY AND FLOW-MEDIATED DILATATION OF THE BRACHIAL ARTERY AS MEASURES OF ENDOTHELIAL FUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS. In: RHEUMATOLOGY. Glasgow, SCOTLAND, 1/5/2012. pp.178-178.
JA. Reynolds, DW. Ray, T. O'Neill, MY. Alexander, IN. Bruce (2011). Type-1 Interferon Does Not Directly Impair Endothelial Cell Function in Vitro: Implications for Cardiovascular Models of Systemic Lupus Erythematosus. In: ARTHRITIS AND RHEUMATISM. Chicago, IL, 4/11/2011. pp.S27-S27.
B. Parker, A. Zaki, S. Haque, Y. Alexander, IN. Bruce (2011). ENDOTHELIAL MICROPARTICLES AND ENDOTHELIAL FUNCTION IN ACTIVE SLE: MARKERS OF CARDIOVASCULAR RISK?. In: RHEUMATOLOGY. Brighton, ENGLAND, 12/4/2011. pp.109-110.
EJR. Hill, M. Chowdhury, F. Serracino-Inglott, M. Slevin, MY. Alexander (2011). Analysis of microvessels within carotid artery to determine plaque stability. In: BRITISH JOURNAL OF SURGERY. Royal Coll Surgery, Dublin, IRELAND, 5/1/2011. pp.34-34.
A. Ndip, YM. Alexander, A. Williams, EB. Jude, AJM. Boulton (2010). RANKL/OPG signalling pathway mediates medial arterial calcification in diabetic Charcot neuroarthropathy. In: DIABETOLOGIA. Stockholm, SWEDEN, 20/9/2010. pp.S55-S55.
EJR. Hill, M. Chowdhury, F. Serracino-Inglott, JV. Smyth, M. Slevin, et al. MY. Alexander. (2010). Microvessel analysis within endarterectomy specimens from symptomatic and asymptomatic patients to identify those at risk from plaque rupture. In: INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. Univ Manchester, Manchester, ENGLAND, 29/3/2010. pp.A13-A13.
K. Williamson, S. Haque, IN. Bruce, SE. Stringer, MY. Alexander (2010). A critical role of heparan sulphate proteoglycans as determinants of endothelial progenitor cell function in vascular ageing. In: INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. Univ Manchester, Manchester, ENGLAND, 29/3/2010. pp.A23-A24.
M. Chowdhury, J. Ghosh, MY. Alexander, JV. Smyth, F. Serracino-Inglott (2010). Can microvessel density and angiogenic growth factor expression distinguish differences in symptomatic versus asymptomatic carotid plaques?. In: BRITISH JOURNAL OF SURGERY. Royal Free Hosp, London, ENGLAND, 6/1/2010. pp.14-14.
K. Williamson, S. Haque, I. Bruce, S. Stringer, Y. Alexander (2009). The role of heparan sulphate proteoglycans on endothelial progenitor cells in age-related endothelial dysfunction. In: HUMAN GENE THERAPY. Hannover, GERMANY, 21/11/2009. pp.1452-1452.
M. Chowdhury, J. Ghosh, Y. Alexander, V. Smyth, F. Serracino-Inglott (2010). Microvessel morphology and phenotype may determine plaque vulnerability: significance for symptomatic versus asymptomatic patients?. In: BRITISH JOURNAL OF SURGERY. Liverpool, ENGLAND, 18/11/2009. pp.3-4.
S. Haque, C. Rakieh, MC. Jackson, MY. Alexander, IN. Bruce (2009). IMPAIRED ENDOTHELIAL PROGENITOR CELL FUNCTION AND EARLY ATHEROSCLEROSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS (SLE). In: RHEUMATOLOGY. Glasgow, SCOTLAND, 28/4/2009. pp.I15-I15.
JY. Yan, V. Menys, C. Goetting, B. Mueller, D. Aeschlimann, et al. MY. Alexander. (2009). GLYCOSAMINOGLYCAN CHAIN SYNTHESIS ON DECORIN CONTRIBUTES TO OXIDATIVE STRESS-INDUCED CALCIFICATION OF HUMAN VASCULAR SMOOTH MUSCLE CELLS. In: HEART. Oxford, ENGLAND, 2/4/2009.
Y. Liu, T. Wang, MY. Alexander (2008). Adenoviral-mediated overexpression of the hepatocyte growth factor inhibitor NK4 attenuates mineralization of cultured human vascular smooth muscle cells: Links with notch signalling?. In: HUMAN GENE THERAPY. Edinburgh, SCOTLAND, 7/4/2008. pp.398-398.
X. Liu, L. Liu, SY. Zhang, G. Huang, YM. Du, et al. MY. Alexander, M. Lei, B. Gao. (2008). Design of a biopacemaker: Generation of a functional I(f) pacemaker current using lentiviral-mediated gene delivery of hyperpolarization activated, cyclic nucleotide gated channel isoforms. In: HUMAN GENE THERAPY. Edinburgh, SCOTLAND, 7/4/2008. pp.414-414.
Y. Liu, FL. Wilkinson, AM. Heagerty, AE. Canfield, MY. Alexander (2007). A potential role for hepatocyte growth factor in pathological neovascularisation associated with atherosclerotic plaque development. In: HEART. Univ Cambridge, Queens Coll, Cambridge, ENGLAND, 21/9/2006.
FL. Wilkinson, JP. Kirton, AM. Heagerty, AE. Canfield, MY. Alexander (2005). VCAF, a novel gene associated with vascular calcified lesions. In: HYPERTENSION. Nice, FRANCE, 14/10/2005. pp.892-892.
JP. Kirton, FL. Wilkinson, AE. Canfield, MY. Alexander (2006). In vitro mineralization of pericytes is accelerated by glucocorticoid treatment. In: INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. Univ Manchester, Hulme Hall, Manchester, ENGLAND, 12/9/2005. pp.A26-A27.
GDM. Collett, AP. Sage, AP. Gilmore, MY. Alexander, AE. Canfield (2006). Downregulation of axl signalling enhances the osteogenic differentiation of vascular cells. In: INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY. Univ Manchester, Hulme Hall, Manchester, ENGLAND, 12/9/2005. pp.A53-A54.
M. Alexander, T. Daniel, IH. Chaudry, MA. Choudhry, MG. Schwacha (2006). T cells of the gammadelta T-cell receptor lineage play an important role in the postburn wound healing process. In: J Burn Care Res. England, 10/5/2005. pp.18-25.
FL. Wilkinson, JP. Kirton, AM. Heagerty, AE. Canfield, MY. Alexander (2005). Investigating the role of C15, a novel gene found in calcified arteries. In: ATHEROSCLEROSIS. Magdalen Coll, Oxford, ENGLAND, 14/4/2005. pp.S5-S6.
MY. Alexander (2003). Vascular calcification: Expression pattern of novel gene in human atherogenesis. In: JOURNAL OF HYPERTENSION. MILAN, ITALY, 13/6/2003. pp.S218-S218.
MY. Alexander, FW. Wilkinson, C. Griffin-Jones, C. Rock, LL. Demer, et al. M. Jeziorska, AM. Heagerty, AE. Canfield. (2003). A novel gene identified and involved in vascular calcification. In: HEART. GLASGOW, SCOTLAND, 28/4/2003. pp.A17-A17.
AF. Dominiczak, DC. Negrin, JS. Clark, MJ. Brosnan, MW. McBride, et al. MY. Alexander. (2000). Genes and hypertension: From gene mapping in experimental models to vascular gene transfer strategies. In: Hypertension. pp.164-172.
AF. Dominiczak, DC. Negrin, JS. Clark, MJ. Brosnan, MW. McBride, et al. MY. Alexander. (2000). Genes and Hypertension. In: Hypertension. ORLANDO, FLORIDA, 13/9/1999. pp.164-172.
2013 - Lead organiser of a Scientific Research Symposium on "Vascular Calcification" for The European Vascular Biology Organisation Annual Scientific Conference, joint with The International Union of Physiologists
2012 - Elected member of the Academic and Research Committee of the British Cardiovascular Society
2011 - Member of Scientific Programme Organising Committee on behalf of the European Society for Cardiology: 2nd Annual Meeting on Frontiers for Cardiac & Vascular Biology, London
Member of Scientific Programme Organising Committee of European Meeting for Vascular Biology & Medicine (EMVBM) Marseille
2011 - Lead Organiser of a Scientific Research Symposium on "Progenitor cells in Disease" for The British Cardiovascular Society Annual Scientific Conference, joint with The British Atherosclerosis Society and British Society for Cardiovascular Research
2008 - Local assistant organiser of British Society for Cardiovascular Research Conference, Manchester
2006 - Invited participant at the European Vascular Genomics Network: Toulouse Conference Centre Pierre Baudis:
Dec 11-14, 2006. 3rd European Vascular Genomics Network Conference
2005 - Member of Scientific Programme Organising Committee of EMVBM Bristol
British Society for Cardiovascular Research (Ex-Chair)
European Vascular Biology Organisation (Council Member & Web Secretary)
British Society for Biochemistry (Member)
British Society for Atherosclerosis (Member)
British Society for Endocrinology (Member)
Member of International Working Group of Biomarkers for Atherosclerosis
2013 - Lead organiser of a Scientific Research Symposium on "Vascular Calcification" for The European Vascular Biology Organisation Annual Scientific Conference, joint with The International Union of Physiologists
2012 - Elected member of the Academic and Research Committee of the British Cardiovascular Society
2011 - Member of Scientific Programme Organising Committee on behalf of the European Society for Cardiology: 2nd Annual Meeting on Frontiers for Cardiac & Vascular Biology, London Member of Scientific Programme Organising Committee of European Meeting for Vascular Biology & Medicine (EMVBM) Marseille
2011 - Lead Organiser of a Scientific Research Symposium on "Progenitor cells in Disease" for The British Cardiovascular Society Annual Scientific Conference, joint with The British Atherosclerosis Society and British Society for Cardiovascular Research2008 - Local assistant organiser of British Society for Cardiovascular Research Conference, Manchester 2006 - Invited participant at the European Vascular Genomics Network: Toulouse Conference Centre Pierre Baudis: Dec 11-14, 2006. 3rd European Vascular Genomics Network Conference 2005 - Member of Scientific Programme Organising Committee of EMVBM Bristol
Group Prizes
2014 MMU Student Research Showcase; Daniel Moreno PhD student. MicroParticles as disease biomarkers
2014 British Society for Rheumatology: Innovation award. S. Skeoch, P. Hubbard, H. Williams, J. James, Y.Alexander, J.Waterton, I. Bruce. Imaging arterial
inflammation in patients with rheumatoid arthritis.
2013 1st Prize Best Poster Award. John Reynolds, D Ray, IN Bruce,&
MY Alexander. Vitamin D as a Modifier of Endothelial Dysfunction and Drug Response in Patients with Systemic Lupus Erythematosus (SLE). Translational Medicine Showcase at the University of Manchester.
2012 1st Prize Best Poster Award. John Reynolds, D Ray, MY Alexander & IN Bruce.
Vitamin D as a Modifier of Endothelial Dysfunction and Drug Response in Patients with Systemic Lupus Erythematosus (SLE). Translational Medicine Showcase at the University of Manchester. Jan 2012
2011 1st Prize Young Investigator Award. A Ndip, A Williams, E Jude, A J M Boulton, M Y AlexanderRANKL/OPG signalling: a key player in medial arterial calcification in diabetic Charcot Neuroarthropathy, 47th European Association for the Study of Diabetes. Annual Meeting.2011 (2000 delegates) Diabetologia 65 (1) S42
Supervised Over 31 Postgraduate Research Students
Director of International Research which has led to 14 prize-winning contributions for Prof Alexander and her group at International and National meetings.
British Heart Foundation
Wellcome Trust
Medical Research Council
Arthritis Research UK
Hon Senior Lecturer in the University of Manchester
Frontiers in Physiology
British Society for Cardiovascular Research
British Atherosclerosis Society
European Vascular Biology Organisation
British Biochemical Society
British Society of Endocrinology