Oliver Sutcliffe graduated from the University of Liverpool with a BSc (Hons) in Chemical Sciences (1996) and subsequently obtained a PhD in synthetic organic chemistry working on “New Extended Dipolar Systems” under Drs Richard Storr and Thomas Gilchrist from the same institution. In 1999, he joined Professor Martin Bryce’s group at the University of Durham as a postdoctoral fellow investigating the application of enantiopure ferrocene ligands in asymmetric synthesis, before moving to industry and working as a medicinal chemist on the design, development and optimisation of drug molecules for a broad-range of biological targets, including cancer. He moved to the University of Strathclyde in 2006, obtained an MSc in Pharmaceutical Analysis and after a period at the European Directorate for the Quality of Medicines and Healthcare (EDQM) in Strasbourg was appointed as a lecturer in the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS). In January 2012, Dr Sutcliffe joined the staff at Manchester Metropolitan University as a Senior Lecturer in Psychopharmaceutical Chemistry.
Dr Sutcliffe is a Fellow (FRSC) of the Royal Society of Chemistry and has been awarded Chartered Chemist (CChem), Chartered Scientist (CSci) and European Chemist (EurChem) status. In addition to his academic position Dr Sutcliffe is also the Co-Director of the Manchester Centre for the Study of Legal Highs.
Dr Sutcliffe's research interests include the synthesis, characterisation and development of new lab/field methods for the detection and quantification of illicit drugs and new psychoactive/psychotropic substances (NPS, formally known as "legal highs"). Dr Sutcliffe works with a number of national and international groups investigating the biological, pharmaceutical and forensic properties of these materials. In addition his work also includes the application of simple chemical techniques in the source identification of these materials and the development of screening methods which can aid in the prevention of trafficking/supply of materials which pose a threat to human health.
Dr Sutcliffe runs an active, vibrant and multicultural research team (group website: www.sutcliffe-research.org). He is interested in supervising graduate and doctoral students in any area of his research interests. Throughout his academic career he has successfully supervised 13 doctoral students and 10 graduate students to completion. The current research team consists of 6 doctoral and 6 graduate students:
Doctoral Students (PhDs)
Graduate Students (Masters)
R. Solà, OB. Sutcliffe, CE. Banks, B. Maciá (2017). Ball mill and microwave assisted synthetic routes to Fluoxetine. Sustainable Chemistry and Pharmacy. 5, pp.14-21.
S. Casadio, JW. Lowdon, K. Betlem, JT. Ueta, CW. Foster, et al. (2017). Development of a novel flexible polymer-based biosensor platform for the thermal detection of noradrenaline in aqueous solutions. Chemical Engineering Journal. 315, pp.459-468.
PM. Geyer, MC. Hulme, JPB. Irving, PD. Thompson, RN. Ashton, et al. (2016). Guilty by dissociation—development of gas chromatography–mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 13 diphenidine-derived new psychoactive substances (NPSs). Analytical and Bioanalytical Chemistry. 408(29), pp.8467-8481.
LR. Cumba, JP. Smith, KY. Zuway, OB. Sutcliffe, DR. Do Carmo, et al. (2016). Forensic electrochemistry: Simultaneous voltammetric detection of MDMA and its fatal counterpart "dr Death" (PMA). Analytical Methods. 8(1), pp.142-152.
JP. Smith, OB. Sutcliffe, CE. Banks (2015). An overview of recent developments in the analytical detection of new psychoactive substances (NPSs). The Analyst. 140(15), pp.4932-4948.
LE. Connor, A. Delori, IB. Hutchison, N. Nic Daeid, OB. Sutcliffe, et al. (2015). The ecstasy and the agony; Compression studies of 3,4-methylenedioxymethamphetamine (MDMA). Acta Crystallographica Section B: Structural Science, Crystal Engineering and Materials. 71(1), pp.3-9.
JO. Igoli, G. Blackburn, AI. Gray, OB. Sutcliffe, DG. Watson, et al. (2015). Chromatographic and spectroscopic analysis of the components present in the phenanthridinium trypanocidal agent isometamidium. Analytical and Bioanalytical Chemistry. 407(4), pp.1171-1180.
LR. Cumba, AV. Kolliopoulos, JP. Smith, PD. Thompson, PR. Evans, et al. (2015). Forensic electrochemistry: Indirect electrochemical sensing of the components of the new psychoactive substance "synthacaine". Analyst. 140(16), pp.5536-5545.
KY. Zuway, JP. Smith, CW. Foster, N. Kapur, CE. Banks, et al. (2015). Detection and quantification of new psychoactive substances (NPSs) within the evolved "legal high" product, NRG-2, using high performance liquid chromatography-amperometric detection (HPLC-AD). Analyst. 140(18), pp.6283-6294.
F. Tan, JP. Smith, OB. Sutcliffe, CE. Banks (2015). Regal electrochemistry: Sensing of the synthetic cathinone class of new psychoactive substances (NPSs). Analytical Methods. 7(16), pp.6470-6474.
JP. Smith, JP. Metters, OIG. Khreit, OB. Sutcliffe, CE. Banks (2014). Forensic electrochemistry applied to the sensing of new psychoactive substances: Electroanalytical sensing of synthetic cathinones and analytical validation in the quantification of seized street samples. Analytical Chemistry. 86(19), pp.9985-9992.
A. Delori, P. Maclure, RM. Bhardwaj, A. Johnston, AJ. Florence, et al. (2014). Drug solid solutions-a method for tuning phase transformations. CrystEngComm. 16(26), pp.5827-5831.
MG. Apps, BW. Johnson, OB. Sutcliffe, SD. Brown, NJ. Wheate (2014). Amide coupling reaction for the synthesis of bispyridine-based ligands and their complexation to platinum as dinuclear anticancer agents. Journal of Visualized Experiments.
N. Nic Daeid, KA. Savage, D. Ramsay, C. Holland, OB. Sutcliffe (2014). Development of gas chromatography-mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 16 'legal high' cathinone derivatives. Science and Justice. 54(1), pp.22-31.
JP. Smith, JP. Metters, C. Irving, OB. Sutcliffe, CE. Banks (2014). Forensic electrochemistry: the electroanalytical sensing of synthetic cathinone-derivatives and their accompanying adulterants in "legal high" products. Analyst. 139(2), pp.389-400.
N. Satthaphut, OB. Sutcliffe, IDH. Oswald (2014). Putting the squeeze on mephedrone hydrogen sulfate. Zeitschrift fur Kristallographie. 229(2), pp.101-111.
JP. Smith, CW. Foster, JP. Metters, OB. Sutcliffe, CE. Banks (2014). Metallic Impurities in Graphene Screen-Printed Electrodes Can Influence Their Electrochemical Properties. Electroanalysis. 26(11), pp.2429-2433.
EY. Santali, D. Edwards, OB. Sutcliffe, S. Bailes, MR. Euerby, et al. (2014). A comparison of silica C and silica gel in HILIC mode: The effect of stationary phase surface area. Chromatographia. 77(13-14), pp.873-881.
OB. Sutcliffe, GG. Skellern, F. Araya, A. Cannavan, JJ. Sasanya, et al. (2014). Animal trypanosomosis: Making quality control of trypanocidal drugs possible. OIE Revue Scientifique et Technique. 33(3), pp.813-820.
JP. Smith, JP. Metters, DK. Kampouris, C. Lledo-Fernandez, OB. Sutcliffe, et al. (2013). Forensic electrochemistry: the electroanalytical sensing of Rohypnol® (flunitrazepam) using screen-printed graphite electrodes without recourse for electrode or sample pre-treatment. Analyst. 138(20), pp.6185-6191.
G. NaredoGonzalez, M. Jansen, R. Upreti, S. Semple, G. Merrifield, et al. (2013). 19F-magnetic resonance spectroscopy as a tool to quantify 11[beta]-hydroxysteroid dehydrogenase activity in vivo. Endocrine Abstracts. pp.1-1.
OIG. Khreit, MH. Grant, T. Zhang, C. Henderson, DG. Watson, et al. (2013). Elucidation of the Phase I and Phase II metabolic pathways of (±)-4'-methylmethcathinone (4-MMC) and (±)-4'-(trifluoromethyl)methcathinone (4-TFMMC) in rat liver hepatocytes using LC-MS and LC-MS². J Pharm Biomed Anal. 72, pp.177-185.
N. Nic Daeid, KA. Savage, D. Ramsay, C. Holland, OB. Sutcliffe (2013). Development of gas chromatography-mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 16 'legal high' cathinone derivatives. Science and Justice.
MN. Abualhasan, N. Batrawi, OB. Sutcliffe, AN. Zaid (2012). A validated stability-indicating HPLC method for routine analysis of an injectable lincomycin and spectinomycin formulation. Scientia Pharmaceutica. 80(4), pp.977-986.
S. Bawazeer, OB. Sutcliffe, MR. Euerby, S. Bawazeer, DG. Watson (2012). A comparison of the chromatographic properties of silica gel and silicon hydride modified silica gels. J Chromatogr A. 1263, pp.61-67.
N. NicDaéid, W. Meier-Augenstein, HF. Kemp, OB. Sutcliffe (2012). Using isotopic fractionation to link precursor to product in the synthesis of (±)-mephedrone: a new tool for combating "legal high" drugs. Anal Chem. 84(20), pp.8691-8696.
SD. Brown, KD. Trotter, OB. Sutcliffe, JA. Plumb, B. Waddell, et al. (2012). Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, binding kinetics and cytotoxicity. Dalton Trans. 41(37), pp.11330-11339.
MN. Abualhasan, JAD. Good, K. Wittayanarakul, NG. Anthony, G. Berretta, et al. (2012). Doing the methylene shuffle – Further insights into the inhibition of mitotic kinesin Eg5 with S-trityl l-cysteine. European Journal of Medicinal Chemistry. 54, pp.483-498.
OIG. Khreit, C. Irving, E. Schmidt, JA. Parkinson, N. Nic Daeid, et al. (2012). Synthesis, full chemical characterisation and development of validated methods for the quantification of the components found in the evolved “legal high” NRG-2. Journal of Pharmaceutical and Biomedical Analysis. 61, pp.122-135.
F. Wang, JAD. Good, O. Rath, HYK. Kaan, OB. Sutcliffe, et al. (2012). Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity. J Med Chem. 55(4), pp.1511-1525.
LWL. Woo, D. Ganeshapillai, MP. Thomas, OB. Sutcliffe, B. Malini, et al. (2011). Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495). ChemMedChem. 6(11), pp.2019-2034.
EY. Santali, A-K. Cadogan, NN. Daeid, KA. Savage, OB. Sutcliffe (2011). Synthesis, full chemical characterisation and development of validated methods for the quantification of (±)-4′-methylmethcathinone (mephedrone): A new “legal high”. Journal of Pharmaceutical and Biomedical Analysis. 56(2), pp.246-255.
GJ. Kirkpatrick, JA. Plumb, OB. Sutcliffe, DJ. Flint, NJ. Wheate (2011). Evaluation of anionic half generation 3.5–6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin. Journal of Inorganic Biochemistry. 105(9), pp.1115-1122.
J. Baiget, S. Llona-Minguez, S. Lang, SP. MacKay, CJ. Suckling, et al. (2011). Manganese dioxide mediated one-pot synthesis of methyl 9 H -pyrido[3,4- b ]indole-1-carboxylate: Concise synthesis of alangiobussinine. Beilstein Journal of Organic Chemistry. 7, pp.1407-1411.
R. L. Clark, B. F. Johnston, S. P. Mackay, C. J. Breslin, M. N. Robertson, et al. (2010). The Drug Discovery Portal: A Computational Platform for Identifying Drug Leads from Academia. Current Pharmaceutical Design. 16(15), pp.1697-1702.
NJ. Wheate, N. Patel, OB. Sutcliffe (2010). Microwave synthesis of cucurbit[ n ]urils. Future Medicinal Chemistry. 2(2), pp.231-236.
C. Bubert, LWL. Woo, OB. Sutcliffe, MF. Mahon, SK. Chander, et al. (2008). Synthesis of Aromatase Inhibitors and Dual Aromatase Steroid Sulfatase Inhibitors by Linking an Arylsulfamate Motif to 4-(4 H -1,2,4-triazol-4-ylamino)benzonitrile: SAR, Crystal Structures, in vitro and in vivo Activities. ChemMedChem. 3(11), pp.1708-1730.
PA. Foster, SK. Chander, SP. Newman, LWL. Woo, OB. Sutcliffe, et al. (2008). A new therapeutic strategy against hormone-dependent breast cancer: the preclinical development of a dual aromatase and sulfatase inhibitor. Clin Cancer Res. 14(20), pp.6469-6477.
LWL. Woo, C. Bubert, OB. Sutcliffe, A. Smith, SK. Chander, et al. (2007). Dual Aromatase−Steroid Sulfatase Inhibitors. Journal of Medicinal Chemistry. 50(15), pp.3540-3560.
MD. Lloyd, N. Thiyagarajan, YT. Ho, LWL. Woo, OB. Sutcliffe, et al. (2005). First Crystal Structures of Human Carbonic Anhydrase II in Complex with Dual Aromatase−Steroid Sulfatase Inhibitors † , ‡. Biochemistry. 44(18), pp.6858-6866.
OB. Sutcliffe, MR. Bryce (2003). Planar chiral 2-ferrocenyloxazolines and 1,1′-bis(oxazolinyl)ferrocenes—syntheses and applications in asymmetric catalysis. Tetrahedron: Asymmetry. 14(16), pp.2297-2325.
LWL. Woo, OB. Sutcliffe, C. Bubert, A. Grasso, SK. Chander, et al. (2003). First Dual Aromatase-Steroid Sulfatase Inhibitors. Journal of Medicinal Chemistry. 46(15), pp.3193-3196.
OB. Sutcliffe, MR. Bryce, AS. Batsanov (2002). Synthesis of novel chiral bis(ferrocenyl) ligands and their use as voltammetric metal cation sensors. Journal of Organometallic Chemistry. 656(1-2), pp.211-216.
OB. Sutcliffe, A. Chesney, MR. Bryce (2001). Voltammetric metal cation sensors based on ferrocene derivatives with oxazoline and imine substituents. Journal of Organometallic Chemistry. 637-639, pp.134-138.
OB. Sutcliffe, RC. Storr, TL. Gilchrist, P. Rafferty (2001). Azafulvenium methides: new extended dipolar systems. Journal of the Chemical Society, Perkin Transactions 1. pp.1795-1806.
OB. Sutcliffe, RC. Storr, TL. Gilchrist, P. Rafferty (2000). Cycloadditions to Pyrrolo[1,2-c]thiazoles and Pyrazolo[1,5-c]thiazoles. Tetrahedron. 56(51), pp.10011-10021.
OB. Sutcliffe, RC. Storr, TL. Gilchrist, P. Rafferty, APA. Crew (2000). Azafulvenium methides: new extended dipolar systems. Chemical Communications. pp.675-676.
C. Pearson, OB. Sutcliffe, KJ. Shaw (2016). The M-CAT's out of the bag: A paper-based microfluidic immunoassay for the rapid detection of mephedrone. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. pp.966-967.
P. Holmes, L. McNeill, OB. Sutcliffe, KJ. Shaw (2016). Guilty by dissociation: Paper-fluidic presumptive testing of the new psychoactive substance, diphenidine. In: 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016. pp.972-973.