Biomedical Science
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Christopher Broughton
Tutor
Tutor in the Department of Life Sciences, teaching across Undergraduate and Masters courses in Biomedical Science and Human Physiology
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My profile
Biography
I am a molecular biology researcher with an interest in haemato-oncology, specifically B cell malignancies. I have a background in NHS clinical research and extensive teaching experience in a broad range of topics across Biomedical Science and Physiology.
Interests and expertise
Interests
- B cell malignancies
- B cell receptor signalling
- Drug repurposing
- Cell cycle checkpoint control
- Tubulin dynamics
Expertise
- Cell culture
- Microscopy (brightfield/confocal)
- Flow cytometry (apoptosis/cell cycle)
- RT-qPCR
- Multiplex western blotting
Projects
My PhD project (DoS: Dr Nina Dempsey) investigated the use of novel thienopyridine compounds as potential anti-cancer agents in B cell maligancies.
Teaching
Human Physiology
Muscle and bone. Brains and biochemistry. The fuel we consume and the air we breathe. Develop an expert understanding of the systems and organs that make humans tick. Our MSc Human Physiology degree o…
Research outputs
British Society for Haematology (BSH) Virtual ASM, Online 2020, Poster Presentation
- Broughton, C., Edwards, K., Whitehead, K., Van Rensburg M., Pilkington L., Reynisson J., Barker D., Dempsey-Hibbert, N. (2020) ‘BSH2020-EP-085 Novel synthetic thienopyridine derivatives induce tubulin disruption and cell cycle arrest in malignant B cells with level of activity related to their chemical structure’, British Journal of Haematology, 189(Suppl. 1), pp. 227-228
European Hematology Association (BSH) Virtual Congress, Online 2020, Poster Presentation
- Broughton, C., Edwards, K., Whitehead, K., Van Rensburg M., Pilkington L., Reynisson J., Barker D., Dempsey-Hibbert, N. (2020) ‘PB1899 Novel Thienopyridine Derivatives Induce Tubulin Disruption, Cause Cell Cycle Arrest And Inhibit Activation Of PLCG2 In Malignant B-Cells’, HemaSphere, 4(S1), pp. 865
European Hematology Association (EHA) Congress, Amsterdam 2019, Poster Presentation
- Broughton, C., Edwards, K., Whitehead, K., Van Rensburg M., Pilkington L., Reynisson J., Barker D., Dempsey-Hibbert, N. (2019) ‘PF523 Novel Thienopyridine Derivatives Induce Tubulin Disruption And Cause Cell Cycle Arrest In Malignant B-Cells’, HemaSphere, 3(S1), pp. 214
MMU Science & Engineering Research Symposium, Manchester 2017, Poster Presentation
- Broughton, C., Graham, C., Whitehead, K., Dempsey-Hibbert, N. (2017) ‘In-vitro effects of novel thienopyridine and thiazinoquinone derivatives on immortalised cancer cell lines’.
European Group for Blood and Marrow Transplantation (EBMT) Conference, Paris 2011, Poster Presentation
- Yin, J.A., Tholouli, E., Lucas, G., Goldstone, J., Narayan, S., Kok-Shun, J., Natarajan, S., Choudhuri, S., Broughton, C., Waller, M., Hurlin, J., Smith, E., Deakin, D., Lenehan, H., and Adams, J. (2011) ‘Outcome Of HSC Transplantation For Leukaemia After Myeloablative Conditioning Using TBI (1,000 CGY) Delivered In 2 Fractions, The Manchester Royal Infirmary, UK, Experience’, Bone Marrow Transplantation, 46, pp. S272-S272.