Dr Fiona Wilkinson

Astley, C., Houacine, C., Zaabalawi, A., Wilkinson, F., Lightfoot, A.P., Alexander, Y., Whitehead, D., Singh, K.K., Azzawi, M. (2021) 'Nanostructured lipid carriers deliver resveratrol, restoring attenuated dilation in small coronary arteries, via the AMPK pathway.' Biomedicines, 9(12)

Pang, K.T., Ghim, M., Liu, C., Tay, H.M., Fhu, C.W., Chia, R.N., Qiu, B., Sarathchandra, P., Chester, A.H., Yacoub, M.H., Wilkinson, F.L., Weston, R., Warboys, C.M., Hou, H.W., Weinberg, P.D., Wang, X. (2021) 'Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor.' Frontiers in Cell and Developmental Biology, 9pp. 706143-706143.

Pilkington, J.J., Davies, T.W., Schaff, O., Alexander, M.Y., Pritchett, J., Wilkinson, F.L., Sheen, A.J. (2021) 'Systemic biomarkers currently implicated in the formation of abdominal wall hernia: A systematic review of the literature.' American Journal of Surgery, 222(1) pp. 56-66.

Gill, D.M., Ana, A.P., Zazeri, G., Shamir, S.A., Mahmoud, A.M., Wilkinson, F.L., Alexander, M.Y., Cornelio, M.L., Jones, A.M. (2021) 'The modulatory role of sulfated and non-sulfated small molecule heparan sulfate-glycomimetics in endothelial dysfunction: absolute structural clarification, molecular docking and simulated dynamics, SAR analyses and ADMET studies.' RSC Medicinal Chemistry, 12(5) pp. 779-790.

Mahmoud, A.M., Wilkinson, F.L., Lightfoot, A.P., Dos Santos, J.M., Sandhu, M.A. (2021) 'The Role of Natural and Synthetic Antioxidants in Modulating Oxidative Stress in Drug-Induced Injury and Metabolic Disorders 2020.' Oxidative Medicine and Cellular Longevity, 2021

Alexander, Y., Osto, E., Schmidt-Trucksäss, A., Shechter, M., Trifunovic, D., Duncker, D.J., Aboyans, V., Bäck, M., Badimon, L., Cosentino, F., De Carlo, M., Dorobantu, M., Harrison, D.G., Guzik, T.J., Hoefer, I., Morris, P.D., Norata, G.D., Suades, R., Taddei, S., Vilahur, G., Waltenberger, J., Weber, C., Wilkinson, F., Bochaton-Piallat, M.L., Evans, P.C. (2021) 'Endothelial function in cardiovascular medicine: A consensus paper of the European Society of Cardiology Working Groups on Atherosclerosis and Vascular Biology, Aorta and Peripheral Vascular Diseases, Coronary Pathophysiology and Microcirculation, and Thrombosis.' Cardiovascular Research, 117(1) pp. 29-42.

Mahmoud, A.M., Wilkinson, F.L., Sandhu, M.A., Lightfoot, A.P. (2021) 'The Interplay of Oxidative Stress and Inflammation: Mechanistic Insights and Therapeutic Potential of Antioxidants.' Oxidative Medicine and Cellular Longevity, 2021

Yang, C., Eleftheriadou, M., Kelaini, S., Morrison, T., González, M.V., Caines, R., Edwards, N., Yacoub, A., Edgar, K., Moez, A., Ivetic, A., Zampetaki, A., Zeng, L., Wilkinson, F.L., Lois, N., Stitt, A.W., Grieve, D.J., Margariti, A. (2020) 'Targeting QKI-7 in vivo restores endothelial cell function in diabetes.' Nature Communications, 11(1)

Yang, C., Eleftheriadou, M., Kelaini, S., Morrison, T., González, M.V., Caines, R., Edwards, N., Yacoub, A., Edgar, K., Moez, A., Ivetic, A., Zampetaki, A., Zeng, L., Wilkinson, F.L., Lois, N., Stitt, A.W., Grieve, D.J., Margariti, A. (2020) 'Author Correction: Targeting QKI-7 in vivo restores endothelial cell function in diabetes (Nature Communications, (2020), 11, 1, (3812), 10.1038/s41467-020-17468-y).' Nature Communications, 11(1)

Bartoli-Leonard, F., Wilkinson, F.L., Schiro, A., Inglott, F.S., Alexander, M.Y., Weston, R. (2020) 'Loss of SIRT1 in diabetes accelerates DNA damage induced vascular calcification.' Cardiovascular Research, 117(3) pp. 836-849.

Parker, H., Ellison, S.M., Holley, R.J., O'Leary, C., Liao, A., Asadi, J., Glover, E., Ghosh, A., Jones, S., Wilkinson, F.L., Brough, D., Pinteaux, E., Boutin, H., Bigger, B.W. (2020) 'Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA.' EMBO Molecular Medicine, 12(3)

Langford-Smith, A.W.W., Hasan, A., Weston, R., Edwards, N., Jones, A.M., Boulton, A.J.M., Bowling, F.L., Rashid, S.T., Wilkinson, F.L., Alexander, M.Y. (2019) 'Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics.' Scientific Reports, 9(1)

Mitsides, N., Alsehli, F.M.S., Mc Hough, D., Shalamanova, L., Wilkinson, F., Alderdice, J., Mitra, R., Swiecicka, A., Brenchley, P., Parker, G.J.M., Alexander, M.Y., Mitra, S. (2019) 'Salt and Water Retention Is Associated with Microinflammation and Endothelial Injury in Chronic Kidney Disease.' Nephron, 143(4) pp. 234-242.

Mahmoud, A.M., Jones, A.M., Sidgwick, G.P., Arafat, A.M., Alexander, Y.M., Wilkinson, F.L. (2019) 'Small Molecule Glycomimetics Inhibit Vascular Calcification via c-Met/Notch3/HES1 Signalling.' Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 53(2) pp. 323-336.

Yu, K., Youshani, A.S., Wilkinson, F.L., O'Leary, C., Cook, P., Laaniste, L., Liao, A., Mosses, D., Waugh, C., Shorrock, H., Pathmanaban, O., Macdonald, A., Kamaly-Asl, I., Roncaroli, F., Bigger, B.W. (2019) 'A non-myeloablative chimeric mouse model accurately defines microglia and macrophage contribution in glioma..' Neuropathology and Applied Neurobiology, 45(2) pp. 119-140.

Bartoli-Leonard, F., Wilkinson, F.L., Schiro, A., Inglott, F.S., Alexander, M.Y., Weston, R. (2019) 'Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling.' Scientific Reports, 9(1)

Mahmoud, A.M., Wilkinson, F.L., Sandhu, M.A., Dos Santos, J.M., Yvonne Alexander, M. (2019) 'Modulating oxidative stress in drug-induced injury and metabolic disorders: The role of natural and synthetic antioxidants.' Oxidative Medicine and Cellular Longevity, 2019

Bartoli-Leonard, F., Wilkinson, F.L., Langford-Smith, A.W.W., Alexander, M.Y., Weston, R. (2018) 'The Interplay of SIRT1 and Wnt Signaling in Vascular Calcification.' Frontiers in Cardiovascular Medicine, 5

Edwards, N., Langford-Smith, A., Parker, B., Bruce, I., Reynolds, J., Alexander, Y., McCarthy, E., Wilkinson, F. (2018) 'QRISK3 improves detection of cardiovascular disease risk in patients with systemic lupus erythematosus.' Lupus Science & Medicine, 5(1) pp. 1-6.

Edwards, N., Langford-Smith, A.W.W., Wilkinson, F.L., Alexander, M.Y. (2018) 'Endothelial Progenitor Cells: New Targets for Therapeutics for Inflammatory Conditions With High Cardiovascular Risk..' Frontiers in medicine, 5pp. 1-11.

Holley, R.J., Ellison, S.M., Fil, D., O'Leary, C., McDermott, J., Senthivel, N., Langford-Smith, A., Wilkinson, F.L., D'Souza, Z., Parker, H., Liao, A., Rowlston, S., Gleitz, H., Kan, S., Dickson, P., Bigger, B.W. (2018) 'Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy.' Brain, 141(1) pp. 99-116.

Mahmoud, A.M., Alexander, M.Y., Tutar, Y., Wilkinson, F.L., Venditti, A. (2017) 'Oxidative Stress in Metabolic Disorders and Drug-Induced Injury: The Potential Role of Nrf2 and PPARs Activators.' Oxidative Medicine and Cellular Longevity, 2017pp. 1-4.

Mahmoud, A.M., Wilkinson, F.L., McCarthy, E.M., Moreno-Martinez, D., Langford-Smith, A., Romero, M., Duarte, J., Alexander, M.Y. (2017) 'Endothelial microparticles prevent lipid-induced endothelial damage via Akt/eNOS signaling and reduced oxidative stress..' The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(10) pp. 4636-4648.

Satta, S., Mahmoud, A.M., Wilkinson, F.L., Alexander, Y., White, S.J. (2017) 'The Role of Nrf2 in Cardiovascular Function and Disease.' Oxidative Medicine and Cellular Longevity, 2017

McCarthy, E.M., Moreno-Martinez, D., Wilkinson, F.L., McHugh, N.J., Bruce, I.N., Pauling, J.D., Alexander, Y., Parker, B. (2017) 'Microparticle subpopulations are potential markers of disease progression and vascular dysfunction across a spectrum of connective tissue disease.' BBA Clinical, 7pp. 16-22.

Mahmoud, A.M., Wilkinson, F., Wilkinson, J.A., Romero, M., Duarte, J., Alexander, Y., Jones, A.M. (2016) 'A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: involvement of Akt/eNOS and Nrf2/ARE signaling.' Biochimica et Biophysica Acta (BBA) - General Subjects, 1861(1) pp. 3311-3322.

Wilkinson, F.L., Mahmoud, A.M., Jones, A.M., Wilkinson, J.A., Romero, M., Duarte, J., Alexander, M.Y. (2016) 'A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction.' Cardiovascular Research, 111(S1) pp. S65-S65.

McCarthy, E.M., Wilkinson, F.L., Parker, B., Alexander, M.Y. (2016) 'Endothelial microparticles: Pathogenic or passive players in endothelial dysfunction in autoimmune rheumatic diseases?.' Vascular Pharmacology, 86pp. 71-76.

Schiro, A., Wilkinson, F.L., Weston, R., Smyth, J.V., Serracino-Inglott, F., Alexander, M.Y. (2015) 'Elevated levels of endothelial-derived microparticles, and serum CXCL9 and SCGF-β are associated with unstable asymptomatic carotid plaques..' Scientific Reports, 5

Weston, R., Sidgwick, G.P., Ahmed, N., Nazhad, N., Schiro, A., Wilkinson, F.L., Alexander, M.Y. (2015) 'Glycation and vascular calcification: developing an anti-calcification strategy.' Heart, 101pp. A14-A14.

Martins, C., Hulková, H., Dridi, L., Dormoy-Raclet, V., Grigoryeva, L., Choi, Y., Langford-Smith, A., Wilkinson, F.L., Ohmi, K., DiCristo, G., Hamel, E., Ausseil, J., Cheillan, D., Moreau, A., Svobodová, E., Hájková, Z., Tesarǒvá, M., Hansíková, H., Bigger, B.W., Hrebícek, M., Pshezhetsky, A.V. (2015) 'Erratum: Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model ((Brain (2015) DOI: 10.1093/brain/awu355).' Brain, 138(7)

Martins, C., Hulkova, H., Dridi, L., Dormoy-Raclet, V., Grigoryeva, L., Choi, Y., Langford-Smith, A., Wilkinson, F.L., Ohmi, K., DiCristo, G., Hamel, E., Ausseil, J., Cheillan, D., Moreau, A., Svobodova, E., Hajkova, Z., Tesarova, M., Hansikova, H., Bigger, B.W., Hrebicek, M., Pshezhetsky, A.V. (2015) 'Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model.' Brain, 138

Watson, H.A., Holley, R.J., Langford-Smith, K.J., Wilkinson, F.L., Van Kuppevelt, T.H., Wynn, R.F., Wraith, J.E., Merry, C.L.R., Bigger, B.W. (2014) 'Heparan Sulfate Inhibits Hematopoietic Stem and Progenitor Cell Migration and Engraftment in Mucopolysaccharidosis I.' Journal of Biological Chemistry, 289(52) pp. 36194-36203.

Ndip, A., Wilkinson, F.L., Jude, E.B., Boulton, A.J.M., Alexander, M.Y. (2014) 'RANKL-OPG and RAGE modulation in vascular calcification and diabetes: novel targets for therapy..' Diabetologia, 57(11) pp. 2251-2260.

Schiro, A., Wilkinson, F.L., Weston, R., Smyth, J.V., Serracino-Inglott, F., Alexander, M.Y. (2014) 'Endothelial microparticles as conveyors of information in atherosclerotic disease..' Atherosclerosis, 234(2) pp. 295-302.

Langford-Smith, K.J., Sandiford, Z., Langford-Smith, A., Wilkinson, F.L., Jones, S.A., Wraith, J.E., Wynn, R.F., Bigger, B.W. (2013) 'Signal One and Two Blockade Are Both Critical for Non-Myeloablative Murine HSCT across a Major Histocompatibility Complex Barrier.' PLoS ONE, 8(10)

Sergijenko, A., Langford-Smith, A., Liao, A.Y., Pickford, C.E., McDermott, J., Nowinski, G., Langford-Smith, K.J., Merry, C.L., Jones, S.A., Wraith, J.E., Wynn, R.F., Wilkinson, F.L., Bigger, B.W. (2013) 'Myeloid/Microglial driven autologous hematopoietic stem cell gene therapy corrects a neuronopathic lysosomal disease.' Molecular Therapy, 21(10) pp. 1938-1949.

Denes, A., Wilkinson, F., Bigger, B., Chu, M., Rothwell, N.J., Allan, S.M. (2013) 'Central and haematopoietic interleukin-1 both contribute to ischaemic brain injury in mice.' DMM Disease Models and Mechanisms, 6(4) pp. 1043-1048.

Wilkinson, F.L., Sergijenko, A., Langford-Smith, K.J., Malinowska, M., Wynn, R.F., Bigger, B.W. (2013) 'Erratum: Busulfan conditioning enhances engraftment of hematopoietic donor-derived cells in the brain compared with irradiation (Molecular Therapy (2013) 21 (868-876) DOI: 10.1038/mt.2013.29).' Molecular Therapy, 21(7)

Wilkinson, F.L., Sergijenko, A., Langford-Smith, K.J., Malinowska, M., Wynn, R.F., Bigger, B.W. (2013) 'Busulfan Conditioning Enhances Engraftment of Hematopoietic Donor-derived Cells in the Brain Compared With Irradiation.' MOLECULAR THERAPY, 21(4) pp. 868-876.

Langford-Smith, A., Wilkinson, F.L., Langford-Smith, K.J., Holley, R.J., Sergijenko, A., Howe, S.J., Bennett, W.R., Jones, S.A., Wraith, J.E., Merry, C.L., Wynn, R.F., Bigger, B.W. (2012) 'Hematopoietic Stem Cell and Gene Therapy Corrects Primary Neuropathology and Behavior in Mucopolysaccharidosis IIIA Mice..' Molecular therapy : the journal of the American Society of Gene Therapy, 20(8) pp. 1610-1621.

Wilkinson, F.L., Holley, R.J., Langford-Smith, K.J., Badrinath, S., Liao, A., Langford-Smith, A., Cooper, J.D., Jones, S.A., Wraith, J.E., Wynn, R.F., Merry, C.L.R., Bigger, B.W. (2012) 'Neuropathology in Mouse Models of Mucopolysaccharidosis Type I, IIIA and IIIB.' PLOS ONE, 7(4)

Langford-Smith, A., Wilkinson, F.L., Langford-Smith, K.J., Holley, R.J., Sergijenko, A., Howe, S.J., Bennett, W.R., Jones, S.A., Wraith, J.E., Merry, C.L.R., Wynn, R.F., Bigger, B.W. (2012) 'Hematopoietic Stem Cell and Gene Therapy Corrects Primary Neuropathology and Behavior in Mucopolysaccharidosis IIIA Mice.' MOLECULAR THERAPY, 20(8) pp. 1610-1621.

Langford-Smith, A., Langford-Smith, K.J., Jones, S.A., Wynn, R.F., Wraith, J.E., Wilkinson, F.L., Bigger, B.W. (2011) 'Female Mucopolysaccharidosis IIIA Mice Exhibit Hyperactivity and a Reduced Sense of Danger in the Open Field Test.' PLOS ONE, 6(10)

Langford-Smith, A., Malinowska, M., Langford-Smith, K.J., Wegrzyn, G., Jones, S., Wynn, R., Wraith, J.E., Wilkinson, F.L., Bigger, B.W. (2011) 'Hyperactive behaviour in the mouse model of mucopolysaccharidosis IIIB in the open field and home cage environments.' GENES BRAIN AND BEHAVIOR, 10(6) pp. 673-682.

Malinowska, M., Wilkinson, F.L., Langford-Smith, K.J., Langford-Smith, A., Brown, J.R., Crawford, B.E., Vanier, M.T., Grynkiewicz, G., Wynn, R.F., Wraith, J.E., Wegrzyn, G., Bigger, B.W. (2010) 'Genistein Improves Neuropathology and Corrects Behaviour in a Mouse Model of Neurodegenerative Metabolic Disease.' PLOS ONE, 5(12)

Canal, M.M., Wilkinson, F.L., Cooper, J.D., Wraith, J.E., Wynn, R., Bigger, B.W. (2010) 'Circadian rhythm and suprachiasmatic nucleus alterations in the mouse model of mucopolysaccharidosis IIIB.' BEHAVIOURAL BRAIN RESEARCH, 209(2) pp. 212-220.

Malinowska, M., Wilkinson, F.L., Bennett, W., Langford-Smith, K.J., O'Leary, H.A., Jakobkiewicz-Banecka, J., Wynn, R., Wraith, J.E., Wegrzyn, G., Bigger, B.W. (2009) 'Genistein reduces lysosomal storage in peripheral tissues of mucopolysaccharide IIIB mice.' MOLECULAR GENETICS AND METABOLISM, 98(3) pp. 235-242.

Alam, M.U., Kirton, J.P., Wilkinson, F.L., Towers, E., Sinha, S., Rouhi, M., Vizard, T.N., Sage, A.P., Martin, D., Ward, D.T., Alexander, M.Y., Riccardi, D., Canfield, A.E. (2009) 'Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells.' CARDIOVASCULAR RESEARCH, 81(2) pp. 260-268.

Liu, Y., Wilkinson, F.L., Kirton, J.P., Jeziorska, M., Iizasa, H., Sai, Y., Nakashima, E., Heagerty, A.M., Canfield, A.E., Alexander, M.Y. (2007) 'Hepatocyte growth factor and c-Met expression in pericytes: implications for atherosclerotic plaque development.' JOURNAL OF PATHOLOGY, 212(1) pp. 12-19.

Wilkinson, F.L., Liu, Y., Rucka, A.K., Jeziorska, M., Hoyland, J.A., Heagerty, A.M., Canfield, A.E., Alexander, M.Y. (2007) 'Contribution of VCAF-positive cells to neovascularization and calcification in atherosclerotic plaque development.' JOURNAL OF PATHOLOGY, 211(3) pp. 362-369.

Canfield, A.E., Hadfield, K.D., Rock, C.F., Wylie, E.C., Wilkinson, F.L. (2007) 'HtrA1: a novel regulator of physiological and pathological matrix mineralization?.' BIOCHEMICAL SOCIETY TRANSACTIONS, 35pp. 669-671.

Kirton, J.P., Wilkinson, F.L., Canfield, A.E., Alexander, M.Y. (2006) 'Dexamethasone downregulates calcification-inhibitor molecules and accelerates osteogenic differentiation of vascular pericytes implications for vascular calcification.' CIRCULATION RESEARCH, 98(10) pp. 1264-1272.

Alexander, M.Y., Wilkinson, F.L., Kirton, J.P., Rock, C.F., Collett, G.D.M., Jeziorska, M., Smyth, J.V., Heagerty, A.M., Canfield, A.E. (2005) 'Identification and characterization of vascular calcification-associated factor, a novel gene upregulated during vascular calcification in vitro and in vivo.' ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 25(9) pp. 1851-1857.

Wilkinson, F.L., Holaska, J.M., Zhang, Z., Sharma, A., Manilal, S., Holt, I., Stamm, S., Wilson, K.L., Morris, G.E. (2003) 'Emerin interacts in vitro with the splicing-associated factor, YT521-B.' European Journal of Biochemistry, 270(11) pp. 2459-2466.

Wilkinson, F.L., Thi Man, N., Manilal, S.B., Thomas, P., Neal, J.W., Harper, P.S., Jones, A.L., Morris, G.E. (1999) 'Localization of rabbit huntingtin using a new panel of monoclonal antibodies.' Molecular Brain Research, 69(1) pp. 10-20.

Thomas, P., Wilkinson, F., Man, N.T., Harper, P.S., Neal, J.W., Morris, G.E., Lesley Jones, A. (1998) 'Full length huntingtin is not detected in intranuclear inclusions in Huntington's disease brain.' Biochemical Society Transactions, 26(3)

Man, N.T., Manilal, S.B., Wilkinson, F.L., Chan, P.N.Y., Morris, G.E. (1997) 'Monoclonal antibody studies of emery-dreifuss muscular dystrophy, myotonic dystrophy and huntington's disease gene products.' FASEB Journal, 11(9)

Ellison, S.M., Parker, H., Holley, R., O'Leary, C., Liao, A., Asadi, J., Glover, E., Ghosh, A., Jones, S., Wilkinson, F.L., Brough, D., Pinteaux, E., Boutin, H., Bigger, B. (2020) 'Haematopoietic Stem Cell Gene Therapy with IL-1Ra Prevents Cognitive Loss in Mucopolysaccharidosis IIIA Mice.' In 23rd Annual Meeting of the American-Society-for-Gene-and-Cell-Therapy. 28. ELECTR NETWORK, 12/5/2020 - 15/5/2020. CELL PRESS, pp. 306-306.

Edwards, N., Langford-Smith, A.W., Tandel, S., Parker, B., Bruce, I., Reynolds, J.A., Alexander, M.Y., McCarthy, E., Wilkinson, F.L. (2019) 'Improving patient stratification in systemic lupus erythematosus using endothelial microvesicles as novel biomarkers of cardiovascular risk.' 9. WILEY, pp. 103-103.

Edwards, N., Langford-Smith, A.W.W., Floren, M., Hasan, A., Weston, R., Rashid, S.T., Boulton, A., Bowling, F., Tan, W., Wilkinson, F.L., Alexander, M.Y. (2019) 'Mitochondrial Hyperactivity, Impaired Matrix Adhesion and Functional Activity in Endothelial Colony Forming Cells Isolated from Patients with Diabetic Foot Ulcers.' 33. SPRINGER, pp. 273-273.

Alexander, Y., Langford-Smith, A.W., Hassan, A., Edwards, N., Wilkinson, F.L. (2019) 'Endothelial Dysfunction in the Diabetic Patient and the Contribution by Circulating Endothelial Colony Forming Cells.' In 3rd Joint Meeting of the European-Society-for-Microcirculation (ESM) and the European-Vascular-Biology-Organization (EVBO). 56. Maastricht, NETHERLANDS, 15/4/2019 - 18/4/2019. KARGER, pp. 3-3.

Astley, C., Houacine, C., Wilkinson, F.L., Lightfoot, A., Singh, K., Whitehead, D., Alexander, Y., Azzawi, M. (2019) 'Resveratrol-Loaded Nanostructured Lipid Carriers Restore Dilator Function Following Acute Pressure Elevation, Ex Vivo.' In 3rd Joint Meeting of the European-Society-for-Microcirculation (ESM) and the European-Vascular-Biology-Organization (EVBO). 56. Maastricht, NETHERLANDS, 15/4/2019 - 18/4/2019. KARGER, pp. 7-7.

Bartoli-Leonard, F., Wilkinson, F.L., Alexander, Y., Weston, R. (2019) 'SIRT1 Deacetylation of p53 Inhibits Hyperglycaemic Induced Senescence in Vascular Smooth Muscle Cells.' In 3rd Joint Meeting of the European-Society-for-Microcirculation (ESM) and the European-Vascular-Biology-Organization (EVBO). 56. Maastricht, NETHERLANDS, 15/4/2019 - 18/4/2019. KARGER, pp. 11-11.

Edwards, N., Langford-Smith, A.W., Tandel, S., Parker, B., Bruce, I., Reynolds, J., Alexander, Y., McCarthy, E., Wilkinson, F.L. (2019) 'Improving Stratification of Cardiovascular Risk in Systemic Lupus Erythematosus using Endothelial Microvesicles as Novel Biomarkers.' In 3rd Joint Meeting of the European-Society-for-Microcirculation (ESM) and the European-Vascular-Biology-Organization (EVBO). 56. Maastricht, NETHERLANDS, 4/2019 - KARGER, pp. 32-33.

Langford-Smith, A.W.W., Floren, M., Hasan, A., Weston, R., Edwards, N., Rashid, S.T., Boulton, A., Bowling, F., Tan, W., Wilkinson, F.L., Alexander, M.Y. (2018) 'Altered matrix adhesion, impaired function and mitochondrial hyperactivity in endothelial colony-forming cells isolated from patients with diabetic foot ulcers.' In Matrix Biology Europe Meeting. 99. Manchester, ENGLAND, 21/7/2018 - 24/7/2018. WILEY, pp. A7-A8.

Langford-Smith, A.W.W., Floren, M., Wei, T., Hasan, A., Weston, R., Edwards, N., Wilkinson, F.L., Alexander, Y., Rashid, S.T., Bowling, F., Boulton, A. (2018) 'ALTERED MATRIX ADHESION, IMPAIRED FUNCTION AND MITOCHONDRIAL HYPERACTIVITY IN ENDOTHELIAL COLONY FORMING CELLS ISOLATED FROM PATIENTS WITH DIABETIC FOOT ULCERS.' In Annual Conference of the British-Cardiovascular-Society on High Performing Teams. 104. Manchester, ENGLAND, 4/6/2018 - 6/6/2018. BMJ PUBLISHING GROUP, pp. A85-A85.

Edwards, N., Langford-Smith, A.W.W., Parker, B., Bruce, I., Reynolds, J.A., Alexander, Y., McCarthy, E., Wilkinson, F.L. (2018) 'QRISK3 IMPROVES IDENTIFICATION OF ENDOTHELIAL DYSFUNCTION AND CARDIOVASCULAR DISEASE RISK IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.' In Annual Conference of the British-Cardiovascular-Society on High Performing Teams. 104. Manchester, ENGLAND, 4/6/2018 - 6/6/2018. BMJ PUBLISHING GROUP, pp. A106-A106.

Sidgwick, G.P., Weston, R., Jones, A.M., Wilkinson, F.L., Alexander, Y. (2017) 'NOVEL GLYCOMIMETICS INHIBIT GLY-LDL INDUCED SMOOTH MUSCLE CELL CALCIFICATION VIA CREB.' In Annual Conference of the British-Cardiovascular-Society (BCS). 103. Manchester, ENGLAND, 5/6/2017 - 7/6/2017. BMJ PUBLISHING GROUP, pp. A126-A126.

Yu, K.K.H., Youshani, A.S., Wilkinson, F.L., O'Leary, C., Pathmanaban, O.N., Kamaly-Asl, I.D., Roncaroli, F., Bigger, B. (2017) 'DEFINING BRAIN MICROGLIA VERSUS PERIPHERAL MACROPHAGES IN A MOUSE MODEL OF GLIOBLASTOMA USING A NON-MYELOABLATIVE CONDITIONING REGIMEN.' In 5th Quadrennial Meeting of the World-Federation-of-Neuro-Oncology-Societies (WFNOS). 19. Zurich, SWITZERLAND, 4/5/2017 - 7/5/2017. OXFORD UNIV PRESS INC, pp. 69-69.

Sidgwick, G., Weston, R., Jones, A.M., Wilkinson, F.L., Alexander, Y. (2017) 'Glycomimetics Reduce Vascular Calcification In Vitro via Regulation of CREB Phosphorylation.' In 2nd Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO). 54. Geneva, SWITZERLAND, 29/5/2017 - 1/6/2017. KARGER, pp. 24-24.

Wilkinson, F.L., Sidgwick, G.P., Walling, P., Shabbir, A., Weston, R., Jones, A.M., Alexander, M.Y. (2016) 'GLYCOMIMETICS: A NOVEL APPROACH TO PREVENT VASCULAR CALCIFICATION.' In Autumn Meeting of the British-Society-for-Cardiovascular-Research (BSCR). 102. Univ Leeds, Leeds, ENGLAND, 5/9/2016 - 6/9/2016. BMJ PUBLISHING GROUP, pp. A11-A11.

Wilkinson, F.L., Mahmoud, A., Jones, A.M., Wilkinson, J.A., Romero, M., Duarte, J., Alexander, Y. (2016) 'A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction.' In Congresses Frontiers in CardioVascular Biology 2016. 111. Florence, Italy, 8/7/2016 - 10/7/2016. Oxford University Press for European Society of Cardiology, pp. S65-S65.

Sidgwick, G.P., Walling, P., Shabbir, A., Weston, R., Schiro, A., Serracino-Inglott, F., Jones, A.M., Kamalov, M., Brimble, M.A., Wilkinson, F.L., Alexander, Y. (2016) 'Strategies for Inhibiting Advanced Glycation Endproduct (Age) Induced Vascular Calcification in a Smooth Muscle Cell Culture Model.' In BCS Annual Conference. ‘Prediction and Prevention’. 102. Manchester, England, 6/6/2016 - 8/6/2016. BMJ Publishing Group,

Wilkinson, F.L., Mahmoud, A.M., Jones, A.M., Wilkinson, J.A., Romero, M., Duarte, J., Alexander, Y. (2016) 'Glycomimetics; A Novel Class of Drugs to Protect Against Free Fatty Acid-Induced Endothelial Dysfunction.' In BCS Annual Conference. ‘Prediction and Prevention’. 102. Manchester, England, 6/6/2016 - 8/6/2016. BMJ Publishing Group,

Hasan, A., Weston, R., Wilkinson, F.L., Boulton, A., Rashid, T., Bowling, F., Alexander, M.Y.V. (2016) 'FUNCTIONAL DEFECTS IDENTIFIED IN OUTGROWTH ENDOTHELIAL CELLS FROM DIABETIC PATIENTS COMPARED TO HEALTHY CONTROLS.' In Annual Conference of the British-Cardiovascular-Society (BCS) on Prediction and Prevention. 102. Manchester, ENGLAND, 6/6/2016 - 8/6/2016. BMJ PUBLISHING GROUP, pp. A132-A132.

Sidgwick, G.P., Weston, R., Ahmad, N., Nazhad, N., Schiro, A., Inglott, F.S., Wilkinson, F.L., Alexander, M.Y. (2016) 'The plant extract Momordica charantia reduces expression of vascular calcification markers in a smooth muscle cell culture model.' 244. Elsevier, pp. E11-E11.

Wilkinson, F.L., Weston, R., Sidgwick, G.P., Ahmed, N., Nazhad, N., Schiro, A., Alexander, M.Y., Serracino-Inglott, F. (2015) 'Developing an approach to prevent vascular calcification.' In The Vascular Societies Annual Scientific Meeting. Bournemouth, UK, 11/11/2015 - 13/11/2015.

Mahmoud, A.M., Wilkinson, F., Jones, A.M., Wilkinson, J.A., Romero, M., Duarte, J., Alexander, Y. (2015) 'A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction.' In The British Society for Cardiovascular Research Autumn Meeting 2015. “Translation of cardiovascular science to the clinic”. 101. Glasgow, Scotland, 7/9/2015 - 8/9/2015. BMJ Publishing Group,

Feng, J., Rajeswaran, T., He, S., Wilkinson, F.L., Serracino-Inglott, F., Azzawi, M., Parikh, V., Miraftab, M., Alexander, M.Y. (2015) 'Investigation of the composition of arterial plaques based on arterial waveforms and material properties.' 2015-November. pp. 993-996.

Moreno-Martinez, D., Wilkinson, F.L., McCarthy, E., Mahmoud, A.M., Alexander, M.Y. (2015) 'ENDOTHELIAL MICROPARTICLES: INVESTIGATING THEIR ROLE ON ENDOTHELIAL CELLS IN VITRO.' In Autumn Meeting of the British-Society-for-Cardiovascular-Research - Translation of Cardiovascular Science to the Clinic. 101. Univ Glasgow, Glasgow, SCOTLAND, 7/9/2015 - 8/9/2015. BMJ PUBLISHING GROUP, pp. A12-A12.

Weston, R., Sidgwick, G.P., Ahmed, N., Nazhad, N., Schiro, A., Inglott, F.S., Wilkinson, F.L., Alexander, M.Y. (2015) 'GLYCATION AND VASCULAR CALCIFICATION: DEVELOPING AN ANTI-CALCIFICATION STRATEGY.' In Autumn Meeting of the British-Society-for-Cardiovascular-Research - Translation of Cardiovascular Science to the Clinic. 101. Univ Glasgow, Glasgow, SCOTLAND, 7/9/2015 - 8/9/2015. BMJ PUBLISHING GROUP, pp. A14-A14.

Mahmoud, A.M., Wilkinson, F.L., Moreno-Martinez, D., Jimenez, R., Duarte, J., Alexander, M.Y. (2015) 'ENDOTHELIAL MICROPARTICLES PREVENT LIPID-INDUCED ENDOTHELIAL DYSFUNCTION THROUGH ACTIVATION OF AKT/ENOS SIGNALLING PATHWAY AND ATTENUATION OF OXIDATIVE STRESS.' In British-Cardiac-Society (BCS) Annual Conference on Hearts and Genes. 101. Manchester, ENGLAND, 8/6/2015 - 10/6/2015. BMJ PUBLISHING GROUP, pp. A102-A102.

Wilkinson, F.L., Schiro, A., Weston, R., Smyth, J.V., Serracino-Inglott, F., Alexander, M.Y. (2014) 'ELEVATED ENDOTHELIAL MICROPARTICLES IN ASYMPTOMATIC PATIENTS: MARKERS OF UNSTABLE PLAQUES?.' In Autumn Meeting of the British-Society-for-Cardiovascular-Research (BSCR) on Cardiovascular Signalling in Health and Disease. 100. Univ Reading, Reading, ENGLAND, 8/9/2014 - 9/9/2014. BMJ PUBLISHING GROUP,

Moreno-Martinez, D., Wilkinson, F.L., Parker, B., Pieri, M., Barraclough, M., Bruce, I., Alexander, M.Y. (2014) 'ENDOTHELIAL MICROPARTICLES: COMPLEX STRUCTURES THAT HAVE POTENTIAL TO ATTENUATE OSTEOGENIC DIFFERENTIATION OF HUMAN SMOOTH MUSCLE CELLS.' In Autumn Meeting of the British-Society-for-Cardiovascular-Research (BSCR) on Cardiovascular Signalling in Health and Disease. 100. Univ Reading, Reading, ENGLAND, 8/9/2014 - 9/9/2014. BMJ PUBLISHING GROUP,

Sergijenko, A., Langford-Smith, A., Liao, A.Y., Johnson, C.E., McDermott, J., Wilkinson, F.L., Langford-Smith, K.J., Merry, C.L.R., Jones, S.A., Wraith, J.E., Wynn, R.F., Bigger, B.W. (2013) 'Myeloid driven stem cell gene therapy corrects a mouse model of Mucopolysaccharidiosis IIIA.' In Collaborative Congress of the European-Society-for-Gene-and-Cell-Therapy and the Spanish-Society-for-Gene-and-Cell-Therapy. 24. Madrid, SPAIN, 25/10/2013 - 28/10/2013. MARY ANN LIEBERT, INC, pp. A134-A134.

Wilkinson, F.L., Holley, R.F., Langford-Smith, K.J., Badrinath, S., Langford-Smith, A., Cooper, J.D., Jones, S.A., Wraith, J.E., Wynn, R.F., Merry, C.L.R., Bigger, B.W. (2012) 'NEUROPATHOLOGICAL CHANGES ARE MORE PRONOUNCED IN MOUSE MODELS OF MUCOPOLYSACCHARIDOSIS (MPS) TYPE IIIA AND IIIB OVER MPSI.' 35. SPRINGER, pp. S22-S22.

Langford-Smith, A., Sergijenko, A., Wilkinson, F.L., Langford-Smith, K.J., Liao, A., Jones, S.A., Wraith, J.E., Wynn, R.F., Bigger, B.W. (2012) 'LENTIVIRAL SGSH EXPRESSION FROM THE HUMAN CD11B PROMOTER IN TRANSPLANTED HAEMATOPOIETIC STEM CELLS FULLY CORRECTS BEHAVIOUR AND NEUROPATHOLOGY OF MUCOPOLYSACCHARIDOSIS IIIA MICE.' 35. SPRINGER, pp. S21-S21.

Watson, H.A., Holley, R.J., Langford-Smith, K.J., Wilkinson, F.L., van Kuppevelt, T.H., Wynn, R., Wraith, J.E., Merry, C.L.R., Bigger, B.W. (2011) 'Excess Heparan Sulphate Inhibits CXCL12-Mediated Hematopoietic Cell Migration and Engraftment After Bone Marrow Transplant in Mice with Mucopolysaccharidosis Type I.' In 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis. 118. San Diego, CA, 10/12/2011 - 13/12/2011. AMER SOC HEMATOLOGY, pp. 1715-1715.

Langford-Smith, A.W.W., Wilkinson, F.L., Langford-Smith, K.J., Bennett, W., Howe, S., Thrasher, A., Hemsley, K., Hopwood, J., Wraith, J.E., Wynn, R.F., Bigger, B.W. (2010) 'Lentiviral Vector-Mediated Stem Cell Gene Therapy for Mucopolysaccharidosis Type IIIA (MPSIIIA).' In 7th Annual Conference of the British-Society-for-Gene-Therapy. 21. Royal Holloway Univ London, Egham, ENGLAND, 29/3/2010 - 31/3/2010. MARY ANN LIEBERT INC, pp. 502-503.

Canfield, A.E., Hadfield, K.D., Rock, C.F., Wylie, E.C., Wilkinson, F.L. (2007) 'The serine protease HtrA1 regulates physiological and pathological matrix mineralisation.' In Joint British-Society-for-Matrix-Biology/Biochemical Society Focused Meeting. 88. Sheffield Hallam Univ, Sheffield, ENGLAND, 2/4/2007 - 3/4/2007. BLACKWELL PUBLISHING, pp. A82-A82.

Liu, Y., Wilkinson, F.L., Heagerty, A.M., Canfield, A.E., Alexander, M.Y. (2007) 'A potential role for hepatocyte growth factor in pathological neovascularisation associated with atherosclerotic plaque development.' In Joint Autumn Meeting of the British-Society-for-Cardiovascular-Research/British-Atherosclerosis-Society. 93. Univ Cambridge, Queens Coll, Cambridge, ENGLAND, 21/9/2006 - 22/9/2006. B M J PUBLISHING GROUP,

Kirton, J.P., Wilkinson, F.L., Canfield, A.E., Alexander, M.Y. (2006) 'In vitro mineralization of pericytes is accelerated by glucocorticoid treatment.' In Autumn Meeting of the British-Society-for-Matrix-Biology. 87. Univ Manchester, Hulme Hall, Manchester, ENGLAND, 12/9/2005 - 13/9/2005. BLACKWELL PUBLISHING, pp. A26-A27.

Wilkinson, F.L., Kirton, J.P., Heagerty, A.M., Canfield, A.E., Alexander, M.Y. (2005) 'VCAF, a novel gene associated with vascular calcified lesions.' In 10th Annual Meeting of the European-Council-for-Cardiovascular-Research. 46. Nice, FRANCE, 14/10/2005 - 16/10/2005. LIPPINCOTT WILLIAMS & WILKINS, pp. 892-892.

Wilkinson, F.L., Kirton, J.P., Heagerty, A.M., Canfield, A.E., Alexander, M.Y. (2005) 'Investigating the role of C15, a novel gene found in calcified arteries.' In Spring Meeting of the British-Atherosclerosis-Society-Medical-Sciences-Teaching-Center. 181. Magdalen Coll, Oxford, ENGLAND, 14/4/2005 - 15/4/2005. ELSEVIER IRELAND LTD, pp. S5-S6.

Wilkinson, F., Man, N., Morris, G.E. (1997) 'Monoclonal antibodies from three new regions of huntingtin, the Huntington's disease protein.' 25.