Dr Ria Weston

Sidgwick, G.P., Weston, R., Mahmoud, A.M., Schiro, A., Serracino-Inglott, F., Tandel, S.M., Skeoch, S., Bruce, I.N., Jones, A.M., Alexander, M.Y., Wilkinson, F.L. (2024) 'Novel Glycomimetics Protect against Glycated Low-Density Lipoprotein-Induced Vascular Calcification In Vitro via Attenuation of the RAGE/ERK/CREB Pathway.' Cells, 13(4)

Collins, M.T., Marcucci, G., Anders, H.J., Beltrami, G., Cauley, J.A., Ebeling, P.R., Kumar, R., Linglart, A., Sangiorgi, L., Towler, D.A., Weston, R., Whyte, M.P., Brandi, M.L., Clarke, B., Thakker, R.V. (2023) 'Author Correction: Skeletal and extraskeletal disorders of biomineralization (Nature Reviews Endocrinology, (2022), 18, 8, (473-489), 10.1038/s41574-022-00682-7).' Nature Reviews Endocrinology, 19(1)

Collins, M.T., Marcucci, G., Anders, H.J., Beltrami, G., Cauley, J.A., Ebeling, P.R., Kumar, R., Linglart, A., Sangiorgi, L., Towler, D.A., Weston, R., Whyte, M.P., Brandi, M.L., Clarke, B., Thakker, R.V. (2022) 'Skeletal and extraskeletal disorders of biomineralization.' Nature Reviews Endocrinology, 18(8) pp. 473-489.

Pang, K.T., Ghim, M., Liu, C., Tay, H.M., Fhu, C.W., Chia, R.N., Qiu, B., Sarathchandra, P., Chester, A.H., Yacoub, M.H., Wilkinson, F.L., Weston, R., Warboys, C.M., Hou, H.W., Weinberg, P.D., Wang, X. (2021) 'Leucine-Rich α-2-Glycoprotein 1 Suppresses Endothelial Cell Activation Through ADAM10-Mediated Shedding of TNF-α Receptor.' Frontiers in Cell and Developmental Biology, 9pp. 706143-706143.

Bartoli-Leonard, F., Wilkinson, F.L., Schiro, A., Inglott, F.S., Alexander, M.Y., Weston, R. (2020) 'Loss of SIRT1 in diabetes accelerates DNA damage induced vascular calcification.' Cardiovascular Research, 117(3) pp. 836-849.

Langford-Smith, A.W.W., Hasan, A., Weston, R., Edwards, N., Jones, A.M., Boulton, A.J.M., Bowling, F.L., Rashid, S.T., Wilkinson, F.L., Alexander, M.Y. (2019) 'Diabetic endothelial colony forming cells have the potential for restoration with glycomimetics.' Scientific Reports, 9(1)

Munnur, D., Somers, J., Skalka, G., Weston, R., Jukes-Jones, R., Bhogadia, M., Dominguez, C., Cain, K., Ahel, I., Malewicz, M. (2019) 'NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair.' Cell Reports, 26(8) pp. 2028-2036.e6.

Bartoli-Leonard, F., Wilkinson, F.L., Schiro, A., Inglott, F.S., Alexander, M.Y., Weston, R. (2019) 'Suppression of SIRT1 in Diabetic Conditions Induces Osteogenic Differentiation of Human Vascular Smooth Muscle Cells via RUNX2 Signalling.' Scientific Reports, 9(1)

Bartoli-Leonard, F., Wilkinson, F.L., Langford-Smith, A.W.W., Alexander, M.Y., Weston, R. (2018) 'The Interplay of SIRT1 and Wnt Signaling in Vascular Calcification.' Frontiers in Cardiovascular Medicine, 5

Liu, D., Zeinolabediny, Y., Caccuri, F., Ferris, G., Fang, W.H., Weston, R., Krupinski, J., Colombo, L., Salmona, M., Corpas, R., Sarroca, S., Sanfeliu, C., Caruso, A., Guo, B., Zeng, X., Slevin, M. (2018) 'p17 from HIV induces brain endothelial cell angiogenesis through EGFR-1-mediated cell signalling activation.' Laboratory Investigation, 99(2) pp. 180-190.

Khambalia, H.A., Alexander, M.Y., Nirmalan, M., Weston, R., Pemberton, P., Moinuddin, Z., Summers, A., van Dellen, D., Augustine, T. (2018) 'Links between a biomarker profile, cold ischaemic time and clinical outcome following simultaneous pancreas and kidney transplantation.' Cytokine, 105pp. 8-16.

Zeinolabediny, Y., Caccuri, F., Colombo, L., Morelli, F., Romeo, M., Rossi, A., Schiarea, S., Ciaramelli, C., Airoldi, C., Weston, R., Donghui, L., Krupinski, J., Corpas, R., García-Lara, E., Sarroca, S., Sanfeliu, C., Slevin, M., Caruso, A., Salmona, M., Diomede, L. (2017) 'HIV-1 matrix protein p17 misfolding forms toxic amyloidogenic assemblies that induce neurocognitive disorders.' Scientific Reports, 7(1)

Buga, A.M., Ciobanu, O., Badescu, G.M., Bogdan, C., Weston, R., Slevin, M., Di Napoli, M., Popa-Wagner, A. (2016) 'Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients.' Oncotarget, 7(14) pp. 17415-17430.

Schiro, A., Wilkinson, F.L., Weston, R., Smyth, J.V., Serracino-Inglott, F., Alexander, M.Y. (2015) 'Elevated levels of endothelial-derived microparticles, and serum CXCL9 and SCGF-β are associated with unstable asymptomatic carotid plaques.' Scientific Reports, 5

Khambalia, H., Alexander, Y., Nirmalan, M., Weston, R., Pemberton, P., Moinuddin, Z., Van Dellen, D., Augustine, T. (2015) 'THE CLINICAL UTILITY OF INFLAMMATORY AND DIABETES MARKERS POST- SIMULTANEOUS PANCREAS AND KIDNEY TRANSPLANTATION.' TRANSPLANT INTERNATIONAL, 28pp. 622-622.

Weston, R., Sidgwick, G.P., Ahmed, N., Nazhad, N., Schiro, A., Wilkinson, F.L., Alexander, M.Y. (2015) 'Glycation and vascular calcification: developing an anti-calcification strategy.' Heart, 101pp. A14-A14.

Slevin, M., Matou, S., Zeinolabediny, Y., Corpas, R., Weston, R., Liu, D., Boras, E., Di Napoli, M., Petcu, E., Sarroca, S., Popa-Wagner, A., Love, S., Font, M.A., Potempa, L.A., Al-Baradie, R., Sanfeliu, C., Revilla, S., Badimon, L., Krupinski, J. (2015) 'Monomeric C-reactive protein - A key molecule driving development of Alzheimer's disease associated with brain ischaemia?.' Scientific Reports, 5

Schiro, A., Wilkinson, F., Weston, R., Smyth, J.V., Boulton, A.J., Serracino-Inglott, F., Alexander, Y.M. (2014) 'THE ROLE OF MICROPARTICLES IN CAROTID DISEASE.' HEART, 100pp. A101-A101.

Schiro, A., Wilkinson, F.L., Weston, R., Smyth, J.V., Serracino-Inglott, F., Alexander, M.Y. (2014) 'Endothelial microparticles as conveyors of information in atherosclerotic disease..' Atherosclerosis, 234(2) pp. 295-302.

Sharifi, R., Morra, R., Denise Appel, C., Tallis, M., Chioza, B., Jankevicius, G., Simpson, M.A., Matic, I., Ozkan, E., Golia, B., Schellenberg, M.J., Weston, R., Williams, J.G., Rossi, M.N., Galehdari, H., Krahn, J., Wan, A., Trembath, R.C., Crosby, A.H., Ahel, D., Hay, R., Ladurner, A.G., Timinszky, G., Scott Williams, R., Ahel, I. (2013) 'Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.' EMBO Journal, 32(9) pp. 1225-1237.

Weston, R., Peeters, H., Ahel, D. (2012) 'ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response..' Genes Dev, 26(14) pp. 1558-1572.

Slade, D., Dunstan, M.S., Barkauskaite, E., Weston, R., Lafite, P., Dixon, N., Ahel, M., Leys, D., Ahel, I. (2011) 'The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase..' Nature, 477(7366) pp. 616-620.

Mehrotra, P.V., Ahel, D., Ryan, D.P., Weston, R., Wiechens, N., Kraehenbuehl, R., Owen-Hughes, T., Ahel, I. (2011) 'DNA repair factor APLF is a histone chaperone..' Mol Cell, 41(1) pp. 46-55.

Bartoli-Leonard, F., Alexander, Y., Weston, R. (2019) 'LOSS OF SIRT1 IN DIABETES ENHANCES DNA DAMAGE AND REDUCES MRN COMPLEX ACTIVATION RESULTING IN INCREASED VASCULAR CALCIFICATION.' In Annual Conference of the British-Cardiovascular-Society (BCS) - Digital Health Revolution. 105. Manchester, ENGLAND, 3/6/2019 - 5/6/2019. BMJ PUBLISHING GROUP, pp. A177-A178.

Edwards, N., Langford-Smith, A.W.W., Floren, M., Hasan, A., Weston, R., Rashid, S.T., Boulton, A., Bowling, F., Tan, W., Wilkinson, F.L., Alexander, M.Y. (2019) 'Mitochondrial Hyperactivity, Impaired Matrix Adhesion and Functional Activity in Endothelial Colony Forming Cells Isolated from Patients with Diabetic Foot Ulcers.' 33. SPRINGER, pp. 273-273.

Bartoli-Leonard, F., Wilkinson, F.L., Alexander, Y., Weston, R. (2019) 'SIRT1 Deacetylation of p53 Inhibits Hyperglycaemic Induced Senescence in Vascular Smooth Muscle Cells.' In 3rd Joint Meeting of the European-Society-for-Microcirculation (ESM) and the European-Vascular-Biology-Organization (EVBO). 56. Maastricht, NETHERLANDS, 15/4/2019 - 18/4/2019. KARGER, pp. 11-11.

Langford-Smith, A.W.W., Floren, M., Hasan, A., Weston, R., Edwards, N., Rashid, S.T., Boulton, A., Bowling, F., Tan, W., Wilkinson, F.L., Alexander, M.Y. (2018) 'Altered matrix adhesion, impaired function and mitochondrial hyperactivity in endothelial colony-forming cells isolated from patients with diabetic foot ulcers.' In Matrix Biology Europe Meeting. 99. Manchester, ENGLAND, 21/7/2018 - 24/7/2018. WILEY, pp. A7-A8.

Langford-Smith, A.W.W., Floren, M., Wei, T., Hasan, A., Weston, R., Edwards, N., Wilkinson, F.L., Alexander, Y., Rashid, S.T., Bowling, F., Boulton, A. (2018) 'ALTERED MATRIX ADHESION, IMPAIRED FUNCTION AND MITOCHONDRIAL HYPERACTIVITY IN ENDOTHELIAL COLONY FORMING CELLS ISOLATED FROM PATIENTS WITH DIABETIC FOOT ULCERS.' In Annual Conference of the British-Cardiovascular-Society on High Performing Teams. 104. Manchester, ENGLAND, 4/6/2018 - 6/6/2018. BMJ PUBLISHING GROUP, pp. A85-A85.

Bartoli-Leonard, F., Alexander, Y., Weston, R. (2018) 'SIRT1 ATTENUATES HYPERGLYCAEMIC INDUCED CALCIFICATION AND ASSOCIATED SENESCENCE IN VASCULAR SMOOTH MUSCLE CELLS.' In Annual Conference of the British-Cardiovascular-Society on High Performing Teams. 104. Manchester, ENGLAND, 4/6/2018 - 6/6/2018. BMJ PUBLISHING GROUP, pp. A92-A92.

Bartoli-Leonard, F., Alexander, Y., Weston, R. (2018) 'Novel small molecule SIRT1 activators attenuate vacsular calcification in an in vitro diabetic model.' In 5th Congress of the ESC-Council-on-Basic-Cardiovascular-Science on Frontiers in Cardio Vascular Biology. 114. Vienna, AUSTRIA, 20/4/2018 - 22/4/2018. OXFORD UNIV PRESS, pp. S91-S91.

Sidgwick, G.P., Weston, R., Jones, A.M., Wilkinson, F.L., Alexander, Y. (2017) 'NOVEL GLYCOMIMETICS INHIBIT GLY-LDL INDUCED SMOOTH MUSCLE CELL CALCIFICATION VIA CREB.' In Annual Conference of the British-Cardiovascular-Society (BCS). 103. Manchester, ENGLAND, 5/6/2017 - 7/6/2017. BMJ PUBLISHING GROUP, pp. A126-A126.

Weston, R., Smith, A.L., Hasan, A., Jones, A., Wilkinson, F., Boulton, A., Bowling, F., Rashid, T., Alexander, Y. (2017) 'Targeting outgrowth endothelial progenitor cell defective function using glycomimetics for improved diabetic wound healing.' 34. WILEY, pp. 39-39.

Sidgwick, G., Weston, R., Jones, A.M., Wilkinson, F.L., Alexander, Y. (2017) 'Glycomimetics Reduce Vascular Calcification In Vitro via Regulation of CREB Phosphorylation.' In 2nd Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO). 54. Geneva, SWITZERLAND, 29/5/2017 - 1/6/2017. KARGER, pp. 24-24.

Payton, N., Langford-Smith, A., Weston, R., Hasan, A., Jones, A., Boulton, A., Bowling, F., Rashid, S.T., Wilkinson, F., Alexander, M.Y. (2017) 'The Therapeutic Effects of a Novel Glycomimetic on the Function of Endothelial Colony Forming Progenitor Cells Isolated From Patients With Diabetic Foot Ulcers.' In 2nd Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO). 54. Geneva, SWITZERLAND, 29/5/2017 - 1/6/2017. KARGER, pp. 52-52.

Schiro, A., Wilkinson, F., Weston, R., Alexander, Y., Serracino-Inglott, F. (2016) 'EMPs are elevated in patients with unstable asymptomatic carotid plaques.' In Vascular-Societies Annual Scientific Meeting. 103. Bournemouth, ENGLAND, 11/11/2015 - 13/11/2015. WILEY-BLACKWELL, pp. 8-8.

Wilkinson, F.L., Sidgwick, G.P., Walling, P., Shabbir, A., Weston, R., Jones, A.M., Alexander, M.Y. (2016) 'GLYCOMIMETICS: A NOVEL APPROACH TO PREVENT VASCULAR CALCIFICATION.' In Autumn Meeting of the British-Society-for-Cardiovascular-Research (BSCR). 102. Univ Leeds, Leeds, ENGLAND, 5/9/2016 - 6/9/2016. BMJ PUBLISHING GROUP, pp. A11-A11.

Weston, R., Hasan, A., Wilkinson, F., Boulton, A., Rashid, T., Bowling, F., Alexander, M.Y. (2016) 'INVESTIGATING THE WOUND HEALING CAPACITY OF OUTGROWTH ENDOTHELIAL CELLS FROM DIABETIC NEUROPATHY AND NEUROISCHAEMIA PATIENTS.' In Autumn Meeting of the British-Society-for-Cardiovascular-Research (BSCR). 102. Univ Leeds, Leeds, ENGLAND, 5/9/2016 - 6/9/2016. BMJ PUBLISHING GROUP, pp. A5-A5.

Sidgwick, G.P., Walling, P., Shabbir, A., Weston, R., Schiro, A., Serracino-Inglott, F., Jones, A.M., Kamalov, M., Brimble, M.A., Wilkinson, F.L., Alexander, Y. (2016) 'Strategies for Inhibiting Advanced Glycation Endproduct (Age) Induced Vascular Calcification in a Smooth Muscle Cell Culture Model.' In BCS Annual Conference. ‘Prediction and Prevention’. 102. Manchester, England, 6/6/2016 - 8/6/2016. BMJ Publishing Group,

Hasan, A., Weston, R., Wilkinson, F.L., Boulton, A., Rashid, T., Bowling, F., Alexander, M.Y.V. (2016) 'FUNCTIONAL DEFECTS IDENTIFIED IN OUTGROWTH ENDOTHELIAL CELLS FROM DIABETIC PATIENTS COMPARED TO HEALTHY CONTROLS.' In Annual Conference of the British-Cardiovascular-Society (BCS) on Prediction and Prevention. 102. Manchester, ENGLAND, 6/6/2016 - 8/6/2016. BMJ PUBLISHING GROUP, pp. A132-A132.

Sidgwick, G.P., Weston, R., Ahmad, N., Nazhad, N., Schiro, A., Inglott, F.S., Wilkinson, F.L., Alexander, M.Y. (2016) 'The plant extract Momordica charantia reduces expression of vascular calcification markers in a smooth muscle cell culture model.' 244. Elsevier, pp. E11-E11.

Wilkinson, F.L., Weston, R., Sidgwick, G.P., Ahmed, N., Nazhad, N., Schiro, A., Alexander, M.Y., Serracino-Inglott, F. (2015) 'Developing an approach to prevent vascular calcification.' In The Vascular Societies Annual Scientific Meeting. Bournemouth, UK, 11/11/2015 - 13/11/2015.

Weston, R., Sidgwick, G.P., Ahmed, N., Nazhad, N., Schiro, A., Inglott, F.S., Wilkinson, F.L., Alexander, M.Y. (2015) 'GLYCATION AND VASCULAR CALCIFICATION: DEVELOPING AN ANTI-CALCIFICATION STRATEGY.' In Autumn Meeting of the British-Society-for-Cardiovascular-Research - Translation of Cardiovascular Science to the Clinic. 101. Univ Glasgow, Glasgow, SCOTLAND, 7/9/2015 - 8/9/2015. BMJ PUBLISHING GROUP, pp. A14-A14.

Khambalia, H., Alexander, Y., Nirmalan, M., Weston, R., Pemberton, P., Moinuddin, Z., van Dellen, D., Augustine, T. (2015) 'The clinical utility of inflammatory and diabetes markers post simultaneous pancreas and kidney transplantation.' In IPITA/IXA/CTS Joint Congress. 22. Melbourne, AUSTRALIA, 15/11/2015 - 19/11/2015. WILEY-BLACKWELL, pp. S126-S126.

Khambalia, H., Alexander, Y., Nirmalan, M., Weston, R., Pemberton, P., Moinuddin, Z., van Dellen, D., Augustine, T. (2015) 'THE CLINICAL UTILITY OF INFLAMMATORY AND DIABETES MARKERS POST SIMULTANEOUS PANCREAS AND KIDNEY TRANSPLANTATION..' In Joint Congress of the International-Pancreas-and-Islet-Transplantation-Association, International-Xenotransplantation-Association and Cell-Transplant-Society. 99. Melbourne, AUSTRALIA, 15/11/2015 - 19/11/2015. LIPPINCOTT WILLIAMS & WILKINS, pp. S210-S210.

Weston, R., Wilkinson, F., Liu, Y., Schofield, J., Siahmansur, T., Soran, H., Alexander, Y. (2015) 'GLYCATED LDL (GLYC-LDL) PROMOTES OSTEOGENIC DIFFERENTIATION OF VASCULAR SMOOTH MUSCLE CELLS.' In British-Cardiac-Society (BCS) Annual Conference on Hearts and Genes. 101. Manchester, ENGLAND, 8/6/2015 - 10/6/2015. BMJ PUBLISHING GROUP, pp. A117-A117.

Khambalia, H., Alexander, M.Y., Nirmalan, M., Weston, R., Pemberton, P., Moinuddin, Z., Summers, A., van Dellen, D., Augustine, T. (2015) 'The temporal evolution of inflammatory and diabetes biomarkers following simultaneous pancreas and kidney transplantation (NCT01619904).' In Annual Meeting of the Society-of-Academic-and-Research-Surgery (SARS(. 102. Durham Univ, Durham, ENGLAND, 7/1/2015 - 8/1/2015. WILEY-BLACKWELL, pp. 13-14.

Wilkinson, F., Schiro, A., Weston, R., Smyth, V., Ferdinand, S.I., Alexander, Y. (2015) 'ENDOTHELIAL MICROPARTICLES; A NOVEL BIOMARKER OF CAROTID DISEASE?.' In Joint Meeting of the European-Society-for-Microcirculation (ESM) and European-Vascular-Biology-Organisation (EVBO). 52. Pisa, ITALY, 3/6/2015 - 6/6/2015. KARGER, pp. 65-66.

Wilkinson, F.L., Schiro, A., Weston, R., Smyth, J.V., Serracino-Inglott, F., Alexander, M.Y. (2014) 'ELEVATED ENDOTHELIAL MICROPARTICLES IN ASYMPTOMATIC PATIENTS: MARKERS OF UNSTABLE PLAQUES?.' In Autumn Meeting of the British-Society-for-Cardiovascular-Research (BSCR) on Cardiovascular Signalling in Health and Disease. 100. Univ Reading, Reading, ENGLAND, 8/9/2014 - 9/9/2014. BMJ PUBLISHING GROUP,