Dr Sarah Jones
Senior Lecturer
My profile
Biography
Academic and professional qualifications
- PGCert (Distinction)
- FHEA
External examiner roles
External PhD examiner
Expert reviewer for external funding bodies
Review manuscripts for Journal of Thrombosis and Haemostasis, Hypertension, Platelets, Scientific Reports, British Journal of Pharmacology, Placenta
Review Grants for BHF, MRC and BBSRC
Teaching
Postgraduate teaching
Unit Leader:
- Haemostasis (MSc and STP)
Teaching:
- Introduction to Blood Science
- Haemostasis
- Clinical Haematology
Research outputs
Dr Sarah Jones has over 15 years experience researching platelet biology and the activatory and inhibitory signalling mechanisms involved in the fine tuning of platelet responses in thrombosis and haemostasis. Recent work in Dr Jones’ lab has focussed on the cross-talk between platelets and endothelial cells and how the ‘health’ of the endothelium dictates thrombotic responses, as well as influencing the efficacy of standard antithrombotic treatments. Current studies include developing endothelialized in vitro models of thrombosis with exposed extracellular matrices and endothelial cell phenotype relevant to cardiovascular disease, or pathogen induced thromboinflammation, to facilitate the discovery of novel therapeutic interventions.
Dr Jones also has an interest in endothelial ‘health’ in the placental circulation and how this impacts on fetal growth and development. Previous work has demonstrated endothelial dysfunction in placenetal vessels in pregnancies complicated by fetal growth restriction (FGR), with aboloished flow mediated vasodilatation. Current work is focussued on investigating whether vascular changes in FGR promote a pro-thrombotic environment potentially leading to placental thromboses and a poor outcome.
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Chapters in books
Jones, S. (2015) 'Measurement of intracellular ca2+ in human endothelial cells.' Handbook of Vascular Biology Techniques. pp. 95-106.
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Journal articles
Drysdale, A., Blanco-Lopez, M., White, S.J., Unsworth, A.J., Jones, S. (2024) 'Differential proteoglycan expression in atherosclerosis alters platelet adhesion and activation.' International Journal of Molecular Sciences, 25(2)
Drysdale, A., Zaabalawi, A., Jones, S. (2024) 'Modelling arterial thrombus formation in vitro.' Current Opinion in Hematology, 31(1) pp. 16-23.
George, C.E., Saunders, C.V., Morrison, A., Scorer, T., Jones, S., Dempsey, N.C. (2023) 'Cold stored platelets in the management of bleeding: is it about bioenergetics?.' Platelets, 34(1) pp. 2188969-2188969.
Drysdale, A., Unsworth, A.J., White, S.J., Jones, S. (2023) 'The contribution of vascular proteoglycans to atherothrombosis: clinical implications.' International Journal of Molecular Sciences, 24(14) pp. 11854-11854.
Zabel, R.R., Favaro, R.R., Groten, T., Brownbill, P., Jones, S. (2022) 'Ex vivo perfusion of the human placenta to investigate pregnancy pathologies.' Placenta, 130pp. 1-8.
Wang, S., Hu, S., Luo, X., Bao, X., Li, J., Liu, M., Lv, Y., Zhao, C., Zeng, M., Chen, X., Unsworth, A., Jones, S., Johnson, T.W., White, S.J., Jia, H., Yu, B. (2022) 'Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction.' EBioMedicine, 78pp. 103964-103964.
Kriek, N., Nock, S., Sage, T., Khalifa, B., Bye, A.P., Mitchell, J., Thomson, S., McLaughlin, M., Jones, S., Gibbins, J., Unsworth, A. (2022) 'Cucurbitacins elicit anti-platelet activity via perturbation of the actin cytoskeleton and integrin function.' Thrombosis and Haemostasis,
Wright, J.R., Jones, S., Parvathy, S., Kaczmarek, L.K., Forsythe, I., Farndale, R.W., Gibbins, J.M., Mahaut-Smith, M.P. (2021) 'The voltage-gated K+ channel Kv1.3 modulates platelet motility and α2β1 integrin-dependent adhesion to collagen.' Platelets, 33(3) pp. 451-461.
Unsworth, A., Bye, A., Sage, T., Gasper, R., Eaton, N., Drew, C., Stainer, A., Kriek, N., Volberding, P., Hutchinson, J., Riley, R., Jones, S., Mundell, S., Cui, W., Falet, H., Gibbins, J. (2020) 'Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling..' Haematologica: the hematology journal, 105
Brook, A., Hoaksey, A., Gurung, R., Yoong, E.E.C., Sneyd, R., Baynes, G.C., Bischof, H., Jones, S., Higgins, L.E., Jones, C., Greenwood, S.L., Jones, R.L., Gram, M., Lang, I., Desoye, G., Myers, J., Schneider, H., Hansson, S.R., Crocker, I.P., Brownbill, P. (2019) 'Correction to: Cell free hemoglobin in the fetoplacental circulation: a novel cause of fetal growth restrictionss (The FASEB Journal, (2019), 33, 5, (6682), 10.1096/fj.201800264RERR).' FASEB Journal, 33(5)
Brook, A., Hoaksey, A., Gurung, R., Yoong, E.E.C., Sneyd, R., Baynes, C.G., Bischof, H., Jones, S., Higgins, L.E., Jones, C., Greenwood, S.L., Jones, R.L., Gram, M., Lang, I., Desoye, G., Myers, J., Schneider, H., Hansson, S.R., Crocker, I.P., Brownbill, P. (2018) 'Cell free hemoglobin in the fetoplacental circulation: a novel cause of fetal growth restriction?.' The FASEB Journal, 32(10) pp. 5436-5446.
Binsaleh, N.K., Wigley, C.A., Vagg-Whitehead, K., van Rensburg, M., Reynisson, J., Pilkington, L.I., Barker, D., Jones, S., Dempsey-Hibbert, N. (2018) 'Thieno[2,3-b]pyridine derivatives are potent anti-platelet drugs, inhibiting platelet activation, aggregation and showing synergy with aspirin.' European Journal of Medicinal Chemistry, 143pp. 1997-2004.
Jones, S., Bischof, H., Lang, I., Desoye, G., Greenwood, S.L., Johnstone, E.D., Wareing, M., Sibley, C.P., Brownbill, P. (2015) 'Dysregulated flow-mediated vasodilatation in the human placenta in fetal growth restriction.' The Journal of Physiology, 593(14) pp. 3077-3092.
Lattey, K., Bischof, H., Haywood, C., Brownbill, P., Jones, S. (2014) 'TRPV4; A POTENTIAL NEW TARGET TO INCREASE PLACENTAL BLOOD FLOW IN FETAL GROWTH RESTRICTED PREGNANCIES?.' HEART, 100pp. A95-A96.
Lattey, K., Bischof, H., Hayward, C., Brownbill, P., Jones, S. (2014) 'The Potential Role of Calcium Channels P2X4 and TRPV4 as Shear Stress Sensors in the Fetoplacental Endothelium.' REPRODUCTIVE SCIENCES, 21(3) pp. 91A-91A.
Abumaree, M.H., Brownbill, P., Burton, G., Castillo, C., Chamley, L., Croy, B.A., Drewlo, S., Dunk, C., Girard, S., Hansson, S., Jones, S., Jurisicova, A., Lewis, R., Letarte, M., Parast, M., Pehrson, C., Rapolee, D., Schneider, H., Tannetta, D., Varmuza, S., Wadsack, C., Wallace, A.E., Zeniro, C., Lash, G.E. (2014) 'IFPA Meeting 2013 Workshop Report III: Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta.' Placenta,
Abumaree, M.H., Brownbill, P., Burton, G., Castillo, C., Chamley, L., Croy, B.A., Drewlo, S., Dunk, C., Girard, S., Hansson, S., Jones, S., Jurisicova, A., Lewis, R., Letarte, M., Parast, M., Pehrson, C., Rappolee, D., Schneider, H., Tannetta, D., Varmuza, S., Wadsack, C., Wallace, A.E., Zenerino, C., Lash, G.E. (2014) 'IFPA Meeting 2013 Workshop Report III: Maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta.' Placenta, 35(SUPPL)
Jones, S., Evans, R.J., Mahaut-Smith, M.P. (2014) 'Ca2+ influx through P2X1 receptors amplifies P2Y1 receptor-evoked Ca2+ signaling and ADP-evoked platelet aggregation.' Molecular Pharmacology, 86(3) pp. 243-251.
Lalo, U., Jones, S., Roberts, J.A., Mahaut-Smith, M.P., Evans, R.J. (2012) 'Heat shock protein 90 inhibitors reduce trafficking of ATP-gated P2X1 receptors and human platelet responsiveness.' Journal of Biological Chemistry, 287(39) pp. 32747-32754.
Vaiyapuri, S., Jones, C.I., Sasikumar, P., Moraes, L.A., Munger, S.J., Wright, J.R., Ali, M.S., Sage, T., Kaiser, W.J., Tucker, K.L., Stain, C.J., Bye, A.P., Jones, S., Oviedo-Orta, E., Simon, A.M., Mahaut-Smith, M.P., Gibbins, J.M. (2012) 'Gap junctions and connexin hemichannels underpin hemostasis and thrombosis.' Circulation, 125(20) pp. 2479-2491.
Fung, C.Y.E., Jones, S., Ntrakwah, A., Naseem, K.M., Farndale, R.W., Mahaut-Smith, M.P. (2012) 'Platelet Ca2+ responses coupled to glycoprotein VI and Toll-like receptors persist in the presence of endothelial-derived inhibitors: Roles for secondary activation of P2X1 receptors and release from intracellular Ca 2+ stores.' Blood, 119(15) pp. 3613-3621.
Mahaut-Smith, M.P., Jones, S., Evans, R.J. (2011) 'The P2X1 receptor and platelet function.' Purinergic Signalling, 7(3) pp. 341-356.
Jones, S., Moore, C., Emerson, M., Leon, C., Gachet, C., Evans, R., Mahaut-Smith, M. (2011) 'Crosstalk between P2X1 and P2Y1 receptors stimulates synergistic calcium responses and promotes adp-mediated platelet aggregation.' JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 9pp. 317-318.
Jones, S., Evans, R.J., Mahaut-Smith, M.P. (2011) 'Extracellular Ca2+ modulates ADP-evoked aggregation through altered agonist degradation: Implications for conditions used to study P2Y receptor activation.' British Journal of Haematology, 153(1) pp. 83-91.
Jones, S., Solomon, A., Sanz-Rosa, D., Moore, C., Holbrook, L., Cartwright, E.J., Neyses, L., Emerson, M. (2010) 'The plasma membrane calcium ATPase modulates calcium homeostasis, intracellular signaling events and function in platelets.' JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 8(12) pp. 2766-2774.
Solomon, A., Jones, S., Sanz-Rosa, D., Holbrook, L.M., Moore, C., Neyses, L., Emerson, M. (2010) 'The Plasma Membrane Calcium ATPase Regulates Calcium Homeostasis, Function and Negative Signalling Events in Platelets.' CIRCULATION, 122(21)
McCloskey, C., Jones, S., Amisten, S., Snowden, R.T., Kaczmarek, L.K., Erlinge, D., Goodall, A.H., Forsythe, I.D., Mahaut-Smith, M.P. (2010) 'Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: Roles in membrane potential, Ca2+ signalling and platelet count.' Journal of Physiology, 588(9) pp. 1399-1406.
Jones, S., Evans, R.J., Mahaut-Smith, M.P. (2010) 'Enhancement of ADP-evoked platelet aggregation at low extracellular Ca2+ concentrations results from reduced ectonucleotidase activity.' PURINERGIC SIGNALLING, 6(1) pp. 131-132.
Tymvios, C., Moore, C., Jones, S., Solomon, A., Sanz-Rosa, D., Emerson, M. (2009) 'Platelet aggregation responses are critically regulated in vivo by endogenous nitric oxide but not by endothelial nitric oxide synthase.' British Journal of Pharmacology, 158(7) pp. 1735-1742.
Tucker, K.L., Sage, T., Stevens, J.M., Jordan, P.A., Jones, S., Barrett, N.E., St-Arnaud, R., Frampton, J., Dedhar, S., Gibbins, J.M. (2008) 'A dual role for integrin-linked kinase in platelets: Regulating integrin function and ά-granule secretion.' Blood, 112(12) pp. 4523-4531.
Barrett, N.E., Holbrook, L., Jones, S., Kaiser, W.J., Moraes, L.A., Rana, R., Sage, T., Stanley, R.G., Tucker, K.L., Wright, B., Gibbins, J.M. (2008) 'Future innovations in anti-platelet therapies.' British Journal of Pharmacology, 154(5) pp. 918-939.
Jones, S., Gibbins, J.M. (2008) 'The neurokinin 1 receptor: a potential new target for anti-platelet therapy?.' Current Opinion in Pharmacology, 8(2) pp. 114-119.
Jones, S., Tucker, K.L., Sage, T., Kaiser, W.J., Barrett, N.E., Lowry, P.J., Zimmer, A., Hunt, S.P., Emerson, M., Gibbins, J.M. (2008) 'Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation.' Blood, 111(2) pp. 605-612.
Tymvios, C., Jones, S., Moore, C., Pitchford, S.C., Page, C.P., Emerson, M. (2008) 'Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse.' Thrombosis and Haemostasis, 99(2) pp. 435-440.
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Conference papers
Bye, A., Kriek, N., Sage, T., Mitchell, J., Donaghy, D., Gibbins, J., Unsworth, A. (2019) 'Novel anti-platelet properties of dietary cucurbitacins.' In The Platelet Society Meeting. Jesus College, Cambridge, 12/9/2019 - 13/9/2019.
Binsaleh, N., Wigley, C., Whitehead, K., Moreno-Martinez, D., Daniels, S., Jones, S., van Rensburg, M., Pilkington, L., Barker, D., Dempsey-Hibbert, N. (2017) 'Novel thienopyridines as potent platelet inhibitors: future treatments for platelet hyperactivity disorders?.' In 22nd Congress of the European-Hematology-Association. 102. Madrid, Spain, 22/6/2017 - 25/6/2017. Ferrata Storti Foundation, pp. 125-125.
Stratta, E., Palin, V., Sibley, C., Brownbill, P., Bischof, H., Jones, S., Jones, R. (2014) 'GLUCOCORTICOIDS INHIBIT ANGIOGENESIS AND DYSREGULATE ANGIOGENIC FACTORS IN THE HUMAN PLACENTA.' In International-Federation-of-Placenta-Associations (IFPA)/EPG Meeting. 35. Paris, FRANCE, 9/9/2014 - 12/9/2014. W B SAUNDERS CO LTD, pp. A16-A16.
Jones, S., Bischof, H., Johnstone, E., Lang, I., Desoye, G., Greenwood, S., Wareing, M., Sibley, C., Brownbill, P. (2013) 'ELEVATED SHEAR STRESS IN FETAL GROWTH RESTRICTION RESULTS IN A SUSTAINED INCREASE IN ENDOTHELIAL EXPRESSION AND ACTIVATION OF ENOS AND INOS IN THE FETOPLACENTAL VASCULATURE.' In Meeting of the International-Federation-of-Placenta-Associations (IFPA). 34. Whistler, CANADA, 11/9/2013 - 14/9/2013. W B SAUNDERS CO LTD, pp. A64-A64.
Jones, S., Bischof, H., Johnstone, E., Greenwood, S., Wareing, M., Sibley, C., Brownbill, P. (2013) 'ENDOTHELIAL DYSFUNCTION OF THE FETOPLACENTAL CIRCULATION CONTRIBUTES TO THE INCREASED VASCULAR RESISTANCE OBSERVED IN FETAL GROWTH RESTRICTION.' In Meeting of the International-Federation-of-Placenta-Associations (IFPA). 34. Whistler, CANADA, 11/9/2013 - 14/9/2013. W B SAUNDERS CO LTD, pp. A22-A22.
Jones, S., Bischof, H., Johnstone, E., Greenwood, S., Wareing, M., Sibley, C., Brownbill, P. (2013) 'FETAL INFLOW HYDROSTATIC PRESSURE MEASUREMENTS IN THE EX-VIVO PERFUSED PLACENTA CORRELATE WITH UMBILICAL ARTERY DOPPLER RI AND PI VALUES.' In Annual Meeting of the International-Federation-of-Placenta-Associations (IFPA). 34. Whistler, CANADA, 11/9/2013 - 14/9/2013. W B SAUNDERS CO LTD, pp. A64-A64.
Jones, S., Kaiser, W.J., Tucker, K.L., Sage, T., Barrett, N.E., Lowry, P.J., Zimmer, A., Hunt, S.P., Emerson, M., Gibbins, J.M. (2008) 'A Role for Peripheral Tachykinins and the Neurokinin 1 Receptor in the Regulation of Platelet Thrombus Formation.' In 25th Conference of the European-Society-for-Microcirculation. Budapest, HUNGARY, 26/8/2008 - 29/8/2008. Koller, A. (ed.) MEDIMOND S R L, pp. 43-46.
Tucker, K.L., Stevens, J.M., Jordan, P.A., Sage, T., Jones, S., Barrett, N.E., St-Arnaud, R., Frampton, J., Dedhar, S., Gibbins, J.M. (2007) 'Integrin linked kinase is important in platelet signalling and function.' In 49th Annual Meeting of the American-Society-of-Hematology. 110. Atlanta, GA, 8/12/2007 - 11/12/2007. AMER SOC HEMATOLOGY, pp. 130A-130A.
Jones, S., Graham, G., Gibbins, J.M. (2005) 'The role of peripheral tachykinins in platelet function.' In BSCR Spring Meeting 2005. 91. Univ Leicester, Leicester, ENGLAND, 21/4/2005 - 22/4/2005. B M J PUBLISHING GROUP,