Dr Nasser Al-Shanti

Academic and professional qualifications

PhD In Molecular Immunology, Univetsity of Brtisol, 2002, UK

Fellowship of the Institute of Biomedical Science (FIBMS)

PgCAP, Manchester Metropolitan University, 2012

BSc, in Biomedical Science, Al-Quds University, Palestine

Previous employment

Post-Doc at Immunology and Microbiology department, University of Bristol, 2002-2005

Why study Skeletal muscle Stem cells: ageing and regeneration ?

Postgraduate supervision (completed/in progress)

• I have supervised 12  PhD students to completion (Two as Director of the Study)
• I have supervised 1MSc by research
• 1 PhD student in 2nd year
•  2 PhD student in 1st year

External examiner roles

Reviewer:
Expert reviewer for journals: European Journal of Applied Physiology, Experimental Physiology, BMC Cell Biology, BMC Musculoskeletal Disorders, Regulatory Peptides Physiological Genomics, Journal of Cellular Physiology, Pediatric Research

External collaborations :
Bristol University (Bristol Heart Institute)
Manchester University (Cardiovascular research)
Manchester University (Wythenshawe hospital)
Southampton University (MRC Lifecourse Epidemiology Unit)

External Examiner for PhD

Expert Reviewer for UK Research Council

Research expertise

I started my career as an immunologist looking at molecular mechanisms regulating immune cells proliferation and differentiation. After 3 years, I moved to a permanent position at MMU (Healthcare Science Research Institute) working on muscle stem cells aging and regeneration. As immunologist that sparked my interest in muscle stem cells regeneration and immune system interaction. I started my lab about 10 years ago, and have worked broadly on muscle stem cell regeneration and how that changes with age. I have started using an immune system secretion to promote muscle stem cell regeneration. My research group have established a novel line of research studying the cross-talk between the immune system and skeletal muscle stem cells ageing. More specifically, we are examining how the immune system secretions modulate muscle stem cells niche and regulate muscle stem cell regeneration, and what goes wrong during the ageing process to eventually lead to weakness. To enable us to investigate such interactions, I have developed a novel culture model to enable me to examine the effect of immune system on muscle regeneration. Recently, we developed a novel functional nerve-muscle co-culture platform to study neuromuscular junctions formation in ageing and diseases. This group has expanded in the past three years to contain several MSc students and 4 PhD students at different stages of their study. The work that I lead forms the basis of my teaching at MMU, but of course it has also led to high impact scientific 27 publications and presentations

Publications

• Featured Works

  S. Al-Dabbagh, J. McPhee, M. Piasecki, C. Stewart, N. Al-Shanti (2019). Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly. Journals of Gerontology, Series A. 74(9), pp.1375-1385.

  M. Lyon, N. Al-Shanti, AP. Lightfoot, RG. Cooper (2018). O42 The antioxidant EUK-134 mitigates ER stress-induced mitochondrial dysfunction in human skeletal muscle cells. In: Rheumatology. Liverpool, ENGLAND, 1/5/2018.

  J. Coulson, L. Bagley, Y. Barnouin, S. Bradburn, G. Butler-Browne, et al. H. Gapeyeva, JY. Hogrel, T. Maden-Wilkinson, AB. Maier, C. Meskers, C. Murgatroyd, M. Narici, M. Pääsuke, L. Sassano, S. Sipilä, N. AL-Shanti, L. Stenroth, DA. Jones, JS. McPhee. (2017). Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults. Osteoporosis International. 28(9), pp.2683-2689.

  A. Saini, AP. Sharples, N. Al-Shanti, CE. Stewart (2017). Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation. Biogerontology. 18(1), pp.109-129.

  J. Saini, JS. McPhee, S. Al-Dabbagh, CE. Stewart, N. Al-Shanti (2016). Regenerative function of immune system: Modulation of muscle stem cells. Ageing Res Rev. 27, pp.67-76.

  HP. Patel, N. Al-Shanti, LC. Davies, SJ. Barton, MD. Grounds, et al. RL. Tellam, CE. Stewart, C. Cooper, AA. Sayer. (2014). Lean mass, muscle strength and gene expression in community dwelling older men: findings from the Hertfordshire Sarcopenia Study (HSS). Calcif Tissue Int. 95(4), pp.308-316.

  N. Al-Shanti, P. Durcan, S. Al-Dabbagh, GA. Dimchev, CE. Stewart (2014). Activated lymphocytes secretome inhibits differentiation and induces proliferation of C2C12 myoblasts. Cellular Physiology and Biochemistry. 33(1), pp.117-128.

• Journal articles

  S. Al-Dabbagh, J. McPhee, M. Piasecki, C. Stewart, N. Al-Shanti (2019). Soluble factors released from activated T-lymphocytes regulate C2C12 myoblast proliferation and cellular signalling, but effects are blunted in the elderly. Journals of Gerontology, Series A. 74(9), pp.1375-1385.

  J. Coulson, L. Bagley, Y. Barnouin, S. Bradburn, G. Butler-Browne, et al. H. Gapeyeva, JY. Hogrel, T. Maden-Wilkinson, AB. Maier, C. Meskers, C. Murgatroyd, M. Narici, M. Pääsuke, L. Sassano, S. Sipilä, N. AL-Shanti, L. Stenroth, DA. Jones, JS. McPhee. (2017). Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults. Osteoporosis International. 28(9), pp.2683-2689.

  A. Saini, AP. Sharples, N. Al-Shanti, CE. Stewart (2017). Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation. Biogerontology. 18(1), pp.109-129.

  J. Saini, JS. McPhee, S. Al-Dabbagh, CE. Stewart, N. Al-Shanti (2016). Regenerative function of immune system: Modulation of muscle stem cells. Ageing Res Rev. 27, pp.67-76.

  HP. Patel, N. Al-Shanti, LC. Davies, SJ. Barton, MD. Grounds, et al. RL. Tellam, CE. Stewart, C. Cooper, AA. Sayer. (2014). Lean mass, muscle strength and gene expression in community dwelling older men: findings from the Hertfordshire Sarcopenia Study (HSS). Calcif Tissue Int. 95(4), pp.308-316.

  N. Al-Shanti, P. Durcan, S. Al-Dabbagh, GA. Dimchev, CE. Stewart (2014). Activated lymphocytes secretome inhibits differentiation and induces proliferation of C2C12 myoblasts. Cellular Physiology and Biochemistry. 33(1), pp.117-128.

  PJ. Durcan, N. Al-Shanti, CE. Stewart (2013). Identification and characterization of novel Kirrel isoform during myogenesis. Physiological Reports. 1(3),

  AP. Sharples, N. Al-Shanti, DC. Hughes, MP. Lewis, CE. Stewart (2013). The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy. Growth Horm IGF Res. 23(3), pp.53-61.

  AP. Sharples, N. Al-Shanti, DC. Hughes, MP. Lewis, CE. Stewart (2013). The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy. Growth Hormone and IGF Research. 23(3), pp.53-61.

  GA. Dimchev, N. Al-Shanti, CE. Stewart (2013). Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways. J Muscle Res Cell Motil. 34(2), pp.125-136.

  T. Okoro, C. Stewart, N. Al-Shanti, A. Lemmey, P. Maddison, et al. JG. Andrew. (2013). Does muscle inflammation influence recovery of muscle strength and function in patients undergoing total hip replacement?. The Lancet. 381, pp.S82-S82.

  N. Al-Shanti, CE. Stewart (2012). Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3. J Cell Biochem. 113(3), pp.923-933.

  A. Saini, N. Al-Shanti, AP. Sharples, CE. Stewart (2012). Sirtuin 1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol. Exp Physiol. 97(3), pp.400-418.

  AP. Sharples, N. Al-Shanti, MP. Lewis, CE. Stewart (2011). Reduction of myoblast differentiation following multiple population doublings in mouse C2 C12 cells: a model to investigate ageing?. J Cell Biochem. 112(12), pp.3773-3785.

  HP. Patel, N. Al-Shanti, SJ. Barton, CE. Stewart, MD. Grounds, et al. RL. Tellam, C. Cooper, AA. Sayer. (2011). Developmental Influences on Skeletal Muscle Gene Expression in Older Men: Findings from the Hertfordshire Sarcopenia Study. JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE. 2, pp.S130-S130.

  N. Al-Shanti, SH. Faulkner, A. Saini, I. Loram, CE. Stewart (2011). A semi-automated programme for tracking myoblast migration following mechanical damage: Manipulation by chemical inhibitors. Cellular Physiology and Biochemistry. 27(6), pp.625-636.

  AP. Sharples, N. Al-Shanti, CE. Stewart (2010). C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: relevance to disease and ageing?. J Cell Physiol. 225(1), pp.240-250.

  A. Saini, N. Al-Shanti, C. Stewart (2010). C2 skeletal myoblast survival, death, proliferation and differentiation: regulation by Adra1d. Cell Physiol Biochem. 25(2-3), pp.253-262.

  N. Al-Shanti, CE. Stewart (2009). Ca2+/calmodulin-dependent transcriptional pathways: potential mediators of skeletal muscle growth and development. Biol Rev Camb Philos Soc. 84(4), pp.637-652.

  A. Saini, S. Faulkner, N. Al-Shanti, C. Stewart (2009). Powerful signals for weak muscles. Ageing Res Rev. 8(4), pp.251-267.

  N. Al-Shanti, A. Saini, CE. Stewart (2009). Two-Step versus One-Step RNA-to-CT 2-Step and One-Step RNA-to-CT 1-Step: validity, sensitivity, and efficiency. J Biomol Tech. 20(3), pp.172-179.

  A. Saini, N. Al-Shanti, SH. Faulkner, CE. Stewart (2008). Pro- and anti-apoptotic roles for IGF-I in TNF-α-induced apoptosis: A MAP kinase mediated mechanism. Growth Factors. 26(5), pp.239-253.

  N. Al-Shanti, CE. Stewart (2008). PD98059 enhances C2 myoblast differentiation through p38 MAPK activation: a novel role for PD98059. J Endocrinol. 198(1), pp.243-252.

  N. Al-Shanti, A. Saini, SH. Faulkner, CE. Stewart (2008). Beneficial synergistic interactions of TNF-α and IL-6 in C2 skeletal myoblasts - Potential cross-talk with IGF system. Growth Factors. 26(2), pp.61-73.

  A. Saini, N. Al-Shanti, CEH. Stewart (2007). Waste management - Cytokines, growth factors and cachexia (vol 17, pg 475, 2006). CYTOKINE & GROWTH FACTOR REVIEWS. 18(3-4), pp.345-345.

  A. Saini, N. Al-Shanti, CEH. Stewart (2007). Corrigendum to "Waste management-Cytokines, growth factors and cachexia" [Cytokine Growth Factor Rev. 17 (2006) 475-486] (DOI:10.1016/j.cytogfr.2006.09.006). Cytokine and Growth Factor Reviews. 18(3-4),

  N. Al-Shanti, Z. Aldahoudi (2007). Human purified CD8+ T cells: Ex vivo expansion model to generate a maximum yield of functional cytotoxic cells. Immunol Invest. 36(1), pp.85-104.

  A. Saini, N. Al-Shanti, CE. Stewart (2006). Waste management - cytokines, growth factors and cachexia. Cytokine Growth Factor Rev. 17(6), pp.475-486.

  N. Al-Shanti, Z. Aldahoodi (2006). Inhibition of alpha nascent polypeptide associated complex protein may induce proliferation, differentiation and enhance the cytotoxic activity of human CD8+ T cells. J Clin Immunol. 26(5), pp.457-464.

  N. Al-Shanti, CG. Steward, RJ. Garland, AW. Rowbottom (2004). Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides. Immunology. 112(3), pp.397-403.

  NA. Al-Shanti, CG. Steward, RJ. Garland (2003). Optimization of functional efficacy of phosphorothioate-modified oligonucleotides in a human CD8⁺ T-cell Ex Vivo expansion model. Scandinavian Journal of Immunology. 58(4), pp.462-470.

  RJ. Garland, N. El-Shanti, SE. West, JP. Hancock, NJ. Goulden, et al. CG. Steward, AW. Rowbottom. (2002). Human CD8+ CTL recognition and in vitro lysis of herpes simplex virus-infected cells by a non-MHC restricted mechanism. Scand J Immunol. 55(1), pp.61-69.

  RJ. Garland, . El-Shanti N, A. Rowbottom (2002). Human CD8+ CTL recognition and in vitro lysis of herpes simplex virus-infected cells by a non-MHC restricted mechanism. Scand J Immunol.. 55((1)),

• Chapters in books

  W. Gilmore, M. Al Qaisi, N. Al-Shanti (2015). Flow Cytometry Enumeration of Hematopoietic and Progenitor Stem Cells: Identification and Quantification. In: Handbook of Vascular Biology Techniques. Springer Netherlands, pp.439-451.

• Conferences

  M. Lyon, N. Al-Shanti, AP. Lightfoot, RG. Cooper (2018). O42 The antioxidant EUK-134 mitigates ER stress-induced mitochondrial dysfunction in human skeletal muscle cells. In: Rheumatology. Liverpool, ENGLAND, 1/5/2018.

  N. Al-Shanti, N. Reeves (2012). Effects of moderate exercise on circulating haematopoietic stem cells. Nottingham University, UK, 3/12/2012.

  N. Al-Shanti Relationship between molecular markers of muscle inflammation and muscle strength in patients undergoing total hip replacement. London, UK, 9/2012.

  N. Al-Shanti Does muscle inflammation affect pain and function in patients with hip osteoarthritis?. London, UK;, 9/2012.

  N. Al-Shanti, M-S. Suleiman Cellular signalling in the diseased left ventricle influences cellular signalling in the “normal “right ventricle of patients with aortic stenosis or ischaemic disease. Apr 2012 , London, 4/2012.

  N. Al-Shanti Increased gene expression of antioxidant enzymes, pro-survival and apoptosis proteins in diseased ventricle of coronary heart disease patients. London, UK, 4/2012.

  N. Al-Shanti, M. Hancock, A. Venturini, C. Stewart, R. Ascione, et al. G. Angelini, M-S. Suleiman. (2012). Cellular signalling in the diseased left ventricle influences cellular signalling in the non-diseased right ventricle of patients with aortic stenosis or ischaemic disease. In: CARDIOVASCULAR RESEARCH. London, ENGLAND, 30/3/2012. pp.S23-S23.

  M. Hancock, A. Venturini, N. Al-Shanti, C. Stewart, R. Ascione, et al. G. Angelini, M-S. Suleiman. (2012). Increased expression of antioxidant enzymes, pro-survival and apoptosis genes in diseased ventricle of coronary heart disease patients. In: CARDIOVASCULAR RESEARCH. London, ENGLAND, 30/3/2012. pp.S110-S110.

  N. Al-Shanti Molecular adaptation of skeletal muscle in post-surgical osteoarthritis patients: markers of inflammation, hypertrophy, atrophy and lipid metabolism. Bruges, Belgium, 2012.

  N. Al-Shanti, A. Lemmey, (2012). Effect of muscle biopsy site on gene expression in patients undergoing total hip replacement for osteoarthritis.

  N. Al-Shanti Gene expression profiles in the diseased left ventricle influences cellular signalling in the “normal “right ventricle of patients with aortic stenosis. China, 12/2011.

  N. Al-Shanti, HP. Patel Developmental influences on skeletal muscle gene expression in older men: findings from the Hertfordshire Sarcopenia Study. Oregon, USA, 9/2011.

  N. Al-Shanti Inhibition of C2C12 myoblast differentiation by serial passaging or treatment with the phosphotyrosine phosphatase inhibitor BpV(Hopic), differentially affects the expression of Spire1, Spire2 and Formin1, Formin2 genes. Acaya (Italy), 2011.

  N. Al-Shanti, PJ. Durcan Identification and expression characterisation of novel Kirrel isoform during myogenesis. Acaya (Italy),, 2011.

  N. Al-Shanti Differential effects of eicosapentaenoic acid (EPA) and palmitate on tumour necrosis factor (TNF-α) and insulin-like growth factor (IGF1) action in murine skeletal muscle cells. Manchester, UK, 2010.

Invited papers

1. Circulating levels of dickkopf-1, osteoprotegerin and sclerostin are higher in old compared with young men and women and positively associated with whole-body bone mineral density in older adults. J. CoulsonL. BagleyY. Butler-BrowneH. PääsukeL. SassanoS. Sipilä N. Al-Shanti. StenrothD. A. JonesJ. S. McPhee. Osteoporosis International. 05 June 2017.
2. Rapid screening of the antimicrobial efficacy of Ag zeolites. L. Toshevaa, , , S. Belkhaira, M. Gackowskia, b, S. Malica, N. Al-Shantia, J. Verrana. Colloids and Surfaces B: Biointerfaces. 2 June 2017.
3. Omega-3 fatty acid EPA improves regenerative capacity of mouse skeletal muscle cells exposed to saturated fat and inflammation. Saini A, Sharples AP, Al-Shanti N, Stewart CE.Biogerontology. 2016 Nov 18. 
4. Regenerative function of immune system: Modulation of muscle stem cells. Saini J, McPhee JS, Al-Dabbagh S, Stewart CE, Al-Shanti N. Ageing Res Rev. 2016 May;27:67-76. 
5. The lymphocyte secretome from young adults enhances skeletal muscle proliferation and migration, but effects are attenuated in the secretome of older. Sarah Al-Dabbagh, Jamie S. McPhee, Christopher Murgatroyd, Gillian Butler-Browne, Claire E. Stewart & Al-Shanti N. Physiol Rep, 3 (8), 2015, e12518.
6. Objective function, lean mass and associated genetic adaptations of the operated leg following total hip arthroplasty. T. Okoro, C. Stewart, , Al-Shanti N A. Lemmey P. Maddison and J. G. AndrewJournal of Musculoskeletal Research, Vol. 18, No. 2 (2015) 1550007.
7. Lean Mass, Muscle Strength and Gene Expression in Community Dwelling Older Men: Findings from the Hertfordshire Sarcopenia Study (HSS). Patel HP,Al-Shanti N , Davies LC, Barton SJ, Grounds MD, Tellam RL, Stewart CE, Cooper C, Sayer AA. Calcif Tissue Int. 2014 Jul 24.
8. Activated Lymphocytes Secretome Inhibits Differentiation and Induces Proliferation of C2C12 Myoblasts. Al-Shanti N, Durcan P, Al-Dabbagh S, Dimchev GA, Stewart CE. Cell Physiol Biochem. 2014;33(1):117-28.
9. Identification and characterization of novel Kirrel isoform during myogenesis, PJ Durcan,Al-Shanti N, CE Stewart; Physiological Reports 1 (3); 2013
10. The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy Sharples AP., Al-Shanti N , Hughes D. C., Lewis MP,Stewart CE. Growth Hormone & IGF Research. 2013, May.
11. Phospho-tyrosine phosphatase inhibitor Bpv(Hopic) enhances C2C12 myoblast migration in vitro. Requirement of PI3K/AKT and MAPK/ERK pathways. Dimchev GA, Al-Shanti N, Stewart CE. J Muscle Res Cell Motil. 2013
12. Does muscle inflammation influence recovery of muscle strength and function in patients undergoing total hip replacement? T Okoro, C Stewart, Al-Shanti N, A Lemmey, P Maddison, JG Andrew, The Lancet 381, S82, 2013.
13. Sirt1 regulates skeletal myoblast survival and enhances differentiation in the presence of resveratrol. Saini A, Al-Shanti N, Sharples A, and Stewart C. Experimental Physiology; 2012;
14. Increased expression of antioxidant enzymes, pro-survival and apoptosis genes in diseased ventricle of coronary heart disease patients. M. Hancock, A. Venturini, Al-Shanti N, C. Stewart, R. Ascione, G. Angelini, M.-S. Suleiman (Bristol and Manchester, GB; Mestre-Venice, IT); Cardiovasc Res (2012) 93
15. Inhibitory effects of IL-6 on IGF-1 activity in skeletal myoblasts could be mediated by the activation of SOCS-3. Al-Shanti N, Stewart CE. Journal of Cellular Biochemsitry; 2012; Oct 27:10.
16. Cellular signalling in the diseased left ventricle influences cellular signalling in the non-diseased right ventricle of patients with aortic stenosis or ischaemic disease. Al-Shanti N, M. Hancock, A. Venturini, C. Stewart, R. Ascione, G. Angelini, M.-S. Suleiman (Manchester and Bristol, GB; Mestre-Venice, IT;Cardiovasc Res (2012) 93 .
17. Reduction of myoblast differentiation following multiple population doublings in mouse C(2) C(12) cells: A model to investigate ageing? Sharples AP, Al-Shanti N, Lewis MP, Stewart CE. J Cell Biochem. 2011 Aug 8.jcb.23308.
18. A semi-automated programme for tracking myoblast migration following mechanical damage: Manipulation by chemical inhibitors. Al-Shanti N, Faulkner, SH, Saini, A, Loram, I & Stewart, CE. Cell Physiol Biochem. 2011;27(6):625-36.
19. Developmental Influences on Skeletal Muscle Gene Expression in Older Men: Findings from the Hertfordshire Sarcopenia Study. Patel HP, Al-Shanti N, Barton SJ, Stewart CE, Grounds MD, Tellam RL, Cooper C, Sayer AA, Journal of developemntal Origins of Health and Disease:S130-S130 01 Sep 2011.
20. C2 skeletal myoblast survival, death, proliferation and differentiation: regulation by Adra1d. Saini A, Al-Shanti N, Stewart C. Cell Physiol Biochem. 2010; 25(2-3):253-62.
21. C2 and C2C12 murine skeletal myoblast models of atrophic and hypertrophic potential: relevance to disease and ageing? Sharples AP, Al-Shanti N, Stewart CE. J Cell Physiol. 2010 Oct;225(1):240-50.
22. Ca2+/calmodulin-dependent transcriptional pathways: potential mediators of skeletal muscle growth and development. Al-Shanti N, Stewart CE. Biol Rev Camb Philos Soc. 2009 Nov;84(4):637-52.
23. Powerful signals for weak muscles. Saini A, Faulkner S, Al-Shanti N, Stewart C. Ageing Res Rev. 2009 Oct;8(4):251-67.
24. Two-Step versus One-Step RNA-to-CT 2-Step and One-Step RNA-to-CT 1-Step: validity, sensitivity, and efficiency. Al-Shanti N, Saini A, Stewart CE. J Biomol Tech. 2009 Jul;20(3):172-9.
25. Pro- and anti-apoptotic roles for IGF-I in TNF-alpha-induced apoptosis: a MAP kinase mediated mechanism. Saini A, Al-Shanti N, Faulkner SH, Stewart CE. Growth Factors. 2008 Oct;26(5):239-.
26. PD98059 enhances C2 myoblast differentiation through p38 MAPK activation: a novel role for PD98059. Al-Shanti N, Stewart CE. J Endocrinol. 2008 Jul;198(1):243-52.
27. Beneficial synergistic interactions of TNF-alpha and IL-6 in C2 skeletal myoblasts--potential cross-talk with IGF system. Al-Shanti N, Saini A, Faulkner SH, Stewart CE. Growth Factors. 2008 ;26(2):61-73.
28. Human purified CD8+ T cells: Ex vivo expansion model to generate a maximum yield of functional cytotoxic cells. Al-Shanti N, Aldahoudi Z. Immunol Invest. 2007;36(1):85-104.
29. Waste management. Saini A, Al-Shanti N, Stewart CE. Cytokines, Growth Factors and cachexia. 2006 Dec;17(6):475-86.
30. Genomic screening of unstable plaques: the Vitamin D receptor as a new target for atherosclerosis: R. A. McDonald1, Al-Shanti N, D. Mallinson, H J. McKinnon, C J. Long, C. L. Jackson. 1Bristol Heart Institute, University of Bristol, Bristol, UK; 2Organon Laboratories Ltd, Newhouse, UK, Heart 2006;92;2-
31. Inhibition of alpha nascent polypeptide associated complex protein may induce proliferation, differentiation and enhance the cytotoxic activity of human CD8+ T cells. Al-Shanti N, Aldahoodi Z. J Clin Immunol. 2006 Sep;26(5):457-64.
32. Plaque rupture-related gene expression in fat-fed Apolipoprotein E knockout mice. Al-Shanti N, H. J. McKinnon1, C. J. Long1, D. Dunbar1, D. Mallinson1, C. L. Jackson. Bristol Heart Institute, University of Bristol, 1Organon Laboratories Ltd, Newhouse ML1 5SH, Heart 2004;90:e68
33. Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides. Al-Shanti N, Steward CG, Garland RJ, Rowbottom AW. Immunology. 2004 Jul;112(3):397-403.
34. Optimization of functional efficacy of phosphorothioate-modified oligonucleotides in a human CD8+ T-cell ex vivo expansion model. Al-Shanti N, Steward CG, Garland RJ. Scand J Immunol. 2003 Oct;58(4):462-.
35. Human CD8+ CTL recognition and in vitro lysis of herpes simplex virus-infected cells by a non-MHC restricted mechanism. Garland RJ, Al-Shanti N, West SE, Hancock JP, Goulden NJ, Steward CG, Rowbottom AW. Scand J Immunol. 2002 Jan;55(1):61-9.