DPhil (PhD) University of Oxford (2012)
MBiochem University of Oxford (2008)
Associate Fellow HEA
Good Clinical Practice (March 2017)
(2013- 2019) Post-doctoral Research Associate, University of Reading
(2012-2013) Post-doctoral Research Associate, University of Oxford
BSc Biomedical Sciences
BSc Healthcare Science
Blood Science - Haematology, Red Blood Cells
Cellular Science - Cell Signalling
Biomedical Cell Biology - Platelets in Thrombotic and Non-thrombotic Disease.
MSc Biomedical Sciences
STP Clinical Sciences
My scientific interests are in understanding the signalling molecules and pathways that regulate platelet function, thrombosis an haemostasis, and how these pathways impact both health and disease. In addition to their roles in the maintenance of thrombosis and haemostasis, platelets have been identified to have many wide-ranging roles, both in health and disease, including in inflammation, development of atherosclerosis and cancer progression. My research aims to understand the role platelets play in pathological conditions which is essential for the identification of drug targets, development of anti-platelet therapy and repurposing of drugs for the treatment of CVD and other diseases.
G. Flora, K. Sahli, P. Sasikumar, L. Holbrook, A. Stainer, et al. Non-genomic effects of the Pregnane X Receptor negatively regulate GPVI-mediated platelet signalling. Scientific Reports.
AR. Stainer, P. Sasikumar, AP. Bye, AJ. Unsworth, LM. Holbrook, et al. (2019). The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects. TH open : companion journal to thrombosis and haemostasis. 3(3), pp.e244-e258.
A. Unsworth, I. Bombik, A. Pinto-Fernandez, J. McGouran, R. Konietzny, et al. (2018). Human Platelet Protein Ubiquitylation and Changes following GPVI Activation. Thrombosis and Haemostasis. 119(01), pp.104-116.
AJ. Unsworth, AP. Bye, N. Kriek, T. Sage, AA. Osborne, et al. (2018). Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction. Platelets. pp.1-11.
P. Sasikumar, KS. AlOuda, WJ. Kaiser, LM. Holbrook, N. Kriek, et al. (2018). The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis. Journal of Thrombosis and Haemostasis (JTH). 16(5), pp.946-959.
AP. Bye, AJ. Unsworth, JM. Gibbins (2018). Screening and High-Throughput Platelet Assays. Methods in Molecular Biology. 1812, pp.81-94.
AP. Bye, Z. Ilkan, AJ. Unsworth, CI. Jones (2018). Immobilization of Nonactivated Unfixed Platelets for Real-Time Single-Cell Analysis. Methods in molecular biology (Clifton, N.J.). 1812, pp.1-11.
AP. Bye, AJ. Unsworth, MJ. Desborough, CAT. Hildyard, N. Appleby, et al. (2017). Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Adv. 1(26), pp.2610-2623.
AJ. Unsworth, AP. Bye, DS. Tannetta, MJR. Desborough, N. Kriek, et al. (2017). Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets. Arterioscler Thromb Vasc Biol. 37(8), pp.1482-1493.
AJ. Unsworth, GD. Flora, P. Sasikumar, AP. Bye, T. Sage, et al. (2017). RXR Ligands Negatively Regulate Thrombosis and Hemostasis. Arterioscler Thromb Vasc Biol. 37(5), pp.812-822.
AJ. Unsworth, N. Kriek, AP. Bye, K. Naran, T. Sage, et al. (2017). PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signaling and platelet function through up-regulation of protein kinase A activity. Journal of thrombosis and haemostasis : JTH. 15(2), pp.356-369.
LA. Moraes, AJ. Unsworth, S. Vaiyapuri, MS. Ali, P. Sasikumar, et al. (2016). Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets. Arterioscler Thromb Vasc Biol. 36(12), pp.2324-2333.
AP. Bye, AJ. Unsworth, S. Vaiyapuri, AR. Stainer, MJ. Fry, et al. (2015). Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen. Arterioscler Thromb Vasc Biol. 35(11), pp.2326-2335.
RAJ. Darby, A. Unsworth, S. Knapp, ID. Kerr, R. Callaghan (2015). Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors. Cancer Chemother Pharmacol. 76(4), pp.853-864.
S. Vaiyapuri, T. Sage, RH. Rana, MP. Schenk, MS. Ali, et al. (2015). EphB2 regulates contact-dependent and contact-independent signaling to control platelet function. Blood. 125(4), pp.720-730.
AJ. Unsworth, H. Smith, P. Gissen, SP. Watson, CJ. Pears (2011). Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+. J Biol Chem. 286(24), pp.21073-21082.
AJ. Unsworth, AP. Bye, JM. Gibbins (2017). Platelet-Derived Inhibitors of Platelet Activation. P. Gresele, NS. Kleiman, JA. Lopez, CP. Page. In: Platelets in Thrombotic and Non-Thrombotic Disorders. Springer International Publishing, pp.541-556.
A. Bye, N. Kriek, T. Sage, J. Mitchell, D. Donaghy, et al. Novel anti-platelet properties of dietary cucurbitacins. Jesus College, Cambridge, 12/9/2019.
A. Unsworth, A. Bye, T. Sage, J. Hutchinson, N. Kriek, et al. Inhibition of Platelet Activity by Pim Kinase Inhibitors. A Novel Mechanism of Regulation of Thromboxane A2 Receptor Signalling. University of Bath, 7/9/2017.
A. Unsworth, A. Bye, T. Sage, N. Kriek, J. Hutchinson, et al. Inhibition of Platelet Activity by Pim Kinase Inhibitors. A Novel Mechanism of Regulation of Thromboxane A2 Receptor Signalling. Renaissance Tuscany Il Ciocco Via Giovanni Pascoli Lucca (Barga), IT, 26/2/2017.
A. Unsworth, P. Sasikumar, A. Bye, N. Kriek, T. Sageq, et al. Nuclear receptor dependent formation of COATED platelets, inhibits activation to platelet agonists. Toronto, 20/6/2015.
A. Unsworth, N. Kriek, T. Sage, J. Gibbins Non-genomic effects of nuclear receptors: Different mechanisms of regulation of outside–in signalling in platelets. Le Bischenberg, France, 25/9/2014.
A. Unsworth, N. Kriek, T. Sage, L. Moraes, B. Gibbins Non-genomic effects of nuclear receptors: Different mechanisms of regulation of outside–in signalling in platelets. Waterville Valley, NH, US, 27/7/2014.
2019 Chair for the Gordon Research Seminar on the Cell Biology of Megakaryocytes and Platelets
Peer Review for Journal of Thrombosis and Haemostasis, Arteriosclerosis, Thrombosis and Vascular Biology, Thrombosis and Haemostasis, Scientific Reports, Platelets.
Fellow - Institute of Biomedical Science
Associate Fellow - Higher Education Academy
Member of the Platelet Society
Member of the Biochemical Society
Member of The British Society for Cardiovascular Research