DPhil (PhD) University of Oxford (2012)
MBiochem University of Oxford (2008)
PGCertTLHE (2020)
Fellow HEA
Good Clinical Practice (March 2017)
(2013- 2019) Post-doctoral Research Associate, University of Reading
(2012-2013) Post-doctoral Research Associate, University of Oxford
BSc Biomedical Sciences
BSc Healthcare Science
Blood Science - Haematology, Haemostasis and Thrombosis
Biomedical Cell Biology - Platelets in Thrombotic and Non-thrombotic Disease.
Cardiovascular Science - Thrombosis and Therapeutics
MSc Biomedical Sciences
STP Clinical Sciences - Haematology and Transfusion
Clinical Haematology
Haemostasis
Supervision of MRes and PhD students.
PhD Examination - University of Bristol 2020
PhD Examination - University of Birmingham 2020
My scientific interests are in understanding the signalling molecules and pathways that regulate platelet function, thrombosis an haemostasis, and how these pathways impact both health and disease. In addition to their roles in the maintenance of thrombosis and haemostasis, platelets have been identified to have many wide-ranging roles, both in health and disease, including in inflammation, development of atherosclerosis and cancer progression. My research aims to understand the role platelets play in pathological conditions which is essential for the identification of drug targets, development of anti-platelet therapy and repurposing of drugs for the treatment of CVD and other diseases.
Internal
Dr Sarah Jones
Dr Ria Weston
Dr Stephen White
Dr Mark McLauglin
Dr Andrew Lewis
Dr Marilena Crescente
External
Professor Khalid Naseem, University of Leeds
Professor Stuart Mundell, University of Bristol
Dr Cedric Ghevaert, University of Cambridge
Professor Jon Gibbins, University of Reading
Dr Steve Thomas, University of Birmingham
Dr Kellie Machlus, Harvard Medical School
Professor Stuart Allan, University of Manchester
Dr Lynda Harris, University of Manchester
JL. Mitchell, JL. Dunster, N. Kriek, AJ. Unsworth, T. Sage, et al. YMM. Mohammed, I. De Simone, KA. Taylor, AP. Bye, G. Ólafsson, M. Brunton, S. Mark, LD. Dymott, A. Whyte, N. Ruparelia, C. Mckenna, JM. Gibbins, CI. Jones. (2023). The rate of platelet activation determines thrombus size and structure at arterial shear. Journal of thrombosis and haemostasis : JTH. 21(8), pp.2248-2259.
SJ. Kuravi, NS. Ahmed, KA. Taylor, EM. Capes, A. Bye, et al. AJ. Unsworth, JM. Gibbins, N. Pugh. (2023). Delineating Zinc Influx Mechanisms during Platelet Activation. International journal of molecular sciences. 24(14),
JL. Mitchell, G. Little, AP. Bye, RS. Gaspar, AJ. Unsworth, et al. N. Kriek, T. Sage, A. Stainer, I. Sangowawa, GB. Morrow, RN. Bastos, S. Shapiro, MJR. Desborough, N. Curry, JM. Gibbins, CS. Whyte, NJ. Mutch, CI. Jones. (2023). Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability. Research and practice in thrombosis and haemostasis. 7(5),
S. Nock, E. Karim, AJ. Unsworth (2023). Pim Kinases: Important Regulators of Cardiovascular Disease. International journal of molecular sciences. 24(14),
A. Drysdale, AJ. Unsworth, SJ. White, S. Jones (2023). The Contribution of Vascular Proteoglycans to Atherothrombosis: Clinical Implications. International journal of molecular sciences. 24(14),
MG. Posner, NC. Dempsey, AJ. Unsworth (2023). The Benefits of Using Case Study Focussed, Problem Based Learning Approaches to Unit Design for Biomedical Science Students. British journal of biomedical science. 80,
S. Albayati, N. Li, AJ. Unsworth, E. Liverani (2022). Platelet-lymphocyte co-culture serves as an ex vivo platform of dynamic heterotypic cross-talk. Journal of cell communication and signaling. 16(4), pp.661-675.
N. Kriek, SH. Nock, T. Sage, B. Khalifa, AP. Bye, et al. JL. Mitchell, S. Thomson, MG. McLaughlin, S. Jones, JM. Gibbins, AJ. Unsworth. (2022). Cucurbitacins Elicit Anti-Platelet Activity via Perturbation of the Cytoskeleton and Integrin Function. Thrombosis and haemostasis. 122(7), pp.1115-1129.
S. Wang, S. Hu, X. Luo, X. Bao, J. Li, et al. M. Liu, Y. Lv, C. Zhao, M. Zeng, X. Chen, A. Unsworth, S. Jones, TW. Johnson, SJ. White, H. Jia, B. Yu. (2022). Prevalence and prognostic significance of DNMT3A- and TET2- clonal haematopoiesis-driver mutations in patients presenting with ST-segment elevation myocardial infarction. EBioMedicine. 78,
AJ. Unsworth, MG. Posner (2022). Case Study: Using H5P to design and deliver interactive laboratory practicals. Essays in biochemistry. 66(1), pp.19-27.
JL. Dunster, AP. Bye, N. Kriek, T. Sage, JL. Mitchell, et al. C. Kempster, J. Batista, H. McKinney, P. Thomas, CI. Jones, K. Downes, AJ. Unsworth, JM. Gibbins. (2021). Multiparameter phenotyping of platelet reactivity for stratification of human cohorts. Blood advances. 5(20), pp.4017-4030.
AJ. Unsworth, AP. Bye, T. Sage, RS. Gaspar, N. Eaton, et al. C. Drew, A. Stainer, N. Kriek, PJ. Volberding, JL. Hutchinson, R. Riley, S. Jones, SJ. Mundell, W. Cui, H. Falet, JM. Gibbins. (2021). Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling. Haematologica. 106(7), pp.1968-1978.
KA. Sahli, GD. Flora, P. Sasikumar, AH. Maghrabi, L-M. Holbrook, et al. SK. AlOuda, A. Elgheznawy, T. Sage, AR. Stainer, R. Adiyaman, M. AboHassan, M. Crescente, N. Kriek, S. Vaiyapuri, AP. Bye, AJ. Unsworth, CI. Jones, LJ. McGuffin, JM. Gibbins. (2021). Structural, functional, and mechanistic insights uncover the fundamental role of orphan connexin-62 in platelets. Blood. 137(6), pp.830-843.
RS. Gaspar, AJ. Unsworth, A. Al-Dibouni, AP. Bye, T. Sage, et al. M. Stewart, S. Wells, RD. Cox, JM. Gibbins, D. Sellayah, C. E Hughes. (2021). Maternal and offspring high-fat diet leads to platelet hyperactivation in male mice offspring. Scientific reports. 11(1),
JL. Dunster, AJ. Unsworth, AP. Bye, EJ. Haining, MA. Sowa, et al. Y. Di, T. Sage, C. Pallini, JA. Pike, AT. Hardy, B. Nieswandt, Á. García, SP. Watson, NS. Poulter, JM. Gibbins, AY. Pollitt. (2020). Interspecies differences in protein expression do not impact the spatiotemporal regulation of glycoprotein VI mediated activation. Journal of thrombosis and haemostasis : JTH. 18(2), pp.485-496.
GD. Flora, KA. Sahli, P. Sasikumar, L-M. Holbrook, AR. Stainer, et al. SK. AlOuda, M. Crescente, T. Sage, AJ. Unsworth, JM. Gibbins. (2019). Non-genomic effects of the Pregnane X Receptor negatively regulate platelet functions, thrombosis and haemostasis. Scientific reports. 9(1),
AR. Stainer, P. Sasikumar, AP. Bye, AJ. Unsworth, LM. Holbrook, et al. M. Tindall, JA. Lovegrove, JM. Gibbins. (2019). The Metabolites of the Dietary Flavonoid Quercetin Possess Potent Antithrombotic Activity, and Interact with Aspirin to Enhance Antiplatelet Effects. TH open : companion journal to thrombosis and haemostasis. 3(3), pp.e244-e258.
AJ. Unsworth, I. Bombik, A. Pinto-Fernandez, JF. McGouran, R. Konietzny, et al. RP. Zahedi, SP. Watson, BM. Kessler, CJ. Pears. (2019). Human Platelet Protein Ubiquitylation and Changes following GPVI Activation. Thrombosis and haemostasis. 119(1), pp.104-116.
AJ. Unsworth, AP. Bye, N. Kriek, T. Sage, AA. Osborne, et al. D. Donaghy, JM. Gibbins. (2019). Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction. Platelets. 30(6), pp.762-772.
(2018). Bye AP, Unsworth AJ, Desborough MJ, et al. Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood Adv. 2017;1(26):2610-2623. Blood advances. 2(23),
P. Sasikumar, KS. AlOuda, WJ. Kaiser, LM. Holbrook, N. Kriek, et al. AJ. Unsworth, AP. Bye, T. Sage, R. Ushioda, K. Nagata, RW. Farndale, JM. Gibbins. (2018). The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis. Journal of thrombosis and haemostasis : JTH. 16(5), pp.946-959.
AJ. Unsworth, GD. Flora, JM. Gibbins (2018). Non-genomic effects of nuclear receptors: insights from the anucleate platelet. Cardiovascular research. 114(5), pp.645-655.
AP. Bye, AJ. Unsworth, MJ. Desborough, CAT. Hildyard, N. Appleby, et al. D. Bruce, N. Kriek, SH. Nock, T. Sage, CE. Hughes, JM. Gibbins. (2017). Severe platelet dysfunction in NHL patients receiving ibrutinib is absent in patients receiving acalabrutinib. Blood advances. 1(26), pp.2610-2623.
AJ. Unsworth, AP. Bye, DS. Tannetta, MJR. Desborough, N. Kriek, et al. T. Sage, HE. Allan, M. Crescente, P. Yaqoob, TD. Warner, CI. Jones, JM. Gibbins. (2017). Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets. Arteriosclerosis, thrombosis, and vascular biology. 37(8), pp.1482-1493.
AJ. Unsworth, GD. Flora, P. Sasikumar, AP. Bye, T. Sage, et al. N. Kriek, M. Crescente, JM. Gibbins. (2017). RXR Ligands Negatively Regulate Thrombosis and Hemostasis. Arteriosclerosis, thrombosis, and vascular biology. 37(5), pp.812-822.
AJ. Unsworth, N. Kriek, AP. Bye, K. Naran, T. Sage, et al. GD. Flora, JM. Gibbins. (2017). PPARγ agonists negatively regulate αIIbβ3 integrin outside-in signaling and platelet function through up-regulation of protein kinase A activity. Journal of thrombosis and haemostasis : JTH. 15(2), pp.356-369.
LA. Moraes, AJ. Unsworth, S. Vaiyapuri, MS. Ali, P. Sasikumar, et al. T. Sage, GD. Flora, AP. Bye, N. Kriek, E. Dorchies, O. Molendi-Coste, D. Dombrowicz, B. Staels, D. Bishop-Bailey, JM. Gibbins. (2016). Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets. Arteriosclerosis, thrombosis, and vascular biology. 36(12), pp.2324-2333.
AP. Bye, AJ. Unsworth, JM. Gibbins (2016). Platelet signaling: a complex interplay between inhibitory and activatory networks. Journal of thrombosis and haemostasis : JTH. 14(5), pp.918-930.
AP. Bye, AJ. Unsworth, S. Vaiyapuri, AR. Stainer, MJ. Fry, et al. JM. Gibbins. (2015). Ibrutinib Inhibits Platelet Integrin αIIbβ3 Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen. Arteriosclerosis, thrombosis, and vascular biology. 35(11), pp.2326-2335.
RAJ. Darby, A. Unsworth, S. Knapp, ID. Kerr, R. Callaghan (2015). Overcoming ABCG2-mediated drug resistance with imidazo-[1,2-b]-pyridazine-based Pim1 kinase inhibitors. Cancer chemotherapy and pharmacology. 76(4), pp.853-864.
S. Vaiyapuri, H. Roweth, MS. Ali, AJ. Unsworth, AR. Stainer, et al. GD. Flora, M. Crescente, CI. Jones, LA. Moraes, JM. Gibbins. (2015). Pharmacological actions of nobiletin in the modulation of platelet function. British journal of pharmacology. 172(16), pp.4133-4145.
S. Vaiyapuri, T. Sage, RH. Rana, MP. Schenk, MS. Ali, et al. AJ. Unsworth, CI. Jones, AR. Stainer, N. Kriek, LA. Moraes, JM. Gibbins. (2015). EphB2 regulates contact-dependent and contact-independent signaling to control platelet function. Blood. 125(4), pp.720-730.
AJ. Unsworth, BA. Finney, L. Navarro-Nunez, S. Severin, SP. Watson, et al. CJ. Pears. (2013). Corrigendum. Journal of Thrombosis and Haemostasis. 11(1), pp.217-217.
AJ. Unsworth, BA. Finney, L. Navarro-Nunez, S. Severin, SP. Watson, et al. CJ. Pears. (2012). Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis. Journal of thrombosis and haemostasis : JTH. 10(9), pp.1887-1894.
AJ. Unsworth, H. Smith, P. Gissen, SP. Watson, CJ. Pears (2011). Submaximal inhibition of protein kinase C restores ADP-induced dense granule secretion in platelets in the presence of Ca2+. The Journal of biological chemistry. 286(24), pp.21073-21082.
AP. Bye, Z. Ilkan, AJ. Unsworth, CI. Jones (2018). Immobilization of Nonactivated Unfixed Platelets for Real-Time Single-Cell Analysis. pp.1-11.
AP. Bye, AJ. Unsworth, JM. Gibbins (2018). Screening and High-Throughput Platelet Assays. pp.81-94.
AJ. Unsworth, AP. Bye, JM. Gibbins (2017). Platelet-derived inhibitors of platelet activation. In: Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: an Update. pp.541-556.
A. Unsworth, A. Bye, T. Sage, J. Hutchinson, N. Kriek, et al. S. Mundell, J. Gibbins. Inhibition of Platelet Activity by Pim Kinase Inhibitors. A Novel Mechanism of Regulation of Thromboxane A2 Receptor Signalling. University of Bath, 7/9/2017.
A. Unsworth, A. Bye, T. Sage, N. Kriek, J. Hutchinson, et al. S. Mundell, J. Gibbins. Inhibition of Platelet Activity by Pim Kinase Inhibitors. A Novel Mechanism of Regulation of Thromboxane A2 Receptor Signalling. Renaissance Tuscany Il Ciocco Via Giovanni Pascoli Lucca (Barga), IT, 26/2/2017.
A. Unsworth, P. Sasikumar, A. Bye, N. Kriek, T. Sageq, et al. M. Schenk, C. Jones, J. Gibbins. Nuclear receptor dependent formation of COATED platelets, inhibits activation to platelet agonists. Toronto, 20/6/2015.
L-M. Holbrook, E. Brunt, K. Mitchell, M. Ooms, C. Galinski, et al. A. Unsworth, J. Gibbins, D. Kennedy. (2015). The identification and characterization of cinnamaldehyde analogs, as novel small molecule inhibitors of platelet-surface ERP57. In: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. pp.914-915.
A. Unsworth, N. Kriek, T. Sage, J. Gibbins Non-genomic effects of nuclear receptors: Different mechanisms of regulation of outside–in signalling in platelets. Le Bischenberg, France, 25/9/2014.
A. Unsworth, N. Kriek, T. Sage, L. Moraes, B. Gibbins Non-genomic effects of nuclear receptors: Different mechanisms of regulation of outside–in signalling in platelets. Waterville Valley, NH, US, 27/7/2014.
2019 Chair for the Gordon Research Seminar on the Cell Biology of Megakaryocytes and Platelets
2021 Platelet Society Conference
Peer Review for Journal of Thrombosis and Haemostasis, Arteriosclerosis, Thrombosis and Vascular Biology, Thrombosis and Haemostasis, Scientific Reports, Platelets and Vascular Pharmacology.
Research in my lab is funded by the British Heart Foundation
STEM ambassador
Ad hoc reviewer for The British Heart Foundation
Fellow - Higher Education Academy
Member of the Platelet Society, also Executive Committee member of the Society.
Member of the Biochemical Society
Member of The British Society for Cardiovascular Research