Chemistry
Watch our video of Dr Paul Smith, Senior Lecturer in Inorganic Chemistry, explaining the impact chemists can have on the world and why he loves the subject.
The MChem (Hons) Chemistry is an integrate…
Dr Andrew Lewis
Senior Lecturer in Chemical Biology
Chemical Biologist working to create molecular tools to answer biological questions
My profile
Biography
Originally from Swansea in Wales, Dr Andrew Lewis graduated with his PhD from the University of Cambridge in 2013 under the supervision of Professor Sir Shankar Balasubramanian. During his PhD he worked on the synthesis and biological understanding of quinone containing natural products and their use as anticancer agents. Prior to this, Andrew read Natural Sciences at St Catharine’s College, University of Cambridge completing his MSc with Professor Steven Ley working on the synthesis of novel hydrogen bond organocatalysts.
From 2013 to 2016 Andrew worked as a postdoctoral fellow at the University of Toronto with Professor Patrick Gunning working on the design and synthesis of protein-protein interaction inhibitors and using chemical biological techniques to understand their mode of action. After moving back to the UK in 2016 Andrew joined the Huber group at the Target Discovery Institute, University of Oxford where his research involved the use of chemical biology and chemoproteomic techniques to identify novel drug targets for multiple myeloma.
In October 2019 Andrew joined Manchester Metropolitan University as a lecturer in chemical biology where his group focuses on developing chemical tools to understand protein-protein interactions
Academic and professional qualifications
2008-2012 PhD - CRUK Graduate Training Programme in Medicinal Chemistry, University of Cambridge
Supervisor: Professor Sir Shankar Balasubramanian
2007-2008 MSci Chemistry, University of Cambridge
Supervisor: Professor Steve Ley
Previous employment
2016-2019 Postdoctoral Research Fellow, Target Discovery Institute, University of Oxford
Supervisor: Dr Kilian Huber
2013-2016 Postdoctoral Research Fellow, University of Toronto
Supervisor: Professor Patrick Gunning
Teaching
I teach organic chemistry and chemical biology with a focus on demonstrating to chemistry students the importance and impact of chemistry within biological resesarch
Medicinal and Pharmaceutical Chemistry
Watch our video of Dr Paul Smith, Senior Lecturer in Inorganic Chemistry, explaining the impact chemists can have on the world and why he loves the subject.
Our BSc (Hons) Medicinal and Pharmaceutica…
Supervision
Current Lab Members
Anam Khan (PhD 2021)
Charlotte Pearson (MRes 2023)
Lauren Paszczuk (MRes 2023 Joint with Dr Britten)
Keziah Cobain (MChem 2023)
Oliver Harrison (MChem 2023)
Lab Alumni
Fahmida Begum (MRes 2021-2022)
Elese Stockley (MChem 2022)
Mohamed Aden (MChem 2021)
Jenine Muganyi-Ingleton (MRes 2020-2021)
Nadia Breugelmans (Erasmus 2021)
Research outputs
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Chapters in books
Lewis, A.M., Ball, D.P., Rana, R., Park, J.S., Rosa, D., Lai, P.S., Gómez-Biagi, R.F., Gunning, P.T. (2015) 'Developing Inhibitors of STAT3: Targeting Downstream of the Kinases for Treating Disease.' Kinomics: Approaches and Applications. pp. 281-300.
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Journal articles
Fagan, V., Johansson, C., Gileadi, C., Monteiro, O., Dunford, J.E., Nibhani, R., Philpott, M., Malzahn, J., Wells, G., Farham, R., Cribbs, A., Halidi, N., Li, F., Chau, I., Greschik, H., Velupillai, S., Allali-Hassani, A., Bennett, J.M., Christott, T., Giroud, C., Lewis, A.M., Huber, K.V.M., Athanasou, N., Bountra, C., Jung, M., Schüle, R., Vedadi, M., Arrowsmith, C.H., Xiong, Y., Jin, J., Fedorov, O., Farnie, G., Brennan, P.E., Oppermann, U.C.T. (2019) 'A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function..' Journal of Medicinal Chemistry, 62(20) pp. 9008-9025.
Scheer, S., Ackloo, S., Medina, T.S., Schapira, M., Li, F., Ward, J.A., Lewis, A.M., Northrop, J.P., Richardson, P.L., Kaniskan, H.Ü., Shen, Y., Liu, J., Smil, D., McLeod, D., Zepeda-Velazquez, C.A., Luo, M., Jin, J., Barsyte-Lovejoy, D., Huber, K.V.M., De Carvalho, D.D., Vedadi, M., Zaph, C., Brown, P.J., Arrowsmith, C.H. (2019) 'A chemical biology toolbox to study protein methyltransferases and epigenetic signaling.' Nature Communications, 10(1)
Stefaniak, J., Lewis, A.M., Conole, D., Galan, S.R.G., Bataille, C.J.R., Wynne, G.M., Castaldi, M.P., Lundbäck, T., Russell, A.J., Huber, K.V.M. (2018) 'Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors..' ACS Chemical Biology, 13(10) pp. 2849-2854.
Scheer, S., Ackloo, S., Medina, T., Schapira, M., Li, F., Ward, J., Lewis, A., Northrop, J., Richardson, P., Kaniskan, Ü., Shen, Y., Liu, J., Smil, D., Luo, M., Jin, J., Barsyte-Lovejoy, D., Huber, K., De Carvalho, D., Vedadi, M., Zaph, C., Brown, P., Arrowsmith, C. (2018) 'A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling.' bioRxiv,
Ball, D.P., Lewis, A.M., Williams, D., Resetca, D., Wilson, D.J., Gunning, P.T. (2016) 'Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent..' Oncotarget, 7(15) pp. 20669-20679.
da Silva, S.R., Paiva, S.L., Bancerz, M., Geletu, M., Lewis, A.M., Chen, J., Cai, Y., Lukkarila, J.L., Li, H., Gunning, P.T. (2016) 'A selective inhibitor of the UFM1-activating enzyme, UBA5..' Bioorganic & medicinal chemistry letters, 26(18) pp. 4542-4547.
Haftchenary, S., Jouk, A.O., Aubry, I., Lewis, A.M., Landry, M., Ball, D.P., Shouksmith, A.E., Collins, C.V., Tremblay, M.L., Gunning, P.T. (2015) 'Identification of Bidentate Salicylic Acid Inhibitors of PTP1B..' ACS medicinal chemistry letters, 6(9) pp. 982-986.
Singh, M., Garg, N., Venugopal, C., Hallett, R., Tokar, T., McFarlane, N., Mahendram, S., Bakhshinyan, D., Manoranjan, B., Vora, P., Qazi, M., Arpin, C.C., Page, B., Haftchenary, S., Rosa, D.A., Lai, P.S., Gómez-Biagi, R.F., Ali, A.M., Lewis, A., Geletu, M., Murty, N.K., Hassell, J.A., Jurisica, I., Gunning, P.T., Singh, S.K. (2015) 'STAT3 pathway regulates lung-derived brain metastasis initiating cell capacity through miR-21 activation..' Oncotarget, 6(29) pp. 27461-27477.
Cumaraswamy, A.A., Lewis, A.M., Geletu, M., Todic, A., Diaz, D.B., Cheng, X.R., Brown, C.E., Laister, R.C., Muench, D., Kerman, K., Grimes, H.L., Minden, M.D., Gunning, P.T. (2014) 'Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein..' ACS medicinal chemistry letters, 5(11) pp. 1202-1206.
Page, B.D.G., Croucher, D.C., Li, Z.H., Haftchenary, S., Jimenez-Zepeda, V.H., Atkinson, J., Spagnuolo, P.A., Wong, Y.L., Colaguori, R., Lewis, A.M., Schimmer, A.D., Trudel, S., Gunning, P.T. (2013) 'Inhibiting aberrant signal transducer and activator of transcription protein activation with tetrapodal, small molecule Src homology 2 domain binders: promising agents against multiple myeloma..' Journal of medicinal chemistry, 56(18) pp. 7190-7200.