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Dr Stephen White is a molecular and cell biologist with more than 20 years’ experience. He is a Reader in Cardiovascular Pathology and Deputy Director of the Centre for Bioscience at Manchester Metropolitan University, as well as overseeing all GM work at the University. Dr White has extensive experience in vascular cell biology with 16 publications in vascular biology and imaging. His work focuses on the underlying mechanisms that cause heart attacks, predominantly the causes of endothelial erosion, which precipitate a third of acute coronary syndromes. Dr White works as part of a large multidisciplinary team including clinicians, biologists, bioinformaticians and engineers, with collaborators across the globe. In addition, he has wide-ranging experience in molecular biology, vectorology, and expression cassette design for optimising and targeting gene expression, with an additional 17 peer reviewed publications on this subject, including publications in the highest ranked cardiovascular journals. He also has significant experience in creating and optimising complex physiological cell models that mimic in vivo conditions to facilitate translational research. He has a proven track record in securing research funding, currently totalling £1.19M. Dr White has supervised a total of 6 PhD students and 2 postdoctoral scientists.
"Try not to become a man of success, but rather try to become a man of value." - Albert Einstein
"the only difference between a problem and a challenge is the way you approach the issue." - Steve White
I teach on cardiovascular disease, particularly atherosclerosis and stroke, combining science and clinical practice.
https://www.researchgate.net/profile/Stephen_White
My main research focus is the mechanisms that trigger heart attacks. I have particular expertise in endothelial and vascular biomechanics, endothelial biology and molecular biology. I work closely with clinicians and engineers to bring a multi-disicplinary approach to my research.
JE. Teasdale, GGJ. Hazell, AMG. Peachey, GB. Sala-Newby, CCT. Hindmarch, et al. TR. McKay, M. Bond, AC. Newby, SJ. White. (2017). Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells. Scientific reports. 7,
GG. Hazzell, AM. Peachey, JE. Teasdale, G. Sala-Newby, G. Angelini, et al. AC. Newby, SJ. White. (2016). PI16 is a shear stress and inflammation-regulated inhibitor of MMP2. Scientific Reports. 6,
JE. Teasdale, AC. Newby, NJ. Timpson, MR. Munafò, SJ. White (2016). Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture. Drug and Alcohol Dependence. 163, pp.256-260.
SJ. White, EM. Hayes, S. Lehoux, JY. Jeremy, AJG. Horrevoets, et al. AC. Newby. (2011). Characterization of the Differential Response of Endothelial Cells Exposed to Normal and Elevated Laminar Shear Stress. Journal of Cellular Physiology. 226(11), pp.2841-2848.
LM. Work, SA. Nicklin, SJ. White, AH. Baker (2002). Use of phage display to identify novel peptides for targeted gene therapy. Elsevier.
M. McElroy, Y. Kim, G. Niccoli, R. Vergallo, A. Langford-Smith, et al. F. Crea, F. Gijsen, T. Johnson, A. Keshmiri, SJ. White. (2021). Identification of the haemodynamic environment permissive for plaque erosion. Scientific Reports. 11,
A. Ramasamy, J. Ng, S. White, TW. Johnson, N. Foin, et al. MJA. Girard, J. Dijkstra, R. Amersey, S. Scoltock, S. Koganti, D. Jones, C. Jin, L. Räber, PW. Serruys, R. Torii, T. Crake, R. Rakhit, A. Baumbach, A. Mathur, CV. Bourantas. (2019). Efficacy and Reproducibility of Attenuation-Compensated Optical Coherence Tomography for Assessing External Elastic Membrane Border and Plaque Composition in Native and Stented Segments - An In Vivo and Histology-Based Study. Circulation Journal.
G. Suna, W. Wojakowski, M. Lynch, J. Barallobre-Barreiro, X. Yin, et al. U. Mayr, F. Baig, R. Lu, M. Fava, R. Hayward, C. Molenaar, SJ. White, T. Roleder, K. Milewski, P. Gasior, PP. Buszman, PE. Buszman, M. Jahangiri, C. Shanahan, JM. Hill, M. Mayr. (2017). Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries. Circulation. 137(2), pp.166-183.
MC. Smith, C. Hudson, S. White, T. Kimura, G. Sala-Newby, et al. A. Newby, M. Bond. (2017). Camp divergently regulates nuclear actin and myocardin-related transcription factor (MKL1) in VSMCS and ECS. Atherosclerosis. 263, pp.e77-e77.
MC. Smith, CA. Hudson, TE. Kimura, SJ. White, GB. Sala-Newby, et al. AC. Newby, M. Bond. (2017). Divergent Regulation of Actin Dynamics and Megakaryoblastic Leukemia-1 and -2 (Mkl1/2) by cAMP in Endothelial and Smooth Muscle Cells. Scientific reports. 7,
M. Gnanadesigan, AS. Hussain, S. White, S. Scoltock, A. Baumbach, et al. AFW. van der Steen, E. Regar, TW. Johnson, G. van Soest. (2017). Optical coherence tomography attenuation imaging for lipid core detection: an ex-vivo validation study. International Journal of Cardiovascular Imaging. 33(1), pp.5-11.
JE. Teasdale, GGJ. Hazell, AMG. Peachey, GB. Sala-Newby, CCT. Hindmarch, et al. TR. McKay, M. Bond, AC. Newby, SJ. White. (2017). Cigarette smoke extract profoundly suppresses TNFα-mediated proinflammatory gene expression through upregulation of ATF3 in human coronary artery endothelial cells. Scientific reports. 7,
GG. Hazzell, AM. Peachey, JE. Teasdale, G. Sala-Newby, G. Angelini, et al. AC. Newby, SJ. White. (2016). PI16 is a shear stress and inflammation-regulated inhibitor of MMP2. Scientific Reports. 6,
K. Di Gregoli, NN. Mohamad Anuar, R. Bianco, SJ. White, AC. Newby, et al. SJ. George, JL. Johnson. (2016). MicroRNA-181b Controls Atherosclerosis and Aneurysms Through Regulation of TIMP-3 and Elastin. Circulation Research. 120, pp.49-65.
JE. Teasdale, AC. Newby, NJ. Timpson, MR. Munafò, SJ. White (2016). Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture. Drug and Alcohol Dependence. 163, pp.256-260.
TE. Kimura, A. Duggirala, MC. Smith, S. White, GB. Sala-Newby, et al. AC. Newby, M. Bond. (2016). The Hippo pathway mediates inhibition of vascular smooth muscle cell proliferation by cAMP. Journal of Molecular and Cellular Cardiology. 90, pp.1-10.
S. White, G. van Soest, TW. Johnson (2014). Development of Tissue Characterization Using Optical Coherence Tomography for Defining Coronary Plaque Morphology and the Vascular Responses After Coronary Stent Implantation. Current Cardiovascular Imaging Reports. 7(12), pp.1-10.
K. Di Gregoli, N. Jenkins, R. Salter, S. White, AC. Newby, et al. JL. Johnson. (2014). MicroRNA-24 regulates macrophage behavior and retards atherosclerosis. Arterioscler Thromb Vasc Biol. 34(9), pp.1990-2000.
M. Gnanadesigan, G. van Soest, S. White, S. Scoltock, GJ. Ughi, et al. A. Baumbach, AF. van der Steen, E. Regar, TW. Johnson. (2014). Effect of temperature and fixation on the optical properties of atherosclerotic tissue: a validation study of an ex-vivo whole heart cadaveric model. Biomed Opt Express. 5(4), pp.1038-1049.
CA. Lyon, JL. Johnson, S. White, GB. Sala-Newby, SJ. George (2014). EC4, a truncation of soluble N-cadherin, reduces vascular smooth muscle cell apoptosis and markers of atherosclerotic plaque instability. Molecular Therapy - Methods and Clinical Development. 1,
M. Dabagh, W. Takabe, P. Jalali, S. White, H. Jo (2013). Hemodynamic Features in Stenosed Coronary Arteries: CFD Analysis Based on Histological Images. Journal of Applied Mathematics. 2013, pp.1-11.
SJ. White, EM. Hayes, S. Lehoux, JY. Jeremy, AJG. Horrevoets, et al. AC. Newby. (2011). Characterization of the Differential Response of Endothelial Cells Exposed to Normal and Elevated Laminar Shear Stress. Journal of Cellular Physiology. 226(11), pp.2841-2848.
SJ. White, GB. Sala-Newby, AC. Newby (2011). Overexpression of scavenger receptor LOX-1 in endothelial cells promotes atherogenesis in the ApoE(-/-) mouse model. Cardiovasc Pathol. 20(6), pp.369-373.
SJ. White, ED. Papadakis, CA. Rogers, JL. Johnson, EAL. Biessen, et al. AC. Newby. (2008). In vitro and in vivo analysis of expression cassettes designed for vascular gene transfer. Gene Ther. 15(5), pp.340-346.
CKM. Wong, T. Lai, S. White, E. Sheffield, MH. Wheeler, et al. CEH. Stewart, JR. Farndon. (2007). Characterization of the insulin-like growth factor axis and Wilms' tumour suppressor gene in hyperparathyroidism. Br J Surg. 94(10), pp.1232-1241.
SJ. White, RE. Simmonds, DA. Lane, AH. Baker (2005). Efficient isolation of peptide ligands for the endothelial cell protein C receptor (EPCR) using candidate receptor phage display biopanning. Peptides. 26(7), pp.1264-1269.
CG. Nicol, D. Graham, WH. Miller, SJ. White, TAG. Smith, et al. SA. Nicklin, SC. Stevenson, AH. Baker. (2004). Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats. Mol Ther. 10(2), pp.344-354.
DM. Duerr, SJ. White, HJ. Schluesener (2004). Identification of peptide sequences that induce the transport of phage across the gastrointestinal mucosal barrier. J Virol Methods. 116(2), pp.177-180.
SA. Nicklin, SJ. White, CG. Nicol, DJ. Von Seggern, AH. Baker (2004). In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors. J Gene Med. 6(3), pp.300-308.
ED. Papadakis, SA. Nicklin, AH. Baker, SJ. White (2004). Promoters and control elements: designing expression cassettes for gene therapy. Curr Gene Ther. 4(1), pp.89-113.
SJ. White, SA. Nicklin, H. Büning, MJ. Brosnan, K. Leike, et al. ED. Papadakis, M. Hallek, AH. Baker. (2004). Targeted gene delivery to vascular tissue in vivo by tropism-modified adeno-associated virus vectors. Circulation. 109(4), pp.513-519.
MA. Soel, A. Irwin, P. Gaultney, SG. White, SW. McHugh (2002). High-end infrared imaging sensor evaluation system. SPIE Proceedings. 4719, pp.172-188.
SJ. White, AC. Newby (2002). Gene therapy for all aspects of vein-graft disease. J Card Surg. 17(6), pp.549-555.
SA. Nicklin, PN. Reynolds, MJ. Brosnan, SJ. White, DT. Curiel, et al. AF. Dominiczak, AH. Baker. (2001). Analysis of cell-specific promoters for viral gene therapy targeted at the vascular endothelium. Hypertension. 38(1), pp.65-70.
SJ. White, SA. Nicklin, T. Sawamura, AH. Baker (2001). Identification of peptides that target the endothelial cell-specific LOX-1 receptor. Hypertension. 37(2 Pt 2), pp.449-455.
SA. Nicklin, SJ. White, SJ. Watkins, RE. Hawkins, AH. Baker (2000). Selective targeting of gene transfer to vascular endothelial cells by use of peptides isolated by phage display. Circulation. 102(2), pp.231-237.
SJ. White, SM. Page, P. Margaritis, GG. Brownlee (1998). Long-term expression of human clotting factor IX from retrovirally transduced primary human keratinocytes in vivo. Hum Gene Ther. 9(8), pp.1187-1195.
SJ. White, AC. Newby (2010). Metalloproteinases, the Endothelium, and Atherosclerosis. In: Atherosclerosis: Molecular and Cellular Mechanisms. Wiley, pp.155-172.
S. Satta, M. McElroy, A. Langford-Smith, G. Ferris, J. Teasdale, et al. Y. Kim, G. Niccoli, A. Tanjeko, J. Serre, G. Hazell, G. Sala-Newby, P. Wang, J. Johnson, M. Humphries, G. Gayan-Ramirez, P. Libby, F. Crea, H. Degens, F. Gijsen, T. Johnson, A. Keshmiri, Y. Alexander, A. Newby, S. White. (2019). A PIVOTAL ROLE FOR NRF2 IN ENDOTHELIAL DETACHMENT- IMPLICATIONS FOR ENDOTHELIAL EROSION OF STENOTIC PLAQUES. In: HEART. Manchester, ENGLAND, 3/6/2019. pp.A118-A118.
Y. Qiu, R. Ramnath, S. Jenner, S. Fawaz, K. Arkill, et al. C. Neal, P. Verkade, S. White, A. Salmon, M-S. Suleiman, G. Welsh, R. Foster, P. Madeddu, S. Satchell. (2019). DIABETIC CARDIOMYOPATHY IS ASSOCIATED WITH LOSS OF ENDOTHELIAL GLYCOCALYX IN CORONARY MICROVESSELS AND ANGIOPOIETIN 1 RESTORES ENDOTHELIAL GLYCOCALYX AND CORRECTS CARDIAC FUNCTION. In: HEART. Manchester, ENGLAND, 3/6/2019. pp.A143-A143.
S. Satta, M. Mcelroy, AW. Langford-Smith, G. Ferris, J. Teasdale, et al. Y. Kim, G. Niccoli, TT. Ajime, G. Ghayan-Ramirez, J. Serre, G. Hazell, GS. Newby, P. Wang, J. Johnson, M. Humphries, F. Crea, H. Degens, F. Gijsen, T. Johnson, A. Keshmiri, Y. Alexander, A. Newby, S. White. (2019). High-Level Nrf2 Activation Promotes Endothelial Detachment - Implications for Acute Coronary Syndromes Triggered by Endothelial Erosion of Plaques. In: JOURNAL OF VASCULAR RESEARCH. Maastricht, NETHERLANDS, 15/4/2019. pp.71-71.
S. White, S. Satta, G. Hazell, J. Teasdale, G. Sala-Newby, et al. T. Johnson, J. Johnson, A. Newby, Y. Alexander. (2018). 134 Osgin1 and osgin2 regulate adhesion of HCAEC and potentially contribute to endothelial erosion overlying stenotic plaques. In: Basic Science. Manchester, ENGLAND, 4/6/2018. pp.A97-A98.
S. White (2017). The response of the dysfunctional endothelium to elevated flow - implications for plaque disruption. In: Acta Physiologica. Vienna, Austria, 13/9/2017. pp.32-32.
A. Ward, SJ. White, GD. Angelini, SJ. George, M. Zakkar (2016). Inhibiting NF-KB classical activation prevents inflammation in endothelial cells in response to acute high shear stress. In: EUROPEAN HEART JOURNAL. Rome, ITALY, 27/8/2016. pp.1312-1313.
G. Hazell, JE. Teasdale, G. Sala-Newby, AC. Newby, SJ. White (2014). Shear stress and inflammation modulate the expression of Peptidase Inhibitor 16 (PI16) in human coronary artery endothelial cells (HCAECs). In: Atherosclerosis. Queens Coll, Cambridge, ENGLAND, 25/9/2014. pp.e8-e9.
SJ. White, SA. Nicklin, H. Buning, CG. Nicol, M. Hallek, et al. ED. Papadakis, C. Hsu, DJ. Von Seggern, AH. Baker. (2003). Targeting of adenoviral and adeno-associated viral vectors selectively to endothelial cells using novel 12-mer peptides isolated by phage display. In: MOLECULAR THERAPY. WASHINGTON, D.C., 4/6/2003. pp.S344-S345.