Dr Jane Sarginson

Who am I?

Jane Sarginson completed her undergraduate degree in Biochemistry
at the University of Bath in 1998. She then undertook a PhD on the role of
genetics in the development and clinical course of schizophrenia at the
University of Aberdeen, where she completed a post-doc in population genetics
before moving to Stanford University to work in pharmacogenetics. She then took
a career break before moving to Manchester to work first at the University of
Manchester and then MMU.

Her research focus is in the field of stratified medicine.
Mainly identifying genetic and environmental risk factors for the development
of common mental health disorder, biomarkers for antidepressant and antipsychotic
treatment response, and the study of mental and physical health comorbidities.
To do this uses different data sources, including data from clinical trials,
population samples and anonymised healthcare records.

Why do I teach?

Genetics is a rapidly evolving field, which contributes to a
wide range of research areas, ranging from conservation and evolution to gene
environment interaction and personalised medicine, so it’s important to always keep
learning. I enjoy teaching because it helps me keep up to date and allows me to
share in the enthusiasm of the staff, students and other professionals within
the field of health focused genetics.

How I’ll teach you

My approach to teaching mainly focuses on the current or
potential uses of genetics and other areas of biological sciences in healthcare
and improving the students understanding of the basic principles underlying
these uses.

Publications

• Journal articles

  K. Abel, H. Heuvelman, D. Rai, N. Timpson, J. Sarginson, et al. R. Shallcross, H. Mitchell, H. Hope, R. Emsley. (2019). Intelligence in offspring born to women exposed to intimate partner violence: a population-based cohort study. Wellcome Open Research. 2019(4),

  X. Gonda, J. Sarginson, N. Eszlari, P. Petschner, ZG. Toth, et al. D. Baksa, G. Hullam, IM. Anderson, JFW. Deakin, G. Juhasz, G. Bagdy. (2017). A new stress sensor and risk factor for suicide: The T allele of the functional genetic variant in the GABRA6 gene. Scientific Reports. 7, pp.12887-12887.

  J. Sarginson, RT. Webb, SJ. Stocks, A. Esmail, S. Garg, et al. DM. Ashcroft. (2017). Temporal trends in antidepressant prescribing to children in UK primary care, 2000–2015. Journal of Affective Disorders. 210, pp.312-318.

  JE. Sarginson, JD. Killen, LC. Lazzeroni, SP. Fortmann, HS. Ryan, et al. N. Ameli, AF. Schatzberg, GM. Murphy. (2015). Response to Transdermal Selegiline Smoking Cessation Therapy and Markers in the 15q24 Chromosomal Region. Nicotine & Tobacco Research. 17(9), pp.1126-1133.

  A. Ray, L. Tennakoon, J. Keller, JE. Sarginson, HS. Ryan, et al. GM. Murphy, LC. Lazzeroni, MH. Trivedi, JH. Kocsis, C. DeBattista, AF. Schatzberg. (2015). ABCB1 (MDR1) predicts remission on P-gp substrates in chronic depression. The Pharmacogenomics Journal. 15(4), pp.332-339.

  R. Schabetsberger, F. Økland, D. Kalfatak, U. Sichrowsky, M. Tambets, et al. K. Aarestrup, C. Gubili, J. Sarginson, B. Boufana, R. Jehle, G. Dall’Olmo, MJ. Miller, A. Scheck, R. Kaiser, G. Quartly. (2015). Genetic and migratory evidence for sympatric spawning of tropical Pacific eels from Vanuatu. Marine Ecology Progress Series. 521, pp.171-187.

  JE. Sarginson, JFW. Deakin, IM. Anderson, D. Downey, E. Thomas, et al. R. Elliott, G. Juhasz. (2014). Neuronal Nitric Oxide Synthase (NOS1) Polymorphisms Interact with Financial Hardship to Affect Depression Risk. Neuropsychopharmacology. 39(12), pp.2857-2866.

  AF. Schatzberg, J. Keller, L. Tennakoon, A. Lembke, G. Williams, et al. FB. Kraemer, JE. Sarginson, LC. Lazzeroni, GM. Murphy. (2014). Erratum: HPA axis genetic variation, cortisol and psychosis in major depression. Molecular Psychiatry. 19(10), pp.1151-1151.

  AF. Schatzberg, J. Keller, L. Tennakoon, A. Lembke, G. Williams, et al. FB. Kraemer, JE. Sarginson, LC. Lazzeroni, GM. Murphy. (2014). HPA axis genetic variation, cortisol and psychosis in major depression. Molecular Psychiatry. 19(2), pp.220-227.

  GM. Murphy, JE. Sarginson, HS. Ryan, R. O’Hara, AF. Schatzberg, et al. LC. Lazzeroni. (2013). BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depression. Pharmacogenetics and Genomics. 23(6), pp.301-313.

  JE. Sarginson, JD. Killen, LC. Lazzeroni, SP. Fortmann, HS. Ryan, et al. AF. Schatzberg, GM. Murphy. (2011). Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5‐A3‐B4) predict severity of nicotine addiction and response to smoking cessation therapy. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 156(3), pp.275-284.

  JE. Sarginson, LC. Lazzeroni, HS. Ryan, BD. Ershoff, AF. Schatzberg, et al. GM. Murphy. (2010). ABCB1 (MDR1) polymorphisms and antidepressant response in geriatric depression. Pharmacogenetics and Genomics. 20(8), pp.467-475.

  JE. Sarginson, LC. Lazzeroni, HS. Ryan, AF. Schatzberg, GM. Murphy (2010). FKBP5 polymorphisms and antidepressant response in geriatric depression. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 153B(2), pp.554-560.

  F. Zhang, J. Sarginson, C. Crombie, N. Walker, D. StClair, et al. D. Shaw. (2006). Genetic association between schizophrenia and the DISC1 gene in the Scottish population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 141B(2), pp.155-159.

  H. Stefansson, J. Sarginson, A. Kong, P. Yates, V. Steinthorsdottir, et al. E. Gudfinnsson, S. Gunnarsdottir, N. Walker, H. Petursson, C. Crombie, A. Ingason, JR. Gulcher, K. Stefansson, DS. Clair. (2003). Association of Neuregulin 1 with Schizophrenia Confirmed in a Scottish Population. The American Journal of Human Genetics. 72(1), pp.83-87.

• Conferences