- 200 years
- Study
- International
- Business and employers
- Research
- About us
https://webcdn.mmu.ac.uk/profiles/img/profile-images/mewis.png
Ryan Mewis graduated from the University of Hull with a MChem (Hons) in 2005 and subsequently obtained a PhD in inorganic chemistry from the same institution by working on the “Synthesis of Tetraazamacrocycles: Biomedical Applications” under the supervision of Drs Archibald and Boyle. In 2009 he joined the group of Professor Simon Duckett at the University of York as a Postdcotoral Fellow to work on a project related to the hyperpolarisation technique SABRE (Signal Amplification By Reversible Exchange) entitled the “Chemical Aspects of Hyperpolarisation”. This project, which was part of a joint collaboration with Professor Gary Green (University of York), was focused on developing what is primarily a spectroscopic technique, to one that can be used in clinical diagnosis.
In February 2015, Dr Mewis joined the staff at Manchester Metropolitan University as a Lecturer in Inorganic Chemistry. He was promoted to Senior Lecturer in 2016.
Dr Mewis is a member of the Royal Society of Chemistry (RSC).
Prospective students looking for either MSc or PhD postions are strongly encouraged to contact Dr Ryan Mewis prior to applying.
I teach because I enjoy the challenge of empowering the next generation of chemists with the knowledge that they need to move on with their chosen careers. I am a firm believer in research-led teaching and utilise examples from current and past research exploits where possible.
I recognise that obtaining a degree is a long and sometimes arduous journey - I know that I worked very hard for my degree. One of the greatest joys of my job is seeing students obtaining the best degree possible, especially when they have suffered setbacks along the way. I am always happy to help students who are struggling, and even more so when the student in question has invested substantial effort in trying to elucidate the answer for themselves.
"It always seems impossible until it's done."
Nelson Mandela 1918-2013
I teach using lectures, which incorporate formative assessments so that students can appraise their own learning, alongisde tutorials that are student led. I also facilitate laboratory classes at a number of levels of our courses. I also develop new experiments for laboratory classes to enhance student learning with associated virtual learning environment support so that students can appraise their own learning and develop confidence prior to entering the laboratory.
I am also involved in the development of smart worksheets for assessment purposes so that students can obtain instantaneous feedback on their work.
2005-2009 PhD “Synthesis of Tetraazamacrocycles: Biomedical Applications”
The University of Hull, Department of Chemistry
Supervisors: Dr S. J. Archibald and Dr R. W. Boyle
2001-2005 MChem (Hons) Chemistry (First Class), University of Hull
Jan 2013-Jan 2015 Research Fellow based in CHyM (Centre for Hyperpolarisation in MRI) at the University of York
Jan 2012- Jan 2013 Research and teaching fellow at the University of York
Mar 2009- Jan 2012 Post-doctoral researcher at the University of York
I currently organise the Chemistry Research Seminars
Chemistry is an exciting and diverse subject that, as the middle science, also encompasses aspects of physics and biology. Chemists are at the forefront of key scientific discoveries that improve our daily lives such as helping to combat disease or producing stronger and more durable materials.
Obtaining a degree in chemistry doesn't stop there - it will empower you with valuable transferable skills such as problem solving, team-working and independency (particularly of importance for project modules). A chemistry degree doesn't mean that you have to go on to do a chemistry orientated job, instead it gives you wide-ranging opportunities when you have graduated. However, if a chemistry orientated job is what you want to go on to do, then you will be equipped with relevant and up-to-date analytical skills, reinforced with the relevant chemical knowledge, that will be what future employers are looking for.
Teaching specialisms cover NMR and inorganic reaction mechanisms
I currently teach on:
6F7Z2103 Further Topics in Analysis, Synthesis & Catalytic Chemistry
6F7Z2104 Frontiers in Pharmaceutical Chemistry
6F7Z2002 Frontiers in Chemical and Environmental Science
6F7Z2001 Advanced Project and Personal Development (Unit leader)
6F6Z2101 Project and Personal Development
6F5Z2017 Spectroscopy and instrumental Analysis (Csup)
6F5Z2110 Structure and Spectroscopy
6F5Z2102 Solid state, d-block and f-block Chemistry
6F5Z2101 Laboratory Techniques 2
6F4Z2111 Laboratory Techniques 1A (Unit Leader)
6F4Z2112 Laboratory Techniques 1B (Unit Leader)
6F3Z3006 Introductoruy Chemical Reactions and Mechanisms
6F3Z3005 Principles of Chemistry
I am also the year leader for year 4 of the MChem course
Current students
Emily Griffiths - PhD (principal Supervisor)
Alex Wilcock - PhD (principal Supervisor)
Conner Maccullum – MSc (second supervisor)
David Dixon – PhD (second supervisor)
Previous Students
Faye Own – MSc (graduated 2017 (second supervisor))
Thomas Tennant – MSc (graduated 2018 (principal supervisor))
Christopher Turnbull – MSc (graduated 2019 (second supervisor))
Armita Hayathakbsh – MSc (graduated 2019 (principal supervisor))
Thomas Robertson – PhD (graduated 2020 (principal supervisor))
Matthew Hulme – PhD (graduated 2020 (second supervisor))
Nicolas Gilbert – PhD (graduated 2021 (second supervisor))
Jack Marron – PhD (second supervisor)
Soliman Alkirit – PhD (second supervisor)
J. Hena Hussain – MSc (graduated 2020 (second supervisor))
Filip Zukowicz – MSc (second supervisor)
Prospective students looking for either MSc or PhD postions are strongly encouraged to contact Dr Ryan Mewis prior to applying.
I work very closely with Dr Oliver Sutcliffe (MMU) on Novel Psychoactive Substance based projects. I have also published extensively with Prof. E. Kate Kemsley (Quadram Institute) on how to use automated NMR for the detection and qualitative analysis of drugs within a seized sample.
PJ. Rayner, MJ. Burns, AM. Olaru, P. Norcott, M. Fekete, et al. GGR. Green, LAR. Highton, RE. Mewis, SB. Duckett. (2017). Delivering strong (1)H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange. Proceedings of the National Academy of Sciences of the United States of America. 114(16),
AJ. Ruddlesden, RE. Mewis, GGR. Green, AC. Whitwood, SB. Duckett (2015). Catalytic Transfer of Magnetism Using a Neutral Iridium Phenoxide Complex. Organometallics. 34(12), pp.2997-3006.
TBR. Robertson, LJ. Clarke, RE. Mewis (2022). Rapid SABRE Catalyst Scavenging Using Functionalized Silicas. Molecules. 27(2), pp.332-332.
RE. Mewis (2021). Signal amplification by reversible exchange (SABRE). Magnetic Resonance in Chemistry. 59(12), pp.1175-1176.
N. Gilbert, RE. Mewis, OB. Sutcliffe (2020). Classification of fentanyl analogues through principal component analysis (PCA) and hierarchical clustering of GC–MS data. Forensic Chemistry. 21, pp.100287-100287.
JH. Hussain, N. Gilbert, A. Costello, CJ. Schofield, EK. Kemsley, et al. OB. Sutcliffe, RE. Mewis. (2020). Quantification of MDMA in seized tablets using benchtop 1H NMR spectroscopy in the absence of internal standards. Forensic Chemistry. 20, pp.100263-100263.
RE. Mewis, SJ. Archibald (2019). Side-bridged cyclam transition metal complexes bearing a phenolic ether or a phenolate pendent arm. Polyhedron. 171, pp.578-589.
LH. Antonides, RM. Brignall, A. Costello, J. Ellison, SE. Firth, et al. N. Gilbert, BJ. Groom, SJ. Hudson, MC. Hulme, J. Marron, ZA. Pullen, TBR. Robertson, CJ. Schofield, DC. Williamson, EK. Kemsley, OB. Sutcliffe, RE. Mewis. (2019). Rapid Identification of Novel Psychoactive and Other Controlled Substances Using Low-Field 1H NMR Spectroscopy. ACS Omega. 4(4), pp.7103-7112.
AM. Olaru, TBR. Robertson, JS. Lewis, A. Antony, W. Iali, et al. RE. Mewis, SB. Duckett. (2018). Extending the Scope of 19F Hyperpolarization through Signal Amplification by Reversible Exchange in MRI and NMR Spectroscopy. ChemistryOpen. 7(1), pp.97-105.
PJ. Rayner, MJ. Burns, AM. Olaru, P. Norcott, M. Fekete, et al. GGR. Green, LAR. Highton, RE. Mewis, SB. Duckett. (2017). Delivering strong (1)H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange. Proceedings of the National Academy of Sciences of the United States of America. 114(16),
F. Fernandez Diaz-Rullo, F. Zamberlan, RE. Mewis, M. Fekete, L. Broche, et al. LA. Cheyne, S. Dall'Angelo, SB. Duckett, D. Dawson, M. Zanda. (2017). Synthesis and hyperpolarisation of eNOS substrates for quantification of NO production by (1)H NMR spectroscopy. Bioorganic and Medicinal Chemistry. 25(10), pp.2730-2742.
RE. Mewis, AI. Aranburu Leiva, SL. Benjamin, SK. Langley (2016). Crystal structure of 2,4-di-tert-butyl-6-(hydroxymethyl)phenol. Acta Crystallographica Section E: Crystallographic Communications. 72, pp.1614-1617.
RD. Maples, AN. Cain, BP. Burke, JD. Silversides, RE. Mewis, et al. T. D'huys, D. Schols, DP. Linder, SJ. Archibald, TJ. Hubin. (2016). Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes. Chemistry: A European Journal. 22(36), pp.12916-12930.
P. Rovedo, S. Knecht, T. Bäumlisberger, AL. Cremer, SB. Duckett, et al. RE. Mewis, GGR. Green, M. Burns, PJ. Rayner, D. Leibfritz, JG. Korvink, J. Hennig, G. Pütz, D. Von Elverfeldt, JB. Hövener. (2016). Molecular MRI in the Earth's Magnetic Field Using Continuous Hyperpolarization of a Biomolecule in Water. Journal of Physical Chemistry B. 120(25), pp.5670-5677.
SB. Duckett, RE. Mewis (2015). ChemInform Abstract: Improving NMR and MRI Sensitivity with Para Hydrogen. ChemInform. 46(26),
AJ. Ruddlesden, RE. Mewis, GGR. Green, AC. Whitwood, SB. Duckett (2015). Catalytic Transfer of Magnetism Using a Neutral Iridium Phenoxide Complex. Organometallics. 34(12), pp.2997-3006.
M. Fekete, OW. Bayfield, SB. Duckett, S. Hart, RE. Mewis, et al. N. Pridmore, PJ. Rayner, A. Whitwood. (2014). Correction to Iridium(III) Hydrido N-Heterocyclic Carbene–Phosphine Complexes as Catalysts in Magnetization Transfer Reactions. Inorganic Chemistry. 53(5), pp.2749-2749.
M. Fekete, OW. Bayfield, SB. Duckett, S. Hart, RE. Mewis, et al. N. Pridmore, PJ. Rayner, A. Whitwood. (2014). Correction to Iridium(III) Hydrido N-Heterocyclic Carbene–Phosphine Complexes as Catalysts in Magnetization Transfer Reactions. Inorganic chemistry. 53(5), pp.2749-2749.
JB. Hövener, N. Schwaderlapp, R. Borowiak, T. Lickert, SB. Duckett, et al. RE. Mewis, RW. Adams, MJ. Burns, LAR. Highton, GGR. Green, A. Olaru, J. Hennig, D. Von Elverfeldt. (2014). Toward biocompatible nuclear hyperpolarization using signal amplification by reversible exchange: Quantitative in situ spectroscopy and high-field imaging. Analytical Chemistry. 86(3), pp.1767-1774.
SB. Duckett, RE. Mewis (2013). Improving NMR and MRI sensitivity with parahydrogen. Top Curr Chem. 338, pp.75-103.
RA. Green, RW. Adams, SB. Duckett, RE. Mewis, DC. Williamson, et al. GGR. Green. (2012). The theory and practice of hyperpolarization in magnetic resonance using parahydrogen. Prog Nucl Magn Reson Spectrosc. 67, pp.1-48.
R. Smith, D. Huskens, D. Daelemans, RE. Mewis, CD. Garcia, et al. AN. Cain, TNC. Freeman, C. Pannecouque, E. De Clercq, D. Schols, TJ. Hubin, SJ. Archibald. (2012). CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles. Dalton Trans. 41(37), pp.11369-11377.
SB. Duckett, RE. Mewis (2012). Application of parahydrogen induced polarization techniques in NMR spectroscopy and imaging. Acc Chem Res. 45(8), pp.1247-1257.
LS. Lloyd, RW. Adams, M. Bernstein, S. Coombes, SB. Duckett, et al. GGR. Green, RJ. Lewis, RE. Mewis, CJ. Sleigh. (2012). Utilization of SABRE-derived hyperpolarization to detect low-concentration analytes via 1D and 2D NMR methods. J Am Chem Soc. 134(31), pp.12904-12907.
AE. Sparke, CM. Fisher, RE. Mewis, SJ. Archibald (2010). Synthesis, structure and reactivity of 1-(4-nitrobenzyl)-2-chloromethyl benzimidazole. Tetrahedron Letters. 51(36), pp.4723-4726.
RE. Mewis, SJ. Archibald (2010). Biomedical applications of macrocyclic ligand complexes. Coordination Chemistry Reviews. 254(15-16), pp.1686-1712.
RE. Mewis, H. Savoie, SJ. Archibald, RW. Boyle (2009). Synthesis and phototoxicity of polyethylene glycol (PEG) substituted metal-free and metallo-porphyrins: effect of PEG chain length, coordinated metal, and axial ligand. Photodiagnosis Photodyn Ther. 6(3-4), pp.200-206.
A. Equbal, R. Mewis (2023). Hyperpolarisation Techniques. In: Nuclear Magnetic Resonance Volume 49. Royal Society of Chemistry,
RE. Mewis, A. Wilcock (2022). Hyperpolarisation Techniques. In: Nuclear Magnetic Resonance: Volume 48. Royal Society of Chemistry,
TBR. Robertson, RE. Mewis (2018). Perspective on the Hyperpolarisation Technique Signal Amplification by Reversible Exchange (SABRE) in NMR Spectroscopy and MR Imaging. Elsevier, pp.145-212.
SB. Duckett, RE. Mewis (2014). Erratum to: Improving NMR and MRI Sensitivity with Parahydrogen. In: Hyperpolarization Methods in NMR Spectroscopy. Springer Berlin Heidelberg, pp.E1-E1.
SB. Duckett, RE. Mewis (2012). Improving NMR and MRI Sensitivity with Parahydrogen. In: Hyperpolarization Methods in NMR Spectroscopy. Springer Berlin Heidelberg, pp.75-103.
(1) T. B. R. Robertson, N. Gilbert, O. B. Sutcliffe, R. E. Mewis “Hyperpolarisation of Mirfentanil by SABRE in the presence of heroin” ChemPhysChem 2021 ACCEPTED Special issue research article on Parahydrogen http://dx.doi.org/10.1002/cphc.202100165
(2) M. C. Hulme, A. Hayatbakhsh, R. M. Brignall, N. Gilbert, A. Costello, C. J. Schofield, D. C. Williamson, E. K. Kemsley, O. B. Sutcliffe and R. E. Mewis “Detection, discrimination and quantification of amphetamine, cathinone and nor-ephedrine regioisomers using benchtop 1H and 19F NMR spectroscopy” Mag. Reson. Chem. 2021 ACCEPTED. Special issue research article on NMR for forensics doi: 10.1002/mrc.5156
I organised the MERCIA (Middle England Regional Chemistry Interactive Alliance) December 2018 regional meeting at MMU
Member of the Subject Expert Grant Assessment Panel (SEGAP) for the RSC
I also review papers for Analytical Methods, Journal of Physical Chemistry, Analytical Chemistry, Reaction Kinetics, Mechanisms and Catalysis, Chemistry - A European Journal, Journal of the American Chemical Society, Journal of Chemical Education, Mangetic Resonance in Chemistry and Forensic Chemistry
See here for more details https://publons.com/author/981223/ryan-e-mewis#profile
£50,000 - match funded studentship with Oxford Instruments (Dr David Williamson) and Dr Oliver Sutcliffe (MMU)
I act as a consultant for Oxford Instruments
A method for screening psychoactive substances (GB1800377.2)
In 2019 I was awarded best Undergraduate Supervisor of the year and best Postgraduate Supervisor at the Manchester Metropolitan University Teaching Awards
Member of the Subject Expert Grant Assessment Panel for the RSC
Member of the Royal Society of Chemistry