Dr Jason Ashworth
Principal Lecturer
My profile
Biography
Academic and professional qualifications
FHEA PGCAP CBiol PhD BSc
Other academic service (administration and management)
Head of Division (Biomedical Sciences)
External examiner roles
External Examiner: Newcastle & Teeside University
Expert reviewer for external funding bodies
Dr Ashworth has reviewed for several journals including the Journal of the American Medical Association (JAMA) and the Nature Publishing Group (NPG).
Teaching
Why study…
The BSc (Hons) Healthcare Science (Life Sciences) degree is a professional qualification required to legally register and practise in the healthcare arena (e.g. NHS or private sector) as a biomedical scientist or healthcare science practitioner. You can choose from 3 routes (Cellular Sciences, Blood Sciences or Infection Sciences). You will complete a work-based placement that prepares you with the clinical skills and expertise required for healthcare science practice; including the diagnosis, monitoring and management of human diseases. During the degree you will develop detailed understanding and knowledge of the biomedical areas of your chosen specialist route. The programme is accredited by Health Education England (HEE) and the Institute of Biomedical Science (IBMS). The degree is also approved by the Health and Care Professions Council (HCPC).
The BSc (Hons) Biomedical Science degree will develop your understanding of the human body in relation to health and disease. You will learn about cell biology, human physiology, medical microbiology, immunology, haematology & transfusion, genetics, biochemistry and pathology. The course is very practical-based and you will develop skills in analytic and diagnostic techniques applicable to biomedical science. The programme is accredited by the Institute of Biomedical Science (IBMS) and the Royal Society of Biology (RSB).
See the MMU website for full course details and entry requirements etc.
Postgraduate teaching
Dr Ashworth teaches on the taught MSc Biomedical Science and MBiomedSci Biomedical Science programmes.
Subject areas
Healthcare Science (Biomedical & Life Sciences)
Supervision
Dr Ashworth supervises postgraduate research (MRes, MPhil, PhD) students.
Research outputs
Inflammation, Infection, Ageing & Tissue/Wound Repair
-
Chapters in books
Ashworth, J. (2023) 'Anti-inflammatory agent.' In Pak, S.C., Ooi, S.L., Micalos, P.S., Ghoneum, M.H. (ed.) Modified Rice Bran Arabinoxylan: Therapeutic Applications in Cancer and Other Diseases. Singapore: Springer, pp. 41-51.
-
Journal articles
Zhang, J., Ashworth, J., Xu, J., Xu, X., Ahmed, N., Slevin, M., Liu, D. (2021) 'Effect of puerarin on glutamine synthetase activity in rat retina following acute intraocular hypertension.' Research in Pharmaceutical Biotechnology, 8(1)
Liu, D., Kumar, S., Ashworth, J., Ali, K., Fadel, A., Guo, B., Slevin, M. (2021) 'CD105 (Endoglin): A Potential Anticancer Therapeutic Inhibits Mitogenesis and Map Kinase Pathway Activation.' Anticancer Research, 41(3) pp. 1219-1229.
El Mohtadi, M., Whitehead, K., Dempsey-Hibbert, N., Belboul, A., Ashworth, J. (2021) 'Estrogen deficiency – a central paradigm in age-related impaired healing?.' EXCLI Journal, 20pp. 99-116.
Mohtadi, M.E., Pilkington, L., Liauw, C.M., Ashworth, J.J., Dempsey-Hibbert, N., Belboul, A., Whitehead, K.A. (2020) 'Differential engulfment of staphylococcus aureus and pseudomonas aeruginosa by monocyte-derived macrophages is associated with altered phagocyte biochemistry and morphology.' EXCLI Journal, 19
Yau, M.W., McLaughlin, J., Maughan, R., Gilmore, W., Ashworth, J., Evans, G. (2018) 'A pilot study investigating the influence of glucagon-like peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian men.' Frontiers in Physiology, 9
Fadel, A., Ashworth, J., Plunkett, A., Mahmoud, Y., Ranneh, Y., Li, W. (2018) 'Improving the extractability of arabinoxylans and the molecular weight of wheat endosperm using extrusion processing..' Journal of Cereal Science, 84pp. 55-61.
Sproston, N.R., El Mohtadi, M., Slevin, M., Gilmore, W., Ashworth, J.J. (2018) 'The Effect of C-Reactive Protein Isoforms on Nitric Oxide Production by U937 Monocytes/Macrophages.' Frontiers in Immunology, 9pp. 1-14.
Sproston, N.R., Ashworth, J.J. (2018) 'Role of C-Reactive Protein at Sites of Inflammation and Infection.' Frontiers in Immunology, 9
Fadel, A., Plunkett, A., Li, W., Gyamfi, V., Nyaranga, R., Fadel, F., Dakak, S., Ranneh, Y., Salmon, Y., Ashworth, J.J. (2018) 'Modulation of Innate and Adaptive Immune Responses by Arabinoxylans.' Journal of Food Biochemistry, 42(2) pp. e12473-e12473.
Fadel, A., Mahmoud, A.M., Ashworth, J.J., Li, W., Ng, Y.L., Plunkett, A. (2018) 'Health-related effects and improving extractability of cereal arabinoxylans..' International Journal of Biological Macromolecules, 109pp. 819-831.
Fadel, A., Plunkett, A., Ashworth, J., Mahmoud, A.M., Ranneh, Y., El Mohtadi, M., Li, W. (2018) 'The effect of extrusion screw-speed on the water extractability and molecular weight distribution of arabinoxylans from defatted rice bran.' Journal of Food Science and Technology, 55(3) pp. 1201-1206.
Zhang, Z., Smith, C., Ashworth, J.J., Li, W. (2018) 'Regulation of inducible nitric oxide synthase by arabinoxylans with molecular characterisation from wheat flour in cultured human monocytes.' International Journal of Food Science and Technology, 53(5) pp. 1294-1302.
Fadel, A., Plunkett, A., Li, W., Ranneh, Y., Gyamfi, V., Salmon, Y., Nyaranga, R.R., Ashworth, J. (2018) 'Arabinoxylans from rice bran and wheat immunomodulatory potentials: A Review Article.' Nutrition & Food Science, 48(1) pp. 97-110.
Zhang, Z., Smith, C., Li, W., Ashworth, J. (2016) 'Characterization of Nitric Oxide Modulatory Activities of Alkaline-Extracted and Enzymatic-Modified Arabinoxylans from Corn Bran in Cultured Human Monocytes.' Journal of Agricultural and Food Chemistry, 64(43) pp. 8128-8137.
Liu, D., Andrade, S.P., Castro, P.R., Treacy, J., Ashworth, J., Slevin, M. (2016) 'Low Concentration of Sodium Butyrate from Ultrabraid+NaBu suture, Promotes Angiogenesis and Tissue Remodelling in Tendon-bones Injury.' Scientific Reports, 6
Boras, E., Slevin, M., Alexander, M.Y., Aljohi, A., Gilmore, W., Ashworth, J., Krupinski, J., Potempa, L.A., Al Abdulkareem, I., Elobeid, A., Matou-Nasri, S. (2014) 'Monomeric C-reactive protein and Notch-3 co-operatively increase angiogenesis through PI3K signalling pathway.' Cytokine, 69(2) pp. 165-179.
Yau, A.M.W., Moss, A.D., James, L.J., Gilmore, W., Ashworth, J.J., Evans, G.H. (2014) 'The influence of angiotensin converting enzyme and bradykinin receptor B2 gene variants on voluntary fluid intake and fluid balance in healthy men during moderate-intensity exercise in the heat.' Applied Physiology, Nutrition and Metabolism, 40(2) pp. 184-190.
Ashcroft, G.S., Jeong, M.J., Ashworth, J.J., Hardman, M., Jin, W., Moutsopoulos, N., Wild, T., McCartney-Francis, N., Sim, D., McGrady, G., Song, X.Y., Wahl, S.M. (2012) 'Tumor necrosis factor-alpha (TNF-α) is a therapeutic target for impaired cutaneous wound healing..' Wound Repair Regen, 20(1) pp. 38-49.
Ashworth, J.J., Smyth, J.V., Pendleton, N., Horan, M., Payton, A., Worthington, J., Ollier, W.E., Ashcroft, G.S. (2008) 'Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration..' Clin Genet, 73(1) pp. 55-61.
O'Hagan, S., Dunn, W.B., Knowles, J.D., Broadhurst, D., Williams, R., Ashworth, J.J., Cameron, M., Kell, D.B. (2007) 'Closed-loop, multiobjective optimization of two-dimensional gas chromatography/mass spectrometry for serum metabolomics..' Anal Chem, 79(2) pp. 464-476.
Gilliver, S.C., Ashworth, J.J., Ashcroft, G.S. (2007) 'The hormonal regulation of cutaneous wound healing..' Clin Dermatol, 25(1) pp. 56-62.
Gilliver, S.C., Ashworth, J.J., Mills, S.J., Hardman, M.J., Ashcroft, G.S. (2006) 'Androgens modulate the inflammatory response during acute wound healing..' J Cell Sci, 119(Pt 4) pp. 722-732.
Ashworth, J.J., Smyth, J.V., Pendleton, N., Horan, M., Payton, A., Worthington, J., Ollier, W.E., Ashcroft, G.S. (2005) 'The dinucleotide (CA) repeat polymorphism of estrogen receptor beta but not the dinucleotide (TA) repeat polymorphism of estrogen receptor alpha is associated with venous ulceration..' J Steroid Biochem Mol Biol, 97(3) pp. 266-270.
Mills, S.J., Ashworth, J.J., Gilliver, S.C., Hardman, M.J., Ashcroft, G.S. (2005) 'The sex steroid precursor DHEA accelerates cutaneous wound healing via the estrogen receptors..' J Invest Dermatol, 125(5) pp. 1053-1062.
Ashcroft, G.S., Ashworth, J.J. (2003) 'Potential role of estrogens in wound healing..' Am J Clin Dermatol, 4(11) pp. 737-743.
Ashcroft, G.S., Mills, S.J., Ashworth, J.J. (2002) 'Ageing and wound healing..' Biogerontology, 3(6) pp. 337-345.
-
Conference papers
Belboul, A., El Mohtadi, M., Ashworth, J. (2023) 'Poloxamer-Mediated Control of Biofilms on Polycarbonate Surfaces.' 27/9/2023 - 29/11/2023. pp. 44-44.
Belboul, A., Mohtadi, M., Vagg-Whitehead, K., Ashworth, J. (2023) 'Estrogen promotes macrophage-mediated clearance of biofilms in an in vitro model of an infected diabetic foot ulcer.' 11/9/2023 - 15/9/2023.
El Mohtadi, M., Vagg-Whitehead, K., Belboul, A., Fadel, A., Ashworth, J. (2023) 'Estrogen stimulates the clearance of wound bacteria by monocyte-derived macrophages via activation of estrogen-receptor alpha and actin cytoskeleton reorganization.' In Cold Spring Harbor Laboratory (CSHL): Microbial Pathogenesis and Host Response. Cold Spring Harbor Laboratory, New York, USA, 11/9/2023 - 15/9/2023.
Shah, S., El Mohtadi, M., Ashworth, J. (2023) 'Biobran (MGN-3) enhances host-pathogen interaction in an in vitro hyperglycaemic model of an infected diabetic foot ulcer via the CD14/TLR-4 pathway.' In Phagocytes Gordon Research Conference 2023: Molecular and Cellular Diversity in Host Defense and Inflammation. Waterville Valley, New Hampshire, United States, 4/6/2023 - 9/6/2023.
El Mohtadi, M., Percival, S., Ashworth, J. (2023) 'Pre-treatment with poloxamer surfactant augments estrogen-mediated bacterial clearance by phagocytes in an in vitro model of chronic wound biofilms.' In Phagocytes Gordon Research Conference 2023: Molecular and Cellular Diversity in Host Defense and Inflammation. Waterville Valley, New Hampshire, United States, 4/6/2023 - 9/6/2023.
Asif, M.S., El Mohtadi, M., Ashworth, J. (2023) 'Biobran (MGN-3) concurrently reverses lipopolysaccharide-induced elevation of CD14 and impairment of macrophage-mediated bacterial clearance in a model of diabetic wound biofilms.' In Phagocytes Gordon Research Conference 2023: Molecular and Cellular Diversity in Host Defense and Inflammation. Waterville Valley, New Hampshire, United States, 4/6/2023 - 9/6/2023.
Asif, M.S., Tan, S., El Mohtadi, M., Ashworth, J. (2023) 'Biobran (MGN-3) acts through toll-like receptor-4 (TRL-4) and reverses the detrimental effects of hyperglycaemia on phagocytosis.' In Phagocytes Gordon Research Seminar (GRS) 2023: Exploring Phagocyte Biology in Inflammation, Infection and Resolution. Waterville Valley, New Hampshire, United States, 3/6/2023 - 4/6/2023.
Shah, S., El Mohtadi, M., Ashworth, J. (2023) 'Determining the cellular and molecular mechanisms by which Biobran (MGN-3) mediates innate immunity in a hyperglycaemic model of a diabetic foot ulcer infection.' In Phagocytes Gordon Research Seminar (GRS) 2023: Exploring Phagocyte Biology in Inflammation, Infection and Resolution. Waterville Valley, New Hampshire, United States, 3/6/2023 - 4/6/2023.
Shah, S., El Mohtadi, M., Ashworth, J. (2022) 'Using MGN-3 to mediate innate immunity in a diabetic (hyperglycaemic) model of an infected chronic wound.' 12/7/2022 - 13/7/2022. pp. 12-12.
Belboul, A., El Mohtadi, M., Vagg-Whitehead, K., Ashworth, J. (2022) 'Effect of Hormone-Driven Ageing on Inflammatory Cell Clearance of Bacteria under Hyperglycaemic Conditions.' 23/4/2022 - 26/4/2022.
El Mohtadi, M., Belboul, A., Vagg-Whitehead, K., Ashworth, J. (2022) 'Estrogen augments the phagocytic function of macrophages through activation of estrogen-receptor alpha and actin cytoskeleton reorganisation.' 23/4/2022 - 26/4/2022.
Tomova, A.M., Hughes, J., Hunter, H., Brison, D., Ashworth, J., Murgatroyd, C., Carroll, M. (2020) 'The role of vasopressin in human sperm function.' In Fertility 2020 Conference. Edinburgh, 9/1/2020 - 11/1/2020.
El Mohtadi, M., Whitehead, K., Ashworth, J. (2019) 'Estrogen reverses the age-related impaired clearance of wound bacteria by human macrophages via activation of estrogen-receptor alpha and actin cytoskeleton reorganisation..' In 8th Congress of European Microbiologists (FEMS 2019). Glasgow, Scotland, 7/7/2019 - 11/7/2019. Federation of European Microbiological Societies (FEMS),
El Mohtadi, M., Whitehead, K., Ashworth, J. (2018) 'Estrogen stimulates phagocytosis by macrophages in both in vitro and ex vivo models of age-related impaired healing via the estrogen-receptor alpha..' 2/9/2018 - 5/9/2018.
Parry, C., El Mohtadi, M., Whitehead, K., Ashworth, J. (2018) 'Androgens inhibit phagocytosis by macrophages via the androgen receptor.' In 5th European Congress of Immunology. Amsterdam, Netherlands, 2/9/2018 - 5/9/2018.
El Mohtadi, M., Whitehead, K.A., Abdulmannan, F., Ashworth, J.J. (2017) 'Estrogen Enhances Host-Pathogen Interactions in an in vitro Model of Age-Related Impaired Healing..' In Microbial Pathogenesis and Host Responses. Cold Spring Harbor Laboratory, New York, 12/9/2017 - 16/9/2017.
Hall, N.R., Slevin, M., Gilmore, W., Ashworth, J.J. (2017) 'The pentameric, but not the monomeric, isoform of C-reactive protein (CRP) enhances phagocytosis of methicillin-resistant Staphylococcus aureus (MRSA); potential implications for treatment strategies..' In Microbial Pathogenesis and Host Response. Cold Spring Harbor Laboratory, New York, 12/9/2017 - 16/9/2017.
Li, W., Zhang, Z., Ashworth, J., Fowell, A., Wang, Q., Smith, C. (2017) 'Bioactive fiber: bioactivity of cereal arabinoxylans in relation to their sources and structure.' 1. 11/9/2017 - 12/9/2017.
El Mohtadi, M., Whitehead, K., Ashworth, J. (2017) 'Effect of sex steroid hormones (estrogen) on host-pathogen interactions in an in vitro model of age-related impaired healing..' In The 17th International Biodeterioration & Biodegradation Symposium. Manchester Metropolitan University, Manchester, UK., 6/9/2017 - 8/9/2017.
Hall, N., Slevin, M., Gilmore, W., Ashworth, J. (2015) 'C-reactive protein (CRP) isoforms & nitric oxide production in U937 monocytes and macrophages..' 30/5/2015 - 31/5/2015.
Yau, A., McLaughlin, J., Maughan, R.J., Gilmore, W., Ashworth, J.J., Evans, G.H. (2014) 'The influence of glucagon-like-peptide-1 receptor single nucleotide polymorphisms on gastric emptying rate in Caucasian men.' In Physiological Society Main Meeting. 31. London, UK, 30/6/2014 - 2/7/2014. The Physiological Society,
Yau, A., Moss, A., James, L.J., Hynes, J., Ashworth, J.J., Evans, G.H. (2011) 'Serum angiotensin I-converting enzyme response to exercise; no differential effect of genotype.' In International Sports Science and Sports Medicine Conference. 45. BMJ Publishing Group, pp. A4-A4.
Yau, A., Moss, A., James, L.J., Ashworth, J.J., Evans, G.H. (2011) 'The influence of bradykinin receptor B2 genetic variation on voluntary fluid intake and fluid balance.' In Physiological Society Main Meeting. 23. pp. PC201-PC201.
-
Presentations
Fadel, A., Plunkett, A., Li, W., Ashworth, J. (2018) Modulate your immune response using cereals. [Presentation] 17/4/2018.