Dr Nicolas Pionnier

Hegde, S., Marriott, A.E., Pionnier, N., Steven, A., Bulman, C., Gunderson, E., Vogel, I., Koschel, M., Ehrens, A., Lustigman, S., Voronin, D., Tricoche, N., Hoerauf, A., Hübner, M.P., Sakanari, J., Aljayyoussi, G., Gusovsky, F., Dagley, J., Hong, D.W., O'Neill, P., Ward, S.A., Taylor, M.J., Turner, J.D. (2024) 'Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis.' Frontiers in Microbiology, 15

Pionnier, N., Furlong-Silva, J., Colombo, S.A.P., Marriott, A.E., Chunda, V.C., Ndzeshang, B.L., Sjoberg, H., Archer, J., Steven, A., Wanji, S., Taylor, M.J., Turner, J.D. (2022) 'NKp46+ natural killer cells develop an activated/memory-like phenotype and contribute to innate immunity against experimental filarial infection.' Frontiers in Immunology, 13pp. 969340-969340.

Marriott, A.E., Furlong Silva, J., Pionnier, N., Sjoberg, H., Archer, J., Steven, A., Kempf, D., Taylor, M.J., Turner, J.D. (2022) 'A mouse infection model and long-term lymphatic endothelium co-culture system to evaluate drugs against adult Brugia malayi.' PLoS Neglected Tropical Diseases, 16(6) pp. e0010474-e0010474.

Akumtoh, D.N., Njouendou, A.J., Metuge, H.M., Sjoberg, H.T., Pionnier, N.P., Chunda, V.C., Gandjui, N.V.T., Ndzeshang, L.B., Fombad, F.F., Abong, R.A., Enyong, P.A., Fru-Cho, J., Esum, M.E., Ritter, M., Taylor, M.J., Turner, J.D., Wanji, S. (2021) 'Onchocerca ochengi male worms implanted in SCID mice and gerbil: relationship between microfilaridermia status of cows, nodular worm viability and fertility and worm survival in the rodents.' Experimental Parasitology, 229pp. 108143-108143.

Gallego, C., Vétillard, M., Calmette, J., Roriz, M., Marin-Esteban, V., Evrard, M., Aknin, M.L., Pionnier, N., Lefrançois, M., Mercier-Nomé, F., Bertrand, Y., Suarez, F., Donadieu, J., Ng, L.G., Balabanian, K., Bachelerie, F., Schlecht-Louf, G. (2021) 'CXCR4 signaling controls dendritic cell location and activation at steady state and in inflammation.' Blood, 137(20) pp. 2770-2784.

Furlong-Silva, J., Cross, S.D., Marriott, A.E., Pionnier, N., Archer, J., Steven, A., Merker, S.S., Mack, M., Hong, Y.K., Taylor, M.J., Turner, J.D. (2021) 'Tetracyclines improve experimental lymphatic filariasis pathology by disrupting interleukin-4 receptor-mediated lymphangiogenesis.' Journal of Clinical Investigation, 131(5)

Macfarlane, C.L., Quek, S., Pionnier, N., Turner, J.D., Wanji, S., Wagstaff, S.C., Taylor, M.J. (2020) 'The insufficiency of circulating miRNA and DNA as diagnostic tools or as biomarkers of treatment efficacy for Onchocerca volvulus.' Scientific Reports, 10(1)

Ndzeshang, L.B., Fombad, F.F., Njouendou, A.J., Chunda, V.C., Gandjui, N.V.T., Akumtoh, D.N., Chounna, P.W.N., Steven, A., Pionnier, N.P., Layland, L.E., Ritterid, M., Hoerauf, A., Taylor, M.J., Turner, J.D., Wanji, S. (2020) 'Generation of loa loa infective larvae by experimental infection of the vector, chrysops silacea.' PLoS Neglected Tropical Diseases, 14(8) pp. 1-15.

Pionnier, N., Sjoberg, H., Furlong-Silva, J., Marriott, A., Halliday, A., Archer, J., Steven, A., Taylo, M.J., Turn, J.D. (2020) 'Eosinophil-Mediated immune control of adult filarial nematode infection can proceed in the absence of IL-4 receptor signaling.' Journal of Immunology, 205(3) pp. 731-740.

Pionnier, N.P., Sjoberg, H., Chunda, V.C., Fombad, F.F., Chounna, P.W., Njouendou, A.J., Metuge, H.M., Ndzeshang, B.L., Gandjui, N.V., Akumtoh, D.N., Tayong, D.B., Taylor, M.J., Wanji, S., Turner, J.D. (2019) 'Mouse models of Loa loa.' Nature Communications, 10(1)

Bakowski, M.A., Shiroodi, R.K., Liu, R., Olejniczak, J., Yang, B., Gagaring, K., Guo, H., White, P.M., Chappell, L., Debec, A., Landmann, F., Dubben, B., Lenz, F., Struever, D., Ehrens, A., Frohberger, S.J., Sjoberg, H., Pionnier, N., Murphy, E., Archer, J., Steven, A., Chunda, V.C., Fombad, F.F., Chounna, P.W., Njouendou, A.J., Metuge, H.M., Ndzeshang, B.L., Gandjui, N.V., Akumtoh, D.N., Kwenti, T.D.B., Woods, A.K., Joseph, S.B., Hull, M.V., Xiong, W., Kuhen, K.L., Taylor, M.J., Wanji, S., Turner, J.D., Hübner, M.P., Hoerauf, A., Chatterjee, A.K., Roland, J., Tremblay, M.S., Schultz, P.G., Sullivan, W., Chu, X.J., Petrassi, H.M., McNamara, C.W. (2019) 'Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.' Science Translational Medicine, 11(491)

Taylor, M.J., Von Geldern, T.W., Ford, L., Hübner, M.P., Marsh, K., Johnston, K.L., Sjoberg, H.T., Specht, S., Pionnier, N., Tyrer, H.E., Clare, R.H., Cook, D.A.N., Murphy, E., Steven, A., Archer, J., Bloemker, D., Lenz, F., Koschel, M., Ehrens, A., Metuge, H.M., Chunda, V.C., Chounna, P.W.N., Njouendou, A.J., Fombad, F.F., Carr, R., Morton, H.E., Aljayyoussi, G., Hoerauf, A., Wanji, S., Kempf, D.J., Turner, J.D., Ward, S.A. (2019) 'Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis.' Science Translational Medicine, 11(483)

Sjoberg, H.T., Pionnier, N., Aljayyoussi, G., Metuge, H.M., Njouendou, A.J., Chunda, V.C., Fombad, F.F., Tayong, D.B., Gandjui, N.V.T., Akumtoh, D.N., Chounna, P.W.N., Ndzeshang, B.L., Lachaud, S., Tekle, F., Quirynen, L., Engelen, M., Baeten, B., Steven, A., Ward, S.A., Taylor, M.J., Wanji, S., Turner, J.D. (2019) 'Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models.' PLoS Neglected Tropical Diseases, 13(1)

Turner, J.D., Pionnier, N., Furlong-Silva, J., Sjoberg, H., Cross, S., Halliday, A., Guimaraes, A.F., Cook, D.A.N., Steven, A., Van Rooijen, N., Allen, J.E., Jenkins, S.J., Taylor, M.J. (2018) 'Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia.' PLoS Pathogens, 14(3)

Aljayyoussi, G., Tyrer, H.E., Ford, L., Sjoberg, H., Pionnier, N., Waterhouse, D., Davies, J., Gamble, J., Metuge, H., Cook, D.A.N., Steven, A., Sharma, R., Guimaraes, A.F., Clare, R.H., Cassidy, A., Johnston, K.L., Myhill, L., Hayward, L., Wanji, S., Turner, J.D., Taylor, M.J., Ward, S.A. (2018) 'Erratum: Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis (Scientific reports (2017) 7 1 (210)).' Scientific reports, 8(1)

Karadjian, G., Fercoq, F., Pionnier, N., Vallarino-Lhermitte, N., Lefoulon, E., Nieguitsila, A., Specht, S., Carlin, L.M., Martin, C. (2017) 'Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung.' PLoS Neglected Tropical Diseases, 11(5)

Aljayyoussi, G., Tyrer, H.E., Ford, L., Sjoberg, H., Pionnier, N., Waterhouse, D., Davies, J., Gamble, J., Metugene, H., Cook, D.A.N., Steven, A., Sharma, R., Guimaraes, A.F., Clare, R.H., Cassidy, A., Johnston, K.L., Myhill, L., Hayward, L., Wanji, S., Turner, J.D., Taylor, M.J., Ward, S.A. (2017) 'Short-course, high-dose rifampicin achieves Wolbachia depletion predictive of curative outcomes in preclinical models of lymphatic filariasis and onchocerciasis.' Scientific Reports, 7(1)

Tamarozzi, F., Turner, J.D., Pionnier, N., Midgley, A., Guimaraes, A.F., Johnston, K.L., Edwards, S.W., Taylor, M.J. (2016) 'Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis.' Scientific Reports, 6

Pionnier, N., Brotin, E., Karadjian, G., Hemon, P., Gaudin-Nomé, F., Vallarino-Lhermitte, N., Nieguitsila, A., Fercoq, F., Aknin, M.L., Marin-Esteban, V., Chollet-Martin, S., Schlecht-Louf, G., Bachelerie, F., Martin, C. (2016) 'Neutropenic Mice Provide Insight into the Role of Skin-Infiltrating Neutrophils in the Host Protective Immunity against Filarial Infective Larvae.' PLoS Neglected Tropical Diseases, 10(4)

Miest, J.J., Adamek, M., Pionnier, N., Harris, S., Matras, M., Rakus, K.T., Irnazarow, I., Steinhagen, D., Hoole, D. (2015) 'Differential effects of alloherpesvirus CyHV-3 and rhabdovirus SVCV on apoptosis in fish cells.' Veterinary Microbiology, 176(1-2) pp. 19-31.

Pionnier, N., Adamek, M., Miest, J.J., Harris, S.J., Matras, M., Rakus, K.L., Irnazarow, I., Hoole, D. (2014) 'C-reactive protein and complement as acute phase reactants in common carp Cyprinus carpio during CyHV-3 infection.' Diseases of Aquatic Organisms, 109(3) pp. 187-199.

Pionnier, N., Falco, A., Miest, J.J., Shrive, A.K., Hoole, D. (2014) 'Feeding common carp cyprinus carpio with β-glucan supplemented diet stimulates C-reactive protein and complement immune acute phase responses following PAMPs injection.' Fish and Shellfish Immunology, 39(2) pp. 285-295.

Falco, A., Miest, J.J., Pionnier, N., Pietretti, D., Forlenza, M., Wiegertjes, G.F., Hoole, D. (2014) 'β-Glucan-supplemented diets increase poly(I: C)-induced gene expression of Mx, possibly via Tlr3-mediated recognition mechanism in common carp (Cyprinus carpio).' Fish and Shellfish Immunology, 36(2) pp. 494-502.

Falco, A., Miest, J., Pionnier, N., Pietretti, D., Forlenza, M., Wiegertjes, G.F., Hoole, D. (2013) 'beta-glucan supplemented diets induce high and broad expression levels of TLR3 what explains protection conferred by these additives against viral infections in fish.' FISH & SHELLFISH IMMUNOLOGY, 34(6) pp. 1706-1706.

Pionnier, N., Falco, A., Miest, J., Frost, P., Irnazarow, I., Shrive, A., Hoole, D. (2013) 'Dietary beta-glucan stimulate complement and C-reactive protein acute phase responses in common carp (Cyprinus carpio) during an Aeromonas salmonicida infection.' FISH & SHELLFISH IMMUNOLOGY, 34(3) pp. 819-831.

Falco, A., Frost, P., Miest, J., Pionnier, N., Irnazarow, I., Hoole, D. (2012) 'Reduced inflammatory response to Aeromonas salmonicida infection in common carp (Cyprinus carpio L.) fed with β-glucan supplements.' Fish and Shellfish Immunology, 32(6) pp. 1051-1057.

Miest, J.J., Falco, A., Pionnier, N.P.M., Frost, P., Irnazarow, I., Williams, G.T., Hoole, D. (2012) 'The influence of dietary β-glucan, PAMP exposure and Aeromonas salmonicida on apoptosis modulation in common carp (Cyprinus carpio).' Fish and Shellfish Immunology, 33(4) pp. 846-856.

Pionnier, N., Sjoberg, H., Metuge, H., Chunda, V., Njouendou, A., Fombad, F., Ndzeshang, B., Taylor, M., Wanji, S., Turner, J. (2019) 'DEVELOPMENT, VALIDATION AND IMPLEMENTATION OF PRECLINICAL MODELS OF LOIASIS AND ONCHOCERCIASIS TO IDENTIFY CANDIDATE MACROFILARICIDAL DRUGS.' 113. OXFORD UNIV PRESS, pp. S122-S122.

Sjoberg, H., Pionnier, N., Steven, A., Alyyoussi, G., Quirynen, L., Engelen, M., Baeten, B., Ward, S.A., Taylor, M.J., Turner, J.D. (2017) 'LACK OF SIGNIFICANT MICROFILARICIDAL EFFICACY OF PARENTERAL OR ORAL BIOAVAILABLE FLUBENDAZOLE FORMULATIONS IN A BRUGIA MALAYI MICROFILARAEMIC MOUSE MODEL.' In 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH). 95. Atlanta, GA, 13/11/2016 - 16/11/2016. AMER SOC TROP MED & HYGIENE, pp. 153-153.

Sjoberg, H., Pionnier, N., Metugene, H., Njouendou, A., Fombad, F., Ndongmo, P., Tayong, D., Ndzeshang, B., Steven, A., Cook, D., Alyaoussi, G., Ward, S., Taylor, M., Wanji, S., Turner, J. (2017) 'DEVELOPMENT OF MURINE MODELS OF LOIASIS TO ASSESS MICROFILARICIDAL ACTIVITY OF PRE-CLINICAL CANDIDATE ANTI-FILARIAL DRUGS.' In 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH). 95. Atlanta, GA, 13/11/2016 - 16/11/2016. AMER SOC TROP MED & HYGIENE, pp. 600-601.