Research theme: Neuroscience
Our research seeks to identify and characterise the brain changes that lead to neurovascular disorders, and helps to deliver healthcare solutions for people living with neurological conditions.
About our research
About our research
Life expectancy around the world has increased dramatically in the last few decades. By 2050, 16% of the world’s population will be over 65 years old.
There is an urgent need to detect early mechanistic changes in the brain that lead to neurovascular disorders and the progressive loss of cognition associated with ageing and neurodegenerative diseases.
Our mission is to bring together neuroscientists with multidisciplinary expertise to:
- identify early structural and functional alterations in brain connectivity, characterise the mechanisms underlying these alterations and develop tools to deliver agents to the brain to delay/prevent neurological dysfunction
- work with healthcare professionals, across Greater Manchester and beyond, to translate discoveries from fundamental research to the delivery of healthcare treatments that improve the lives of people living with neurological conditions
Our expertise
We study fundamental mechanisms underlying a range of physiological processes.
These include synaptic function, cognition, neurovascular function, auditory processing, and control of breathing using a range of approaches including:
- using genetically modified models of disease including using human induced pluripotent stem cells (iPSCs) derived models as a tool for drug discovery
- behavioural analysis
- immunohistochemical staining
- electrophysiological recordings
- neuroimaging
- genome-wide association studies (GWAS) and epigenetic meta-data analysis
Our research areas
Key publications
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Key publications
- Craig, CE, Jenkinson, NJ, Britain, JS, Grothe, MJ, Rochester, L, Silverdale, M, Alho, ATDL, Alho, EJL, Holmes, PS and Ray, NJ (2020) Pedunculopontine Nucleus Microstructure Predicts Postural and Gait Symptoms in Parkinson’s Disease Mov Disord, 35(1), pp 199-1207
- Ray, NJ, Bradburn, S, Murgatroyd, C, Toseeb, U, Mir, P, Kountouriotis, GK, Teipel, SJ and Grothe, MJ (2018) In vivo cholinergic basal forebrain atrophy predicts cognitive decline in de novo. Parkinson’s disease Brain, 141, pp 165-176
- Privitera, L, Hogg, EL, Gaestel, M, Wall, MJ and Corrêa, SAL (2019) The MK2 cascade regulates mGluR-dependent synaptic plasticity and reversal learning. Neuropharmacology, 155, pp 121-30
- Slevin M, E, EG, Capitanescu, B, Sanfeliu C, Zeinolabediny, Y, AlBaradie, R, Olah, P, Guo, B et al (2020) Monomeric C-Reactive Protein Aggravates Secondary Degeneration after Intracerebral Haemorrhagic Stroke and May Function as a Sensor for Systemic Inflammation. J Clin Med, 22;9(9), pp 3053
- Wall, MJ, Collins, DR, Chery, SL, Allen, ZD, Pastuzyn, ED, George, AJ, Nikolova, VD, Moy, SS, Philpot, BD, Shepherd, JD, Mϋller, J, Ehlers, MD, Mabb, AM and Corrêa, SAL (2018) The temporal dynamics of Arc expression regulate cognitive flexibility Neuron, 98, pp 1-9
- Webb, SD and Orton, LD (2020) Microglial peri‐somatic abutments classify two novel types of GABAergic neuron in the inferior colliculus EJN
Contact
Contact us
You can contact individual members of the team through their staff profiles.
For general enquiries about the neuroscience theme, you can contact research lead Prof Sonia Correa-Muller.