Programme (Pathway) lead - NHS Higher Specialist Scientist Training Program - DClinSci (Neurophysiology specialism).
Programme (Pathway) lead - NHS Scientist Training Program - MSc Clinical Science (Neurophysiology specialism).
Unit lead - NHS Scientist Training Program - Research project (all specialisms).
Unit lead - Human Neuroscience Unit (2nd year undergraduate).
Unit lead - School of Healthcare Sciences - Final year research project.
The brain is the centre of all we are. Every moment we experience in life is predicated on our own, unique mind. How the brain works, both in health and disease, is therefore of fundamental importance. I use my passion for this subject to teach a range of topics in neuroscience, from foundation (level 4) to post-graduate level (level 8), on a range of courses in the School of Healthcare Science, including: BSc (hons) Human Biology, Physiology (Physical Activity and Health), Sport Science and Human Biology, Sport Science and Physiology.
If you learn with me, you will investigate what brains are made of (neuroanatomy), how brains function (neurophysiology), what techniques can we use to study the brain, such as electrophysiology (EEG, ECog, evoked potentials, single unit recording, patch clamping), imaging (fMRI, CT, MEG, PET), genetics & epigenetics (sequencing, cloning, screens, gene therapy, CRISPR) and molecular biology (ELISA, Immunohistochemistry, in situ hybridisation, Western Blot, PCR). These aspects provide a fundamental basis that you will use to learn how the brain goes wrong in diseases such as dementia, epilepsy, schizophrenia, Parkinson's and stroke. From this, you will study what healthcare treatment options are available today, and what current research may lead to new treatments in the future.
PhD - Rocco Iemma, 2016-
MSc (by research) - Samuel Webb, 2016-
MBiomedSci - Zeenath Hussain, 2016.
MBiomedSci - Charlotte Cooke, 2016.
Nuffield Foundation Research Placements CREST gold award judge.
I graduated from UMIST with a BSc in Neuroscience where I learnt the joy of recording single units in the laboratory of Dr. Rasmus Petersen. I followed this with a PhD at Newcastle University, supervised by Adrian Rees, investigating the role of the commissure of the inferior colliculi in auditory processing. Following my PhD, I stayed on for two years in Prof. Rees' lab as a post-doc on a BBSRC funded project to extend my doctoral work. I took up my lectureship at MMU in October 2014.
My current research has three strands:
1) Fundamental aspects of anatomy and physiology of the auditory pathway.
2) Neural changes following hearing loss and their relationship to the development of dementia.
3) Neuromusculoskeletal features of dystonia.
Prof. Adrian Rees (Newcastle University) - commissural influences on auditory processing in the inferior colliculi.
Prof. David Furness (Keele University) & Dr. Fiona LeBeau (Newcastle University) - alpha-synuclein in presbycusis.
C. Eversfield, L. Orton (2018). Auditory and visual hallucination prevalence in Parkinson’s disease and dementia with Lewy bodies: a systematic review and meta-analysis. Psychological Medicine.
LD. Orton, CA. Papasavvas, A. Rees (2016). Commissural gain control enhances the midbrain representation of sound location. Journal of Neuroscience. 36(16), pp.4470-4481.
LD. Orton, A. Rees (2014). Intercollicular commissural connections refine the representation of sound frequency and level in the auditory midbrain. eLife. 3,
LD. Orton, PWF. Poon, A. Rees (2012). Deactivation of the inferior colliculus by cooling demonstrates intercollicular modulation of neuronal activity. Frontiers in Neural Circuits. 6,
MMU Healthcare Science Research Centre - Support of Excellence Awards
Action on Hearing Loss - Flexi Grant
MMU Research & Knowledge Exchange - Research Accelerator Grant
Wellcome Trust - Biomedical Vacation Scholarship
Speaker at "Living with Dystonia” meetings with The Dystonia Society.
British Neuroscience Association
British Society of Audiology